2EP6


Conserved Protein Domain Family
C2C_MCTP_PRT

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cd08377: C2C_MCTP_PRT 
Click on image for an interactive view with Cn3D
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
MCTPs are involved in Ca2+ signaling at the membrane. The cds in this family contain multiple C2 domains as well as a C-terminal PRT domain. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.
Statistics
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PSSM-Id: 176023
View PSSM: cd08377
Aligned: 15 rows
Threshold Bit Score: 187.892
Threshold Setting Gi: 256073510
Created: 2-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #     #                                             # #     #   
2EP6_A        13 GILQVKVLKAADLLAADfsgkSDPFCLLELgnDRLQTHTVYknlNPEWNKVFTFPikdihdVLEVTVFDEDgdkPPDFLG 92   human
CAE30451      75 GFLQVKLIRATDLPSTDisgkSDPFCTLELgnSKLQTHTICktlNPEWRTALTFPirdihdVLVLTVYHEDgdkAPDFLG 154  zebrafish
NP_611372    518 GHLTVKVFGATGLAAADiggkSDPFCVLELgnARLQTQTEYktlTPNWNKIFTFNvkditqVLEITVFDEDrdhRVEFLG 597  fruit fly
XP_001637803 304 GWLQVKLHRAVGLASADlggaSDPFAVIEVnnQRLVTNTIYktlNPNWNKIYEMPvwdihdVLDITVFDEDkrgAPEFLG 383  starlet sea an...
XP_001900971  23 RTRMHTLFRARNLASVDamnkSNPFVVVELvnALLQTHTEYktvNPEWNKIFTFAvkdihsILEITIYDEDpnkKAEFLG 102  agent of lymph...
XP_002116376 396 GYLIMKVIRAKELPAADfggnSDPFVIAEVrnRRIQTPTVYktiNPEWGKVYQFGikdihdIVKISVYDEDk-aKKEFLG 474  Trichoplax adh...
NP_491908    531 SLFNCLVFGAEDLVAKDfggkSDPFAVLELvnTRVQTNTIYktlSPSWNKIYTFAvkdihtCLQVTIYDEDpnnRFEFLG 610  nematode
XP_002435249 181 GHLVVKVFKAQGLASADlggkSDPFCVLELvnSRLQTHTEYktlSPEWNKIFAFSsry-faICIQADGDTYrdkKCEFLG 259  black-legged tick
XP_002601991 570 GLLQVKVIKATGLLAADfggkSDPFCVLELtnARLQTQTIYktlNPEWGKVFTFQvkdihsILEVSVYDEDrnkSAEFLG 649  Florida lancelet
XP_001749528 504 GMLKVYIHMARGLAARDmggtSDPFVVCELgnSRQRTRTIQknvNPVWNDTLQFYvrdifdVLRVTIYDEDkgdKKEFIG 583  Monosiga brevi...
Feature 1                                               
2EP6_A        93 KVAIPllsirdgqPNCYVLknkdleqafKGVIYLEMDLI 131  human
CAE30451     155 KVAIPlltisngqQITRMLktnnlsranKGSITLELKVL 193  zebrafish
NP_611372    598 KLVIPllriksgvKRWYTLkdknlcvraKGNSPQIQLEL 636  fruit fly
XP_001637803 384 RVVIPllhitpceKRLYQLknkslegraKGHLILTLDVI 422  starlet sea anemone
XP_001900971 103 KIAIPllqiqnceRKWYALkdrklrtpvKGQILLEMDII 141  agent of lymphatic filariasis
XP_002116376 475 KCMIPlldvesgvRKWHNLkdrkfrdkaKGQIEIEMTVV 513  Trichoplax adhaerens
NP_491908    611 RVQIPlksirncqKRWYGLkdeklrkrvKGEVLLEMDVI 649  nematode
XP_002435249 260 KLAVPlikikngeKKWYGLkdrklktrvKGQILLEMNVV 298  black-legged tick
XP_002601991 650 KVAIPllrikngeRKAFFLkdkklrrrtKGSIVLEMEVI 688  Florida lancelet
XP_001749528 584 ALIIPlleirngvRDYWPLktasltgraKGKIQLSMDLQ 622  Monosiga brevicollis MX1

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