Conserved Protein Domain Family
SLC6sbd_ATB0

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cd11501: SLC6sbd_ATB0 
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain
ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Statistics
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PSSM-Id: 271391
Aligned: 8 rows
Threshold Bit Score: 1009.41
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_009162     36 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRiLPLFQ 115 human
XP_001104391  36 RGNWSKKSDYLLSMVGYAVGLGNVWRFSHLTYNNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRiLPLFQ 115 Rhesus monkey
AAI55484      42 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGGAFLIPYTIMLALAGLPLFFLECSMGQFSSSGPVLVWRaVPILQ 121 western clawed ...
XP_003641183  37 RGNWSNKADYLLSMVGYAVGLGNVWRFPYLTYQNGGGAFLIPYTLMLALAGLPLFFMECSLGQFASLGPISIWRiLPLFQ 116 chicken
XP_003208366  61 RGNWSNKADYLLSMVGYAVGLGNVWRFPYLTYQNGGGAFLIPYTLMLALAGLPLFFMECSLGQFASLGPISIWRiLPLFQ 140 turkey
XP_001923596  42 RGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLAVSGLPLFFMESSFGQFCSQGPINVWKaVPILQ 121 zebrafish
AAI17617      53 RGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLAVSGLPLFFMESSFGQFCSQGPINVWKaVPILQ 132 zebrafish
XP_002763232  36 RGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYNNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRiLPLFQ 115 white-tufted-ea...
Feature 1                                               #                                        
NP_009162    116 GVGITMVLISIFVTIYYNVIIAYSLYYMFASFQseLPWKNCsswsdkNCSRSpivthCNVSTvnkgiqeiiqmnkswvdi 195 human
XP_001104391 116 GVGITMVLISIFVTIYYNVIIAYSLYYMFASFQseLPWKNCsswsdkNCSRSpivthCNVSTvnkgireivqmnkswvdi 195 Rhesus monkey
AAI55484     122 GVGITMVLVTTFVSIYYNIIIAYSLYYMFASFQtiLPWSDCfewadeMCSKVtr-gfCNVSLsnntvay----nltwvke 196 western clawed ...
XP_003641183 117 GVGVTMVIISTFVAIYYNVIIAYALYYLFASFQkvLPWSDCfswadeFCSKTrlvndCSAVLdgqiiha----nysfias 192 chicken
XP_003208366 141 GVGITMVIISTFVAIYYNVIIAYALYYLFASFQkvLPWSDCfswadeFCSKTrlvkdCNATLdgeiiha----nysfits 216 turkey
XP_001923596 122 GVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQdpLPWSIK------NCNTTa----SNISTa----------------a 175 zebrafish
AAI17617     133 GVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQdpLPWSIK------NCNTTa----SNISTa----------------a 186 zebrafish
XP_002763232 116 GVGITMVLISIFVTIYYNVIIAYSLYYMFASFQseLPWKNCsswsdkNCSRSpivthCNVSTinngiqeiiqinkswvdi 195 white-tufted-ea...
Feature 1                                                                                        
NP_009162    196 NNFTCINGseiyqpgQLPSEQYWNKVALQRSsGMNETGvIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVV 275 human
XP_001104391 196 NNFICINGseiyqpgQLPSEQYWNKVALQRSsGMNETGvIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVV 275 Rhesus monkey
AAI55484     197 RNLTCIENsivmedvDLPSKQYWEKVTLRLSgGLDETGeIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTAIFPYIV 276 western clawed ...
