2CX0


Conserved Protein Domain Family
eIF2D_N
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cd11610: eIF2D_N 
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N-terminal domain of eIF2D and related proteins
This N-terminal domain of eIF2D co-occurs with a PUA domain. eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.
Links
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Statistics
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PSSM-Id: 211423
Aligned: 42 rows
Threshold Bit Score: 58.823
Created: 22-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PUA domain
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:PUA domain interface [polypeptide binding site]
Evidence:
  • Comment:Interactions with neighboring (C-terminal) PUA domain
  • Structure:2CX0: The N-terminal domain of Aeropyrum pernix touches the neighboring PUA domain, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                ##                                                 # #  
2CX0_A        10 LARLEARALSk-kERRSLLERLKPYY--------TRIPFSE-----KADLRLVKArtd-sgeYEIITVd-gVPCLFEWs- 72  Aeropyrum pernix
NP_495114      6 FTVKKNTNQRn-sDSRKLFNRLKEEVn-------GESNIDK-----KGQVAQVKLttfegtqMNVYTId-kVPMLFEFse 71  nematode
XP_637146     12 FTVSSQSVMRg-sDVKKLKQRVMDKYkgvt-seqIDLLINK-----KKDVGMVKLpn----kIQLISHq-nDPIFFEIn- 78  Dictyostelium d...
EFA81120       9 FQVGSQSLVRg-sDKKKLKEKLVQTYrpnvsieqLDQVIQN-----KRDLGLVKLqn---qpVQLYCQv-gDPLVFEYq- 77  Polysphondylium...
XP_003028568   7 LTLKASSAVRn-sDKRKLRQRIASTFacs--tedVDLLVPD-----NIQSTNFRShnn--apGVLYLDadgTPLWYSLgk 76  Schizophyllum c...
XP_003028569   7 GHLKTSSALRs-sDRRKLKQRVISTFgcs--aedGDVLVPEg----IQSIKFTTHmd---apGVAYLDaddTPLWFSLgk 76  Schizophyllum c...
ADY42968       1 MFRKSFVVKSntnMRNSDRRKLLSRLh-------FADRISS-----KAQVAHVRLlnsngvpLNVYTFd-kNPLLFEMed 67  pig roundworm
XP_001943143   6 FRIKSNAALKg-aDQKKLKSTICKCFnlt--nemLDEFLNHkqlslLKVITCTNDi------VKIYCAq-eVALVFDFk- 74  pea aphid
XP_003288177  12 LNISSQSIMRg-sDVKKLKQKLLDTYknis-teqLDVAVNK-----KKDVGFVKLpn----kIQIISQe-nNPIFFEFy- 78  Dictyostelium p...
EGN94711       7 GNLKTSAPLRs-sDRRKLKQRVVQSFsls--aeeGDVLVPDgl--lSVKFNTYSDd-----pGVAYLApggDPLWFTIgk 76  Serpula lacryma...

Feature 1           ####
2CX0_A        73 -dGRIYP 78  Aeropyrum pernix
NP_495114     72 -nGNIYP 77  nematode
XP_637146     79 --DTIYP 83  Dictyostelium discoideum AX4
EFA81120      78 --GVLYP 82  Polysphondylium pallidum PN500
XP_003028568  77 -sDELIP 82  Schizophyllum commune H4-8
XP_003028569  77 agDDLIP 83  Schizophyllum commune H4-8
ADY42968      68 -dPNLYP 73  pig roundworm
XP_001943143  75 --GKYYP 79  pea aphid
XP_003288177  79 --DKLYP 83  Dictyostelium purpureum
EGN94711      77 gsDDLIP 83  Serpula lacrymans var. lacrymans S7.3

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