Conserved Protein Domain Family
nitrilase_7

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cd07585: nitrilase_7 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143609
View PSSM: cd07585
Aligned: 13 rows
Threshold Bit Score: 333.899
Threshold Setting Gi: 170693336
Created: 12-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                        
ZP_01092282    3 RCATVQFQhhpgDKLYNLAQIETWCRRAAetgVQLITFPEMCVTGYwhvrsldragvaalaepvptgssTAALVDLASRY 82  Blastopirellula...
YP_001477717   6 RAATVQFQhranDKNYNLSVIEGFITRAAaeqIQVLTFPEMCITGYwhvrhlsageigalaepiatspsLARIRPLAERY 85  Serratia protea...
YP_001304645   5 KIATVQFEtrdnDKVYNLSVIREMCRKASvegADVVAFHECSVCGYtfakdlsreellaiaepiptgesTQALIAIAKEF 84  Parabacteroides...
ZP_01853771    5 RIAVVQFEhrngDKAFNLQRIRELSQQAVeqgAEIVSFHECCIPAYtfvqsfskeelldlaeqvpdgpsTRELMQISQEV 84  Planctomyces ma...
ZP_01120526    2 KIAVAQFEprdaDKSYNLSVITDLTRKAAtagAKVISFHEMCITAYthtrnldreallnlaesvpdgpsTRQLIGLARTT 81  Robiginitalea b...
ZP_04374890    4 RAATVQFEprpgAKEDNLARIEHFARAAAadgVQLVAFPEMSLLGYwhltkrdaayl-havaepddgpaITRISALAAEL 82  Catenulispora a...
ZP_02884496   21 RVASVPLVscrgQAAQNVARIADWLTLAAsrnIDLVVFPEACISGYasmaklnrael-nalaepldgpsVRAVMDAVERT 99  Burkholderia gr...
YP_516553      6 RIGLAQFEakvgDTERNLQEIIRTAEVASsqgVSLLCYPECALHGYspkdasei-------adpldsmaVARLRECARDL 78  Desulfitobacter...
YP_001113531   5 KIALVQMQatfgNIDKNLSTLEKFINEAAaqqAEIICFPEMCIQGYsreipdfl-------lqsidgeaILFLKKLAQNK 77  Desulfotomaculu...
ZP_01667672    8 RIGAVSCPaevnNLAANLAVIGNWTKKAAqagVKLLLFPELSLTGYatgsappt-------alssaspaWQAVADLARRY 80  Thermosinus car...
YP_358374     13 RLALVQSVseigDCTRNLEGIARWTEQAArqgAEMVCFPELAICGYtrsgigel-------aevvpgraSCHLAALARKH 85  Pelobacter carb...
YP_001528352   5 RIAAVTCAcpagQVDRNLETTARWVGKAAargAGIVCFPELNVSGYcldaalyre------aagryndvVGALSRMATAF 78  Desulfococcus o...
YP_002433295   6 RIAAAPMHcplwESDRNLQSVDAYAKEARicgAEVLVLPEMTLTGYcaseplpk-------alerdgreYQALSEIARSR 78  Desulfatibacill...
Feature 1                                             #   #   #                            ## ## 
ZP_01092282   83 QLIIGgGLI--EHaed-gqlYNTYVVALPDGavHRHRKLHCF--ISPYMSSGDqYTVFDTh----lGVKLGVLICWDNNL 153 Blastopirellula...
YP_001477717  86 NMAIGvGLI--EQged-gkyYNAYAVCLPDGklHVHRKLHAF--EHPAIASGDsFTVFDTp----wGVRMGVLICWDNNL 156 Serratia protea...
YP_001304645  85 GVTLLaGFF--ERdgd--riYKAQVCVDGNGlkAKYRKLHPF--INPNILPGDqYVVFEIk-----GWKCGILICYDNNI 153 Parabacteroides...
ZP_01853771   85 GVPILaGLF--EVdqd--evYNTYVCVDGNElvARFRKLHAF--VNSHLASGSeYVVFELr-----GCRCGILICYDNNL 153 Planctomyces ma...
ZP_01120526   82 GLTILaGLL--EVdhg--kvYNTYICVTGEGlvARYRKIHPF--INPHIEPGAeYCVFDLm-----GWKCGILICYDNNI 150 Robiginitalea b...
ZP_04374890   83 HLGIGfGLL--TArdg--wlFNAYAVCLPDGtvHIHRKLHAF--EHEAISSGSrYTVFDTp----wDVRVGVLICYDNNL 152 Catenulispora a...
ZP_02884496  100 GVAAGvGLI--ERatd-gqlFNSYLVCLPGGvrYCHRKLHAF--EHPRIGSGDrFTVFAAs----aGIRIGILIGADNYV 170 Burkholderia gr...
