Conserved Protein Domain Family
RHO_alpha_C_CMO-like

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cd08883: RHO_alpha_C_CMO-like 
C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases
C-terminal catalytic domain of plant choline monooxygenase and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. Plant choline monooxygenase catalyzes the first step in a two-step oxidation of choline to the osmoprotectant glycine betaine. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.
Statistics
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PSSM-Id: 176892
View PSSM: cd08883
Aligned: 12 rows
Threshold Bit Score: 237.629
Threshold Setting Gi: 88711243
Created: 14-Apr-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ##  ## ##   #                                                
Q93XE1       266 INRSEFPMES--NWKVFCDNYLdSAYHVPYAHKYYaa-eLDFDTYKTDLl--------------EKVVIQRVASSsnkpn 328 Chinese spinach
ZP_01105331  183 SRSKDYQVNA--HWALYCDNFL-EGFHIPFVHDDLna-vLDYGTYDTIIh--------------EHLNLQIGYAEgtdai 244 Flavobacteriale...
YP_001250966 182 ERCKDYVVKS--HWALYCENYL-EALHIPFVHPSLrk-vIDCNTYTTELf--------------RYCNLQLALANpeeas 243 Legionella pneu...
YP_001275338 179 YKRVDYEIAC--NWKVYVDNYL-EGYHIPVAHPGLfk-eIDYKQYRVETf--------------RYYSKQHAPIRenpds 240 Roseiflexus sp....
YP_001411439 169 QLAREFTIEAdvNWKTYGDNYA-EAWHIPTIHPGLna-aIDMASYKIAT---------------VGHTLQSHMADardg- 230 Parvibaculum la...
YP_823823    185 AYRRDYVIEC--NWKVYVDNYL-EGYHLPAAHPSLfr-eLDYAGYRVETf--------------AQYSSQIAPIRaaasg 246 Solibacter usit...
T08550       235 ICRREYTIDC--NWKVFCDNYLdGGYHVPYAHKGLms-gLDLETYSTTLvascdelyglryqifEKVSIQECGGGskvge 311 thale cress
XP_001752587 235 VATREYVIKC--NWKVYCDNYLdGGYHVPHAHSSLaa-cLDLPSYSTSLl--------------ERVSIQSCGAAkesgl 297 Physcomitrella ...
YP_755380    186 HHSRIYDVAC--NWKVYVDNYL-EGYHLPFVHPDLtq-vVSYPDYTTELg--------------RYWSLQRSPVDaetea 247 Maricaulis mari...
ACO70191     186 VARREYRLRC--NWKVFADNYLdGGYHVPFAHPALvtdgVDMRKYETEVy-------------gEYVSVQTHGAPaaelt 250 Micromonas sp. ...
YP_002129797 163 TERRTHHIAC--NWKTYVENYL-EGYHLPMVHPEFde-dIVVADYRVEIe--------------GEIVFHAAPARdgs-- 222 Phenylobacteriu...
ZP_02735543  187 HARRSYDLRC--NWKVYVDNYLdGGYHVNTVHPALag-tLDYTNYRTTCd--------------GNAVLQSSPTKpaegd 249 Gemmata obscuri...
Feature 1                      ## #       # #      # #                              #  #      ## 
Q93XE1       329 g-------fdrlgsEAFYAFIYPNFAVERYGPWMTTMHIGPLGPRKCKLVVDYYLENam--mnDKPYIEKSiminDNVQ- 398 Chinese spinach
ZP_01105331  245 fdlpeghvdygkkiAAYYYWVFPNMMFNFYPWGLSVNVVQPLGINRTKVSFYSYVYDs----sKLNVGAGSi--lDKVE- 317 Flavobacteriale...
YP_001250966 244 fdlpkgaqdygkqvAAYYFWIFPNTMLNFYPWGCSVNVVKPLSPELTQVSFLSFVLDe----sKLGKGAGGa--lDQVE- 316 Legionella pneu...