XP_003641183 193 NNLTCLNDtinykpvQFPSEQYWNKVALQRSsGLDETGnIVWYLALCLLLSWMIVGAALFKGIKSSGKVVYFTALFPYVI 272 chicken
XP_003208366 217 NNLTCINDtinykpvQFPSEQYWNKVALQRSpGLDETGnIVWYLALCLLLSWMIVGAALFKGIKSSGKVVYFTALFPYVI 296 turkey
XP_001923596 176 VNVSCGQIs-----gQSLSEKYWDEVALQRSsSMDETGpVVWHLALCLLLSWILVGAALFKGIKSSGKVVYFTATFPYIV 250 zebrafish
AAI17617     187 VNVSCGQIs-----gQSLSEKYWDEVALQRSsSMDETGpVVWHLALCLLLSWILVGAALFKGIKSSGKVVYFTATFPYIV 261 zebrafish
XP_002763232 196 NNFTCINGseiyqpgQLPSEQYWNKVALQRSsGMDETGvIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVV 275 white-tufted-ea...
Feature 1                                                                                        
NP_009162    276 LLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNC 355 human
XP_001104391 276 LLILLVRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNC 355 Rhesus monkey
AAI55484     277 LIILLVRGATLEGAFNGIDYYIGTKSNITKLMEAEVWKDAATQIFFSLSTAWGGLIALSSYNKFHNNCYSDAIVVCVTNC 356 western clawed ...
XP_003641183 273 LLILLVRGATLEGALDGIEYYIGKQSNITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIFVCVTNC 352 chicken
XP_003208366 297 LLILLVRGATLEGALDGIEYYIGKQSNITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIFVCVTNC 376 turkey
XP_001923596 251 LLILLIRGATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSIVVCVTNC 330 zebrafish
AAI17617     262 LLILLIRGATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSIVVCVTNC 341 zebrafish
XP_002763232 276 LLILLVRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNC 355 white-tufted-ea...
Feature 1                                                                                        
NP_009162    356 LTSVFAGFAIFSILGHMAHIsgKEVSQVVKSGFDLAFIAYPEALAQLPgGPFWSILFFFMLLTLGLDSQFASIETITTTI 435 human
XP_001104391 356 LTSVFAGFAIFSILGHMAHIsgKEVSQVVKSGFDLAFIAYPEALAQLPgGPFWSILFFFMLLTLGLDSQFASIETITTTI 435 Rhesus monkey
AAI55484     357 LTSVFAGFAIFSILGHMAFVtdKPVPEVVDSGFGLAFIAYPEALAKLPiSPLWSFLFFFMLLTLGLDSQFAMIETIITSI 436 western clawed ...
XP_003641183 353 LTSVFAGFAIFSVLGHMAFVlkRPVSEVVDSGFDLAFVAYPEALSKLPvSPLWSFLFFFMLLLLGLDSQFATIETLTTTI 432 chicken
XP_003208366 377 LTSVFAGFAIFSVLGHMAFVlkRPVSEVVDSGFDLAFVAYPEALSKLPvSPLWSFLFFFMLLLLGLDSQFATIETLTTTI 456 turkey
XP_001923596 331 GTSIFAGFAIFSVLGHMAHVyqRPVSEVADAGFALAFIAYPDALSKLPiSPLWSILFFFMLITLGLDSQFAGIEVISTCL 410 zebrafish
AAI17617     342 GTSIFAGFAIFSVLGHMAHVyqRPVSEVADAGFALAFIAYPDALSKLPiSPLWSILFFFMLITLGLDSQFAGIEVISTCL 421 zebrafish
XP_002763232 356 LTSVFAGFAIFSILGHMAHIsgKEVSQVVKSGFDLAFIAYPEALAQLPgGPFWSILFFFMLLTLGLDSQFASIETITTTI 435 white-tufted-ea...
Feature 1                                                                                        
NP_009162    436 QDLFPKVMKkMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIG 515 human
XP_001104391 436 QDLFPKVMKkMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILEIVGIIWIYGGNRFIEDIEMMIG 515 Rhesus monkey
AAI55484     437 QDAFPQMMKrMRIPVTVGCCVILFLLGLLCVTQSGIYWVNLIDYFCGGWAILFSAVLELVGINWIYGGNRFIKDIEMMIG 516 western clawed ...
