3C4T,3C4B,5ZAK


Conserved Protein Domain Family
DSRM_DICER
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cd10843: DSRM_DICER 
double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins
Dicer (also known as helicase with RNase motif (HERNA), or helicase MOI) is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. Dicer contains a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380680
Aligned: 20 rows
Threshold Bit Score: 103.658
Created: 1-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative RNA
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Homo sapiens TARBP2 (5N8L) binds siRNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ## ##  ##  ##   #    # ## # #                ####  #            
3C4T_A        200 RSPVRELLEMEPETAKFSPAER-TYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLK 262  house mouse
BAI63215     1749 ISPVRELLEMEPETARFGPPEK-TIDGKTRVTVNVVGKGQFKGIGRNYHIAKATAARFALRHLK 1811 Hemicentrotus pulcherrimus
P34529       1832 RSPIRELMEFEQSKVRFSKMERiLESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLH 1895 Caenorhabditis elegans
XP_009860329 1992 RSPVRELLEMEPETAKFSCAEK-RYDGKVRVTVEIIGKGRFKGVGRSYRIAKSAAARRALRYLK 2054 vase tunicate
XP_013409876 1796 RSPVRELLELEPETAKFEKPER-TMEGKIRVTVNVVGKGSFRGLGRNYRIAKSTAARRALKYIR 1858 Lingula anatina
ELU12939     1570 KSPVRELLEMEPETAKFEKPER-TMDGKIRVTVNVVGKGNFRGIGRNYRIAKSAAAKRALKHIK 1632 Capitella sp. I Grassle & Gra...
XP_002610617 1694 RSPVRELLEMEPETAKFSPSER-TYDGKVRVTVTVIGKGQFKGVGRNYRIAKSAAARKALRALK 1756 Florida lancelet
PVD26191     2094 KSPVRELLEMEPETAKFEKPER-TLDGKIRVTVNVVGKGVFSGVGRNYRIAKSAAAKKALRFIR 2156 Pomacea canaliculata
ABQ02405     2558 KSPVRQLLELEPEGTKFERARR-MVDGRISVCAHVLGKGRFYGVGRNYRLAKSLAAKRALRVLR 2620 Schistosoma mansoni
XP_006824151 1798 ISPVRELLEMEPETARFGLPEK-TMDGKTRVTVTVAGKGTYRGIGRNYRIAKSAAARRALRALK 1860 Saccoglossus kowalevskii

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