YP_001275338 241 lyrr--hleegapaQALYYWIFPNLMLNIYPDNLQINIILPLGHERTLTIFEWYVLDvdrpevAEEFHRSFkf-sDVVQ- 316 Roseiflexus sp....
YP_001411439 231 -----------gktDGFWVWRLPGLFFNMYNWGMNVAQLEPLGPRRMKLTYRYFVKDld--ptKQAERDALi---DWAYm 294 Parvibaculum la...
YP_823823    247 earr--yefgdnsnRALYYWIFPNIMLNVYPDNLSANFIVPLGPEKTLTIFEWFSYGea--gvAQQTIDFS----DEIQ- 317 Solibacter usit...
T08550       312 dg------fdrlgsEALYAFVYPNFMINRYGPWMDTNLVLPLGPRKCKVVFDYFLDPsl--kdDEAFIKRSleesDRVQ- 382 thale cress
XP_001752587 298 ---------vrvgnVATYAFVYPNFMINRYGPWMDTNLVIPISMSECRVIFDWFLEPsl--vhDKEFIDSSiadsEVVQ- 365 Physcomitrella ...
YP_755380    248 ----------yaagEALYFFIYPNTMLNILPGRMQTNRVVANGPDACRVEFDFYYADgea-grAEADDAFS----DSVQ- 311 Maricaulis mari...
ACO70191     251 ----------rlgdSALYAFVYPNLMINRYGPWMDVNVVLPTGPNECMVLFDYFIRAdat-gaTDAFVNESlrasDAVQ- 318 Micromonas sp. ...
YP_002129797 223 ------------vnAGLWAWMWPNLAINTYRHGYMVERMTATGPESTRLDYFYFFDPa-----RAAELAEMfvvsDRVT- 284 Phenylobacteriu...
ZP_02735543  250 a-------gqtrtgDAAYWWLYPNFMLNAYAGVMDTNLVLPLGPDRCRVVFDFYFADs----lDHDFRRKSvevaEQVQ- 317 Gemmata obscuri...
Feature 1            #                                         
Q93XE1       399 --KEDVVLCESVQRGLETPAYRsGRYVMPiEKGIHHFHCWLHQTLN 442 Chinese spinach
ZP_01105331  318 --MEDEEVVEGVQKGVRSQFYEaGRFSPTrEQGVHHFHRLLAQFLN 361 Flavobacteriales bacterium HTCC2170
YP_001250966 317 --QEDERVVESVQRGIKSRYYDmGRFSPTkEQGTHHFQRLLCEFLN 360 Legionella pneumophila str. Corby
YP_001275338 317 --KEDIEICEAVQKRLRSRSYNvGRFSVLrENGVHHFHGLLAEYLQ 360 Roseiflexus sp. RS-1
YP_001411439 295 vaKEDIDICIAVQRNLETGIYErGRLSSVhENGVIQFQEMVASAHR 340 Parvibaculum lavamentivorans DS-1
YP_823823    318 --QEDIRICESVQRGLRSRHYDrGRFSVKrENGVHHFHGLLAARLK 361 Solibacter usitatus Ellin6076
T08550       383 --MEDVMLCESVQRGLESQAYDkGRYALV-EKPMHHFHCLLHHNLK 425 thale cress
XP_001752587 366 --KEDIILCEDVQNGLSSPAYDvGRYAPRvEQAMHHFHCLIYDDLS 409 Physcomitrella patens subsp. patens
YP_755380    312 --DEDRMICEHVQKGLASGAYRpGRLSPDqEAGVWHWHNLLRDAYA 355 Maricaulis maris MCS10
ACO70191     319 --SEDKWLCEKVQGGLESPGYGtGRYAPAmEAAMYHFHRRLWRDLT 362 Micromonas sp. RCC299
YP_002129797 285 --AQDKEICEMVQRNLAAGVYRpGVLSPKhEAGIAWFQSKVAGRHD 328 Phenylobacterium zucineum HLK1
ZP_02735543  318 --QEDIGVCEEVQRNLHSRSFStGRFSVKrENGGHHFHAKLGRVLR 361 Gemmata obscuriglobus UQM 2246

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