Conserved Protein Domain Family
O-FucT_plant

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cd11299: O-FucT_plant 
GDP-fucose protein O-fucosyltransferase, plant specific subfamily.
Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Statistics
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PSSM-Id: 211385
Aligned: 44 rows
Threshold Bit Score: 320.666
Created: 26-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
GDP-Fucose
Feature 1:GDP-Fucose binding site [chemical binding site]
Evidence:
  • Comment:by similarity to other members of this family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ####                                                                    
NP_566791    161 YVFIHAeGGLNQQRIAICNAVAVAKIMNATLILPVLk----QDQIWKDTTKFeDIFDVDHFIDYLKDDVRIVRDIPdwft 236 thale cress
BAK06813      87 FVTLSLtIGPEYHTSQIADAVVIARYLGATLVLPEI-----RGSELGKSRKFqEMYDVEKFKKNLDGVVKIVDKLPaewt 161 domesticated ba...
ABR18129      90 FIGVRLsNGPHYHRVQIADAVVVSKYLGATLLIPTI-----KDGHKEPNGQFdKIYDTSKFIASLQNIVRVVGRIPddms 164 Sitka spruce
ABR16242      95 FVQFRLsNGPHYHVSQVADAIVVAKYLGATLVLPEI-----KGSSADENSKFeEIYDADKFINSLRDVVKVARQLPndki 169 Sitka spruce
XP_001783770  53 YIIIECsGGLNQMRRDLCNGIGIARLLNATIVLPRFe----TSPYWNDTSGFgDIFDADFFLESVHSWVDVLRELPtnls 128 Physcomitrella ...
NP_566677     93 YVTFSLtNGPEYHISQITDAVMVAKHLGATLVLPDI-----RGSKPGDERNFeDIYDADKLIKSLENVVKVVKKLPeevs 167 thale cress
Q9SRV8        74 FIYAKIfGGFDKIRSSICDLVTISRLLNATLVIPELqeslrSKGISNKFKSFsYLYDEEQFIAFLKNDVIVMKTLPeslk 153 thale cress
XP_002972444   2 FLHAEIrGDFHEIRSSICDLIVVARLLNVTLVVPKLre-vvAKQISSKFRGFdYLYDEQHFVSVLSNDVPVVTRLPkrlr 80  Selaginella moe...
XP_001769408   3 FLFATIiGELHEIHSAVCDFVLIARLLNATIVLPKIqsipaVKGGNSKVKSFgYLYDEQHFITAVKDDVRVVKLLPnsfr 82  Physcomitrella ...
CAN79033      91 FITFSFsNGPEYHVSQLADAVVIARYLGATLVLPDI-----RKSERGQKRKFeEIYDAKKCVKNLGSVVRVALDQPsqas 165 wine grape
Feature 1                                                                                        
NP_566791    237 dkaelfssirrtvknipkyAAAQFYIDNVLPRIKEKKi-MALKPFVDRLGydn---vpqEINRLRCRVNYHALKFLPEIE 312 thale cress
BAK06813     162 tkkp-------avirvpnrVTEDFILDTIQPAFQKNSy-LRLAIIFSSVSlkpkgtnnkDLDSTACHAMFAGLKLKPEYS 233 domesticated ba...
ABR18129     165 sisp-------tvisvpyrVTHDYIDEHIRPVFNQKTv-IILDSFFPNINlkakegeniELEALRCLVMYKAVQFHSQLL 236 Sitka spruce
ABR16242     170 arrt-------vlvkiphrVTEEYIEENVEPIFRRKRs-IMLSIFFQSIDmkikegsnpGIESVRCFGMYGVLEFHPDIR 241 Sitka spruce
XP_001783770 129 mrqp-------vainchkvASPFDYVESLLPKLLQHTv-IVLRPSASQRSdry----pdSAKRARCHACFRSLRLVRRLQ 196 Physcomitrella ...
NP_566677    168 lrnm-------aivkvptrVTEDYIKEHIDPIFKSKGn-IRVASYFPSVNlrks-sqdgETDPVACLAMFGSLELQPEVN 238 thale cress
Q9SRV8       154 aarkrn---efplfkpknsASPKFYLEDVLPKLKKANviGLIVSDGGCLQsalp-asmpELQRLRCRVAFHALQLRPEIQ 229 thale cress
XP_002972444  81 qktkn-----qsylvvsstASVDFYVQDVLPEIEKEGvvGLSVSGGGCLQsllg-tdleHYQRLRCRVAFHALKFRQEIE 154 Selaginella moe...
XP_001769408  83 traslq---klpvktptrfSSVQFYLDEVLPALSAHGacGLVFAKGGGLQeilp-telvEYQRLRCRVAFHALRFREEIR 158 Physcomitrella ...
CAN79033     166 tgkl-------tvvrvpnrVSEEYIAAKIEPVFRTKGn-LSLSTYFPSLDmrra-eetkYLDSFACLAMFGTLQLQPELQ 236 wine grape
Feature 1                                # #                                                     
NP_566791    313 QMADSLVSRMRnrt-gnpNPYMALHLRFEKGMVGLSFCdfvgtreekvkmaeyrqkewprrfkngshlwqlalqkrkeGR 391 thale cress
BAK06813     234 EVAEQMVGKLKelseksdGRVLAVDMRTDLLEKKTCKTsgg-----------------------------------arRK 278 domesticated ba...
ABR18129     237 KLGGRIVNRMReagemseGRFIAVDLRVDLLQRKGCTNstseh-------------------------------dkskTK 285 Sitka spruce
ABR16242     242 RVGDKMLKKLHdagdgslRHFVAIDLRMDILLEKGCENaggs--------------------------------irsgTK 289 Sitka spruce
XP_001783770 197 ETADTLLERLP-------HPFVVLHLRFEPDMIAYSRCrynlssasmasinrvrg-------frqvfgvadekswrkkGK 262 Physcomitrella ...
