Conserved Protein Domain Family
SAM_caskin1,2_repeat1
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cd09497: SAM_caskin1,2_repeat1 
SAM domain of caskin protein repeat 1
SAM (sterile alpha motif) domain repeat 1 of caskin1,2 proteins is a protein-protein interaction domain. Caskin has two tandem SAM domains. Caskin protein is known to interact with membrane-associated guanylate kinase CASK, and apparently may play a role in neural development, synaptic protein targeting, and regulation of gene expression.
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Statistics
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PSSM-Id: 188896
Aligned: 15 rows
Threshold Bit Score: 111.967
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAL49758      471 GKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPD 536  human
AAF58176      254 QRNDELIIDWLLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLD 319  fruit fly
XP_002403363   24 GRDTEVLTTWLKNLHFEEYVHLFLQAGYDMPTISRMTPEDLTAIGITKPAHRRKLKSEISNLNIPD 89   black-legged tick
EEZ99934      307 VPDQEIIHAWLVDLQYDEYFPLFVSAGYDLPTIGRMTPEDLTAIGIKKPNHRKRLKAEIAQLNLPD 372  red flour beetle
XP_795586     627 IKDADRIYEWLRRQRLMEYTNNFTRSGYDMPTIAKMTPEDLTAIGITKPSHRKRITAMIAQMREAD 692  purple urchin
XP_001688167  195 RTDHDVISEWLMEIHFHEYTYLFLEAGYDLPTIARMTPEDLTAIGIRKPNHRERLKRHIDALKLPD 260  Anopheles gambiae str. PEST
XP_002124798  571 NPADEEVFKWLRSFGLEQYTSNFIEHGYDLATISHTSPADLTAIQIAKPAHRKKLSTHVSQLRKDS 636  Ciona intestinalis
XP_001899150  157 MSEAEILALWLGDLGYPEYLTAFLTQGYDLSTIARITPEDLTALGITHPTHRRFLISEIHRWHITD 222  agent of lymphatic filariasis
NP_001024475  332 VPHAEVLANWLDSINMSNYLAVFLKQGYDLQTIARCTPADLLSLGIKNPDHRKKLMSDIHSWKIID 397  nematode
XP_002155293  709 NNAEKQVLDWLNELKLTYYYDHFITNGFDMTSIHAITPEDLNSLEIMKTGHRKKLLSEIARLPANN 774  green hydra
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