Conserved Protein Domain Family
NTP-PPase_u2
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cd11539: NTP-PPase_u2 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea
The family corresponds to a group of uncharacterized hypothetical proteins from bacteria and archaea, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212146
Aligned: 33 rows
Threshold Bit Score: 60.7159
Created: 5-Dec-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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metal binding
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #  #                                                 
NP_456010           9 RTALYRLALQRFGp----dAQALKLTEEAAELAASAARnlngq-----------------------------------gs 49  Salmonella...
ABE95015           61 MRGVWERSIEHYGv----rDRMIVCMEECSELIHAVSKllrgr-----------------------------------gv 101 Bifidobact...
ZP_07456504         6 LQTIWRQSIDHYGk----qLQSIVCMEECAELIQAIIKklrkd----------------------------------tss 47  Bifidobact...
ZP_06113931        21 RRRIIRRSVESQPw----kLKCTIAMEEFAELTQAISKqirgy-----------------------------------dn 61  Clostridiu...
YP_001254195        6 QIEQCRRIVKCNGv----tLQKFVAIEELAELQQAISKyqrept---------------------------------ifg 48  Clostridiu...
YP_004519816       11 IDRVCRSVLERNSl----dDQIIVLIEEMGDLISNLCRyklegkln----------------------------anepgl 58  Methanobac...
ZP_08687743         4 YNPNINLILNSQSv----dVNKTIVIEELSELQKELCKdlrgy-----------------------------------er 44  Fusobacter...
CBK95063           60 LRTGTMPVDDNPVkl---tYNKVICIEELTELAAAIINyesycsesdadade----------------tvrehheklink 120 Eubacteriu...
ZP_03293492         8 LNKHDAIIDETKGyd---nTIQNILFEELGELIQAISKmnrskihlknlgikraletqkvkrenitpkienvkklinekf 84  Clostridiu...
REF_jgi:Plav_1339   8 QSTIAGWGEETFGpvsnpvALARRASIEMDELIEALEKgd---------------------------------------- 47  Parvibacul...

Feature 1                   #  #                                  
NP_456010          50 esDLAAELADVEIMTEQLRLQGmdrlid--fhkqkKLERLAARL 91  Salmonella enterica subsp. enterica serovar Ty...
ABE95015          102 reNLVEEMADVTICFNLLAIIHdvnpeqldkviraKTIREARQR 145 Bifidobacterium breve UCC2003
ZP_07456504        48 ndVLSEEMADVIVCLHQLKMMYgitdkaisdwveaKTLRLAKRM 91  Bifidobacterium dentium ATCC 27679
ZP_06113931        62 riGLLEEMADAYICLEFLKSIFnitpeelqkamdvKLQRERNKQ 105 Clostridium hathewayi DSM 13479
YP_001254195       49 idNIEEEIADVHIVLEELKIIFgidkeeienridyKLDRELKRI 92  Clostridium botulinum A str. ATCC 3502
YP_004519816       59 dvSIMEEMAKVKIRIRQLELTFecekdv-kkamedKAKEIGEGM 101 Methanobacterium sp. SWAN-1
ZP_08687743        45 rlEIKEEICDVYICLQLLKEIYnfsdedlekmykrKMMRNLERI 88  Fusobacterium mortiferum ATCC 9817
CBK95063          121 kyALLEEFTDVMICLHLMKKAYgftddmiskavriKLDNFKKKK 164 Eubacterium rectale M104/1
ZP_03293492        85 epNLAEEMADVIICLCWIAKIYevkedkivywlnkKCERMDRRI 128 Clostridium hiranonis DSM 13275
REF_jgi:Plav_1339  48 teEAARETADVLILLNRLGTTLgfdlle-avdakmKVNRARHWV 90  Parvibaculum lavamentivorans DS-1

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