NP_566677    239 AVAESMVERLRthsrksgGRFIAVDLRIDILEKKNCHTtgv-----------------------------------vgSK 283 thale cress
Q9SRV8       230 VLAKEMVDRLRks----gQPFLAYHPGLVREKLAYHGCaelfqdihseliqyrraqmi-kqrfileelivdsrlrrdnGL 304 thale cress
XP_002972444 155 ELSTKMLARLKta----gKPFMALHLGLERDTLAYHGCaerfqdvhteliqyrrakmi-kngivrgelnvdsemqwlnGS 229 Selaginella moe...
XP_001769408 159 GLGAQLVRRLEah----gRPYVVVHFGLERDVLAYHGCaelfqdlqtesiqyqrkkml-isaeidgelridshkqrhrGL 233 Physcomitrella ...
CAN79033     237 EVVDSMVGRLRnxsrksnGQFVAVDLRFXVLERECRRRea------------------------------------kgKK 280 wine grape
Feature 1                                 ###                                                    
NP_566791    392 CPLEPGEVAVILRAMGYpkeTQIYVASGQvygGQNRMAPLRNMFPNLVTKEDlagkeelt-------------------- 451 thale cress
BAK06813     279 GCYNPQEVLNFLKKVGFsanTTIYLTETW---WHKGLNNLKKAFPHTYTKDDimpaekkge------------------- 336 domesticated ba...
ABR18129     286 KCVTALEVGEFLKELGFptdTAIYLTQSR---WDATLDPLREIFPNVYTKEYsmpfneerq------------------- 343 Sitka spruce
ABR16242     290 KCFGAQDVGIFLRKVGFqtdTPLYLTQST---WHENLNSLKDIFPNVYTKENsmpsdekeq------------------- 347 Sitka spruce
XP_001783770 263 CPLTPQETAFILQALNIpasTPIYLAAGS---GLLELHKLASTYTQLFQKSDflhadrl--------------------- 318 Physcomitrella ...
NP_566677    284 TCYNAQEIALFLRKLGFasdTTIYLTQPR---WDSSLNILKDIFPKTFTKEAimpaskrsk------------------- 341 thale cress
Q9SRV8       305 CPLMPEEVGILLKALGYsqkAIIYLAGSEifgGQRVLIPLRAMFPNLVDRTSlcsteelselvgpetplpentykmpprk 384 thale cress
XP_002972444 230 CPLMPDEVGVLLRSLGYkqtSRIYISGVEvfgGQRILLPLRSMYPNLEDRTTlttarerftvygeepdfpppppfilpki 309 Selaginella moe...
XP_001769408 234 CPLMPSEVGLLLEAFGFrndTQLYMAGTEitgGQRVVLPLRSMYPSLDDRFTlttdqerfalyavdqqrtpdtsepgsvy 313 Physcomitrella ...
CAN79033     281 NCYNAEEIGVFLKKIGFdrdTAIYLTQSK---WHHSLDALREIFPKTFTKEGimpaekkak------------------- 338 wine grape
Feature 1                                                                      #                 
NP_566791    452 -----------------------------------------------------tfrkhvtsLAALDFLVCLKSDVFVMTh 478 thale cress
BAK06813     337 ----------------------------------------------------flnsgdsdlARALDLEVCSQSDVFVPAi 364 domesticated ba...
ABR18129     344 ----------------------------------------------------ilysgktqfEKALDFYICSQSDIFVPAi 371 Sitka spruce
ABR16242     348 ----------------------------------------------------lfhsgrtefERALDFFICSNSDVFVPAi 375 Sitka spruce
XP_001783770 319 ------------------------------------------------------kalkgsrRAAIDWYVSLHAYAYIATf 344 Physcomitrella ...
NP_566677    342 ----------------------------------------------------ylesvsseyENVIDFYISSRSDVFVPAi 369 thale cress
Q9SRV8       385 sdkqlkeewnkagprprplppppdrpiyqhekegwygwltendtepspspmdlrnqahrllWDALDFAVSVEADVFFPGf 464 thale cress
XP_002972444 310 nekarlaawekagprprplpppagrpkyshelegwwgwigesdtepapalkdmrirshkllWQALDYIICTQADAFFSAf 389 Selaginella moe...
XP_001769408 314 snawkklfvwgknr-----psgysypsqkgwwrsvgeceygtekyfastpvegetndiqllHAALDYIVSLDANTYFPAf 388 Physcomitrella ...
CAN79033     339 ----------------------------------------------------flssessefEKAIDFYICSESDVFVPSi 366 wine grape
Feature 1               ###                
NP_566791    479 ------gGNFAKLIIGARRYMGHRQK 498 thale cress
BAK06813     365 ------pGMFYGNVAGRRIASGLTQI 384 domesticated barley
ABR18129     372 ------sGMFYSTVAGQRISLGKTQI 391 Sitka spruce
ABR16242     376 ------sGMFYANVVGHRIAAGRTQI 395 Sitka spruce
XP_001783770 345 ------vGNMDKMVVSDRVLAGKHRN 364 Physcomitrella patens subsp. patens
NP_566677    370 ------sGLFYANTVGKRIALGKPQV 389 thale cress
Q9SRV8       465 nndgsgwPDFSSLVMGQRLYERPSSR 490 thale cress
XP_002972444 390 dedksghPNFASLVMGHRVYAGASRR 415 Selaginella moellendorffii
XP_001769408 389 dkdrqglPNMASLIMGHRLYQSASLK 414 Physcomitrella patens subsp. patens
CAN79033     367 ------sGLFYANVVGKRIASGKSQI 386 wine grape

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