Conserved Protein Domain Family
PLDc_unchar6
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cd09176: PLDc_unchar6 
Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif
Putative catalytic domain of uncharacterized hypothetical proteins with similarity to phospholipase D (PLD, EC 3.1.4.4). PLD enzymes hydrolyze phospholipid phosphodiester bonds to yield phosphatidic acid and a free polar head group. They can also catalyze transphosphatidylation of phospholipids to acceptor alcohols. Members of this subfamily contain one or two copies of the HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) that characterizes the PLD superfamily.
Links
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Statistics
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PSSM-Id: 197273
Aligned: 63 rows
Threshold Bit Score: 62.7456
Created: 28-Jun-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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putative activecatalytic siteputative
Feature 1:putative active site [active site]
Evidence:
  • Comment:The HKD signature motif (expanded to H-x-K-x(4)-D-x(6)-G-S-x-N, where x represents any amino acid residue) characterizes the PLD superfamily.
  • Comment:Most residues in the HKD motif are part of the active site.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
YP_001960072 217 KGFDWKPPm-aNRLAVISPFCs--dEALRVLAKNt-------kVADALISRpes----msaLKKETLDLFTQclhlddaa 282 Chlorobium phae...
ZP_04601417   12 YYLEELIKqakERLWLISPYLkf-sDRIKELLEDknr---mkiDIRIVYGKs--------eLQPAEANWLKTldyvr--- 76  Kingella oralis...
YP_860957     12 YHLEELIKnttDRLILISPYLqf-hNRIKDHIHNlni---qkkDIRIVYREs--------kLQLEESNWLETqigvr--- 76  Gramella forset...
ZP_02162119   11 YEIEQILDksdDYLVLVSPYFkl-tQRLKVRLSDafk---svdNVFLLYREn--------eIKYQELNWLKSfsnvk--- 75  Kordia algicida...
YP_001733861  12 YHIEQIIIgakTNIILLSPYLflsrTLLERLQDAerr----niKIVVVYSQn--------kLRQAEIEVVRNfknld--- 76  Synechococcus s...
ZP_01252554   12 YWLNEIISgaeKELILIVPYIktsnNIFESLQDAder----gvEIILIYREn--------kLNEKEKIKLFSlknit--- 76  Psychroflexus t...
ZP_01201716   12 DAIDDVIIntkKFLFITSPYIkl-dDHFKERFDLikn----dpSIYLHILFgkneddfyksVNSDDLEYFKSfpnvs--- 83  Flavobacteria b...
ZP_01877353   12 FHFHRLMTqaqKKLILVTPVLkf-nKKFKQLLEIknn---saaKIKVIYGIs--------rLSNDEMKFLKNlefvh--- 76  Lentisphaera ar...
YP_629051     24 RRLHGLIDeaqKHVTLISPYVs--iEKLRDIERKirqalerevAVTLVIREgdestrgpsqQGVELLVSLMQagmrl--- 98  Myxococcus xant...
YP_001195369  12 LHHVKQIFqgaKNVFIISPYItk-nIALLDFAEFns-----leKVTVVTTLkpf-----dkDQYSKINYFKElynifnsr 80  Flavobacterium ...

Feature 1                           # #                  # #            #     
YP_001960072 283 etedgeeddateqplatGLHAKVYLLEtryysdytHVIMGSANATnaalnaSKNIEILVGL 343 Chlorobium phaeobacteroides BS1
ZP_04601417   77 ------------tsycaNLHAKCYISEg-------ACIITSLNLYef--sqINNNEMGILL 116 Kingella oralis ATCC 51147
YP_860957     77 ------------tsvcsTLHAKCYLNEs-------EAIVTSMNLYsf--sqQNNDEMGIYV 116 Gramella forsetii KT0803
ZP_02162119   76 ------------ifaikNLHAKIYLNQe-------YALISSMNLYey--sqINNHEVAVMI 115 Kordia algicida OT-1
YP_001733861  77 ------------ilyspNLHAKCYFNEq-------EMIITSMNMYef--seKNNREMGILI 116 Synechococcus sp. PCC 7002
ZP_01252554   77 ------------ilhhpNIHCKCYYNGa-------QLILCSMNLYey--seLNNREMGTLF 116 Psychroflexus torquis ATCC 700755
ZP_01201716   84 ------------iiyepRLHAKSYVNEs-------QGIITSMNLYdy--saENNVEYGVGF 123 Flavobacteria bacterium BBFL7
ZP_01877353   77 ------------nsvcnDLHASIFLNEh-------KCIIGGLNLHef--ytPEKGALGVLL 116 Lentisphaera araneosa HTCC2155
YP_629051     99 -------------fvvrDLHAKLYYSEr-------HALITSLNLIes--sfNNSIEVGICI 137 Myxococcus xanthus DK 1622
YP_001195369  81 n-------iefeilidnFLHGKIFIGEntd--gsaKAIITSANFTdr--glRINNEWGILI 130 Flavobacterium johnsoniae UW101

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