Conserved Protein Domain Family
LigA_like_1
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cd07925: LigA_like_1 
The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB)
The proteins of unknown function in this subfamily are similar to the A subunit of the Protocatechuate (PCA) 4,5-dioxygenase (LigAB). LigAB belongs to the class III extradiol dioxygenase family, composed of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Dioxygenases play key roles in the degradation of aromatic compounds. PCA 4,5-dioxygenase catalyzes the oxidization and subsequent ring-opening of PCA (or 3,4-dihydroxybenzoic acid), which is an intermediate in the breakdown of lignin and other compounds.
Links
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Statistics
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PSSM-Id: 153395
Aligned: 9 rows
Threshold Bit Score: 171.833
Created: 21-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the family
  • Comment:The active site is located at the intersubunit interface. Most active site residues are from the B subunit.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #####    #   #   #  #  #    #                             #  #    ####  #  #  ##
YP_001238777  12 GTTIFDGEQARKGYALNKMCYSFNDAANRKAFVADEDAYCTKFGLNAQQRAAIKHRNVLELIEAGGNAYYLAKFAGIFGL 91  Bradyrhizobium ...
ZP_01115418    9 GNTFFNGEMAAKGYNLNKMFHSLNSAAGREAFRADERAYCEQYRLTPEQTETVLNRDLIRMIELGGSIYYMAKFAGVLGL 88  Reinekea sp. ME...
Q0KJL0        10 GTTLFDGGAARKGYALNAMCFSFNEKVNRDAFLADEASYMDRYGLTPEQRESVVGRDILGMIAAGGNIYYLAKLAGIFGL 89  Sphingomonas sp...
YP_982957     16 GTTQFDGEQARKGYALNKMCFSFNSADNRNAFKADEEAYMRQYGLNETQAAAIRARNVLQLIAAGGNAYYLAKFAGIFGL 95  Polaromonas nap...
Q2G8Z5       129 AIPLFDGDLATRGYELNAMCFSFNEKANREAFLADEEAYCRKFNLTPQQRKAVADRDVLAMLDAGGNVYYLAKLAGIFGL 208 Novosphingobium...
YP_001342753   9 GNIMFDGPMATKGYPLNKMCYSFNNADGREAFLANEDDYCEKFGLSVEQKQAVKNRDVIAMLEAGGSIYYLAKFAGILGL 88  Marinomonas sp....
YP_001342771  12 GTYLFDGQMAKKGYGLNKMCYSFNDQTARDEFNADPEAYCEKFKLTEAQKEAIRNRDVIGLLREGGSIYYLAKFTGLLKL 91  Marinomonas sp....
YP_003135608   8 GTHVFDAESSRRSYKLNKMFMSLRDPAARERFSADEAGYCDEFGLTPEQKQAVLDRDWKKMLDLGSSIFYVLKLAMIDKK 87  Saccharomonospo...
YP_572386     12 GTYVFDLALSRQGYAINKMCNSLKFDENREAFKADEEAYMERYGLSEEQKQAVRERDWLRLTQLGGNLFFFLKLGATLGY 91  Chromohalobacte...

Feature 1         ##  #  ##      #   ######
YP_001238777  92 DMQDIGAQQTGLTKDQFKAKLLAARG 117 Bradyrhizobium sp. BTAi1
ZP_01115418   89 NVQDVGGLQTGRSTEEFQAYLDSQGR 114 Reinekea sp. MED297
Q0KJL0        90 NVQDVGSMQTGVSVEKFKEMLLAQGR 115 Sphingomonas sp. KA1
YP_982957     96 DMQDIGAQQTGLTKDEFKARLIAAGQ 121 Polaromonas naphthalenivorans CJ2
Q2G8Z5       209 GVQDLGALQTGMSVADFKAMLVRWAD 234 Novosphingobium aromaticivorans DSM 12444
YP_001342753  89 NVQDVGGLQTGMTTDEFKAFLVQQGE 114 Marinomonas sp. MWYL1
YP_001342771  92 NMQDIGGLQTGMSTDEFKAMLEKNGR 117 Marinomonas sp. MWYL1
YP_003135608  88 SMQYLGGVFTGMTEEEFVAMMRAGGR 113 Saccharomonospora viridis DSM 43017
YP_572386     92 GLYTIGAQMRGESYEQFMSTRNVPGA 117 Chromohalobacter salexigens DSM 3043

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