Conserved Protein Domain Family
SRPBCC_11

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cd08866: SRPBCC_11 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176875
View PSSM: cd08866
Aligned: 29 rows
Threshold Bit Score: 157.007
Threshold Setting Gi: 158335035
Created: 3-Jun-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #        ### ##              #      # # # #             # #             # # 
YP_912370     46 VCGKIFIAAPPEAIWKTLTDYNNLSETLPKVLSSKLVGqHGNTIILDQtGRTGIFF--FEKTVSFQLKLeeeylnRVSFE 123 Chlorobium phae...
NP_661952     67 VVGKVYIEASPKHVWAAITDYNNHKSFVPKLIDSGLISdNGREQVMFErGKTGIFL--FRKTVYIKLSLqgeypkRLDFH 144 Chlorobium tepi...
YP_375823     68 VTGRIRVQAAADQVWDVITDYDHHWQFLPNVKESGLLSdNGREQEMFQtGRTGVLL--FRKTVHIQLRLkgerprRLVFR 145 Pelodictyon lut...
ZP_01386273   77 VRGDVYIAAPPETVWAVITDYNNHKNFVPGVLDSGIISdTGSEKVMFEkGKSGLFV--FSKTVNVKMRVwgekpkRLNFE 154 Chlorobium ferr...
YP_001100936  68 VSVRTTVKAPLALIWNTLTDYDHLAQFIPGMKKSRLIErQGRVAVIEQsGYAHVWFfhFPIDVTVEVTEhp--ssAIRVR 145 Herminiimonas a...
YP_001516207  41 YVAQVVMESEPETAWQVLTDFEHLAQFLPNVVATQILEaSAQRTVVEQtNVSQILFaqVQSKVRTENRVma--pgKLSFH 118 Acaryochloris m...
YP_001959222  60 VSGSIYVHSKPATIWNIITDYNNLANTMPRVRESRVVEdKGNIKIIDQtSKTGVLF--IKIKFSTRMTItenfpeTLSFE 137 Chlorobium phae...
YP_001998339  47 MKSTVYINALPVTVWKVLTDYNNLKRYIPRMTESDLVEeNGDLKVIALiGEFRVLF--FKKTIRLSINMhetypsRIDYE 124 Chlorobaculum p...
YP_002015380  35 AEGAIAVNAPAETIWNLLTDYNNLSTIIPKVIDSRLIEdNGSHKIIDQtGKSGILF--IEKSVRIVLKVtekfpnALLFE 112 Prosthecochlori...
ZP_03543002   40 VKASAIMQVRPATAWSVISDYEHLAEFVPGMQSSRVLQrNGNQVVVEQkGSLGFLF--FRQAIEIRLAVnewphqRIIAH 117 Comamonas testo...
Feature 1                    ## # #       # # # #          ##### ### ###  #      
YP_912370    124 QlsGDFSIYRGEWIISPMEeteGCVLVYHAEIKPAFFAPpiLVSFVQRQDLPGIFKAHKQRAES 187 Chlorobium phaeobacteroides DSM...
NP_661952    145 QieGDFKVYEGDWLIERASdgkGSILTFRAKIKPDFFAPamFVRKVQQNDLPMVLAAMKKRAES 208 Chlorobium tepidum TLS
YP_375823    146 QtrGDFKVYNGEWRISDDPlgrGVLLTFVAEIKPDFFAPamFVRKVQKKDLPGLLNAMKKRAEH 209 Pelodictyon luteolum DSM 273
ZP_01386273  155 QitGDFKVYHGEWLLLVSPpdkGTFLTYKAEVKPDFFAPgfAVRNVQKKECPLMLSAMKKRSES 218 Chlorobium ferrooxidans DSM 13031
YP_001100936 146 LlkGNLKRLEGHYEIEKIAd-gLYALRWSGTIEPGVAVPgfLATDLMRKNISEQFLGMVDEIER 208 Herminiimonas arsenicoxydans
YP_001516207 119 LlkGDLNYLQGYWQVLPLAt-sQVLVKQVVSADADLGFLegSFHLLFRETLKRTLAAIQTETQA 181 Acaryochloris marina MBIC11017
YP_001959222 138 LisGDFKTFNGKWVLTPDEsrnGTFLVWSAQVNPDFSAPdfIVDAVQKRDLRELLETIRELSES 201 Chlorobium phaeobacteroides BS1
YP_001998339 125 KisGDFEIYRGSWILQAYSs-kGTILTYKSEIKPSFVAPdfIFQGVLKKDMVAGLTALKAEAER 187 Chlorobaculum parvum NCIB 8327
YP_002015380 113 MveGDFSTYTGSWSFRPGSsreQTFVSWQTDFKPTFFAPpfLVSFLQHQDLPVVMKAIKALAES 176 Prosthecochloris aestuarii DSM 271
ZP_03543002  118 AvgGNLKQMDGSYTLETLAd-gRVRLSYSARLVPAFTIPplLGKAVVRQLLTRQFKALVDEILH 180 Comamonas testosteroni KF-1

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