XP_003641183 433 QDIYPKMMKkLRIPITLGVCVLLFFLGLICVTQAGIYWVNLIDHFCAGWGILFAAVLEIIGIVYIYGGNRFIEDIEMMIG 512 chicken
XP_003208366 457 QDIYPKMMKkLRIPITLGVCVLLFFLGLICVTQAGIYWVNLIDHFCAGWGILFAAVLEIIGIVYIYGGNRFIEDIEMMIG 536 turkey
XP_001923596 411 LDAYPEVLKsKRGLVTTAVCIILFLLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIG 490 zebrafish
AAI17617     422 LDAYPEVLKsKRGLVTTAVCIILFLLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIG 501 zebrafish
XP_002763232 436 QDLFPKVMKkMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDIEMMIG 515 white-tufted-ea...
Feature 1                                                                                        
NP_009162    516 AKrwIFWLWWRACWFVITPILLIAIFIWSLVQFHRPnYGAIPYPDWGVALGWCMIVFCIIWIPImAIIKIIQAKGNIFQR 595 human
XP_001104391 516 AKrwIFWLWWRACWFVITPILLIAIFIWSLVRFHRPnYGTIPYPDWGVALGWCMIIFCIIWIPImAIIKIIQAKGNIFQR 595 Rhesus monkey
AAI55484     517 EKhwTFWIWWRACWFVVSPLLLTAILLWSLITFHSPtYGSVVYPTWGTAIGWCMICFCLIWIPIvAVLKIIRAKGNVLQT 596 western clawed ...
XP_003641183 513 KKscFFWMWWRMCWFFITPVLLVAILVWSLVTFSAPtYGSVLYPTWGTAVGWCMIIFCVIWIPIvAVVKILKAEGNLFQR 592 chicken
XP_003208366 537 KKscFFWMWWRMCWFFITPVLLVAILVWSLVTFSAPtYGSVLYPTWGTAVGWCMIIFCVIWIPIvAVVKILKAEGNLFQR 616 turkey
XP_001923596 491 TKssLFWLWWRACWFFITPVVLSIILIWSLYTFTSPtYSSVAYPDWGISLGWCITAFSLMWIPIvAVWKVCKARGGLWQR 570 zebrafish
AAI17617     502 TKssLFWLWWRACWFFITPVVLSIILIWSLYTFTSPtYSSVAYPDWGISLGWCITAFSLMWIPIvAVWKVCKARGGLWQR 581 zebrafish
XP_002763232 516 AKrwIFWLWWRACWFVITPILLIAIFIWSLVQFHRPdYGTIPYPDWGVALGWCMIIFCIIWIPImAIIKIIQAKGNIFQR 595 white-tufted-ea...
Feature 1                                                      
NP_009162    596 liscCRPASNWGPYLEQHRGERYKDMVdpkkeadheIPTVSGSRKP 641 human
XP_001104391 596 liscCRPASNWGPYLEQHRGERYKGMVdpkteadyeIPTVSGSGKP 641 Rhesus monkey
AAI55484     597 ----CKAAQNWGPALSQHRGERYKHMLdskqahaeeLPTVSKLTGY 638 western clawed frog
XP_003641183 593 iascCRPTANWGPYLECHRGERYSHVVtpkkekeheIPTVSGFTYF 638 chicken
XP_003208366 617 iascCRPTANWGPYLECHRGERYSHVVtpkkekeheIPTVSGFTYF 662 turkey
XP_001923596 571 iksaCSPTEDWGPYLECHRGERYGTRGetd----pnIFVISNKVST 612 zebrafish
AAI17617     582 iksaCSPTEDWGPYLECHRGERYGTRGetd----pnIFVISNKVST 623 zebrafish
XP_002763232 596 lvscCRPASNWGPYLEQHRGERYKGMTdpkkevdheIPTVSGSRKP 641 white-tufted-ear marmoset

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