2CR9


Conserved Protein Domain Family
WGR_PARP1_like

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cd08001: WGR_PARP1_like 
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WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
The WGR domain is found in a variety of eukaryotic poly(ADP-ribose) polymerases (PARPs). It has been called WGR after the most conserved central motif of the domain. The domain typically occurs together with a catalytic PARP domain, and is between 70 and 80 residues in length. It has been proposed to function as a nucleic acid binding domain. PARPs catalyze the NAD(+)-dependent synthesis of ADP-ribose polymers and their addition to various nuclear proteins. Higher eukaryotes contain several PARPs and and there may be up to 17 human PARP-like proteins, with three of them (PARP-1, PARP-2, and PARP-3) containing a WGR domain. The synthesis of poly-ADP-ribose requires multiple enzymatic activities for initiation, trans-ADP-ribosylation, elongation, branching, and release of the polymer from the enzyme. This subfamily is composed of vertebrate PARP-1 and similar proteins, including Arabidopsis thaliana PARP-1 and PARP-3. PARP-1 is the best-studied among the PARPs. It is a widely expressed nuclear chromatin-associated enzyme that possesses auto-mono-ADP-ribosylation (initiation), elongation, and branching activities. PARP-1 is implicated in DNA damage and cell death pathways and is important in maintaining genomic stability and regulating cell proliferation, differentiation, neuronal function, inflammation, and aging.
Statistics
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PSSM-Id: 153428
View PSSM: cd08001
Aligned: 36 rows
Threshold Bit Score: 104.599
Threshold Setting Gi: 196015654
Created: 21-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CR9_A         33 AHVLEKGGKvFSATLGLVDiv--kGTNSYYKLQLLEDdkenRYWIFRSWGRVGtv--iGSNKLEQMPs--kEDAIEHFMK 106  human
XP_001769461  515 GHIVEEGKViYTTTLNRSEla--tGINSFYVLQLIEEdakkTVHLYRKWGRVGnd-riGGDKIEKLSk---ADGIKEFKR 588  Physcomitrell...
EER19625      547 AHILVDGNVvYSETLSRTEaa--sGTNSYYIMELYEAdqgtGYWIHRSWGRTGnd-aiGGEKREKMAd--kKNAISAFEG 621  Perkinsus mar...
XP_002109056  340 HVIKEPDGSvYSVNLENGY-----RHHSYCKIQALQSnttnLCCIFHAWGDVNsk--kGETSVETGYs--kEEAMLIFDQ 410  Trichoplax ad...
Q9FK91        324 GKIFEKDGLlYNCAFSICDlg--kGRNEYCIMQLVTVpd-sNLNMYFKRGKVGdd-pnAEERLEEWEd--eEAAIKEFAR 397  thale cress
XP_001763226  330 VYKDTELEEeGGKIFENKDiiyncAFSIYAIMQLIEMpn-kAVYLYYKKGRVGdr-lhNTERLEEMDs--tRQAMREFVK 405  Physcomitrell...
XP_002108332  473 HIIADANGNiYSTVLEAKHdt--sDICSFYKIQALERhdslICCLIVITNIKHqlndkIDVIVEDGYs--kEEVKMAFDE 548  Trichoplax ad...
Q9ZSV1        508 AHILEDGKSiYNATLNMSDla--lGVNSYYVLQIIEQddgsECYVFRKWGRVGse-kiGGQKLEEMSk---TEAIKEFKR 581  maize
Q9SWB4        323 GKIFERDGIlYNCAFSVCDqg--rGLNDYCVMQLIVVpe-nRLHLYFKKGRVGdd-pnAEERLEEWDn--vDGALKEFVR 396  soybean
XP_002117683  325 DDYHVIEDS-NGIVYSVVLe---kTPCEFLKLQALKHnqlnHCCFVRIKDYVAg---iGEIRIEIEDglteIEAKMALDA 397  Trichoplax ad...
2CR9_A        107 LYEEKTGNAWHs-----KNFTKYPk-KFYPLEISG 135  human
XP_001769461  589 LFKEKTGNDWEswv-nrEDFEKQPg-KFYPLDIDY 621  Physcomitrella patens subsp. patens
EER19625      622 LFEEKTGNPFHevaaglLPFEMHPg-KAFRLDTKI 655  Perkinsus marinus ATCC 50983
XP_002109056  411 MYFEKTGNGFGk----eKKFVKMAr-KFYPVYLDV 440  Trichoplax adhaerens
Q9FK91        398 LFEEIAGNEFEpwe-reKKIQKKPh-KFFPIDMDD 430  thale cress
XP_001763226  406 LFETLTGNPFEpwe-reKKFEKKPm-KFFPVDMNS 438  Physcomitrella patens subsp. patens
XP_002108332  549 KYFELTGNRFEt----sVNFKKKAg-KMYPLDTTN 578  Trichoplax adhaerens
Q9ZSV1        582 LFLEKTGNSWEawe-ckTNFRKQPg-RFYPLDVDY 614  maize
Q9SWB4        397 LFEEITGNEFEpwe-reKKFQKKPl-KFYPIDMDD 429  soybean
XP_002117683  398 KYFQKTGYSFIn----gIQSKRKAqkLYYPIGTAY 428  Trichoplax adhaerens
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