YP_516553     79 GLILLvGMV--EKspegkkpYISQLIVFPDRepEVYRKVHLGriEQHYFTAGDsFPIFAAg-----GVKFSIGICWDWHF 151 Desulfitobacter...
YP_001113531  78 GITIIaGMA--EKcln-krpFITQVVIRPGQniDYYRKTHLGnsEQPYYQAGNeIKTFSTe-----KTTIGIQICWDTHF 149 Desulfotomaculu...
ZP_01667672   81 CITLAvGLVwqEDaak--ppYLAHGLWTPSGqvHLYCKSHLGerEKKHYAAGDfLPVFALp-----EARVGFQLCLEQHY 153 Thermosinus car...
YP_358374     86 RMVVSaGLI--EKsgs--acYITQLVASADGsiERYRKTHLGrrEREVFCAGDaLPVFTTrsragmPITFAIGLCYDLHF 161 Pelobacter carb...
YP_001528352  79 DIVILaGTVa-EAagg--rvTACHLVISPNGsaGGYTKLHIAppEKQLFVPGRkVPLFEAk-----GAVFGVQLCYDAHF 150 Desulfococcus o...
YP_002433295  79 RLTVLaGLA--EVgpr-gnkYATHLACFPDGrvFFHRKTHLStvEEAWLTPGSeLPVFRNs-----HYAFGIQLCYEAHF 150 Desulfatibacill...
Feature 1                           #                                                            
ZP_01092282  154 TEnARITALQGADILLAPHQtggtasrsphamgkidpqlwhdraqnpaalqaetnggkgreWLHRWLPSRAHDNGMFLLF 233 Blastopirellula...
YP_001477717 157 VEnVRATALLGAEVLLAPHQtggthsrsphgmkpiplevwqqrqtnpaaieaafrgehgrgWLLRWLPARAHDNGLFVLF 236 Serratia protea...
YP_001304645 154 IEnVRATALLGADIIFMPHVtmctpsprpgaglidpvlwe-nrandptslrqefdglkgraWLMKWLPARAYDNAVYVVF 232 Parabacteroides...
ZP_01853771  154 VEnVRMTAMLGADIIFMPHVtcclpsvmpgrglvdpslwh-nrardpvrlrqefqgpkgkgWLMKWLPARAYDNGVYAIF 232 Planctomyces ma...
ZP_01120526  151 IEnVRATSLLGAELIFAPHVtgctpsampgrgyvahelwe-nrdthpdilraefqgpkgrgWLMRWLPARAYDNGVFYAF 229 Robiginitalea b...
ZP_04374890  153 VEnVRATALLGAQILLAPHQtggtnsvsphgmkpiplsvwenrhadpaaaeeafrgpngreWLLRWLPSRAHDNGLFVVF 232 Catenulispora a...
ZP_02884496  171 VEnVRMTALMGATLLIAPHRtygvsgegsewiqpmsmeqa-lnrasianvarceaacsaekWLCRWLPARAVDNGMFVVF 249 Burkholderia gr...
YP_516553    152 PElSAICSLKGAEIQFAPHAspvvs-------------------------------gdrkeIWKRYLGARAYDNSVYLCA 200 Desulfitobacter...
YP_001113531 150 PEmTTILSLRGAEVIFAPHAsptiv-------------------------------gdrkaIWLKYLAARAYDNSVFLAA 198 Desulfotomaculu...
ZP_01667672  154 PEiTQTLALRGAELILCPHAtprltp------------------------------aerrdSWHISLRARAYDNCVYILA 203 Thermosinus car...
YP_358374    162 PElATAYAVQGAQLLLAPHAaphag-------------------------------pdrmqLWQRYMGARAYDNTMYVAA 210 Pelobacter carb...
YP_001528352 151 PElSTAMALKGADILFVPHAsprntp------------------------------eeklaSWMRHLPARAYDNGVFVAA 200 Desulfococcus o...
YP_002433295 151 PElTTNMALAGAHILFIPHAsprgtp------------------------------qekeeSWLRHLTARAYDNGLYVAA 200 Desulfatibacill...
Feature 1                                                                                   
ZP_01092282  234 SNgvgldd-devrtGNAMILDCY-GRILAEQLep--tdAMVTADVDLDLLENCTGRRWI--------RGRRPELY 296 Blastopirellula mari...
YP_001477717 237 SNgvgrdd-devrtGNAMILDPY-GRILAETWaa--enQMVTAELDLSLIPLSTGRRWI--------HGRRPALY 299 Serratia proteamacul...
YP_001304645 233 SNpigrdy-neiknGCSMILDPF-GDIVAECRkl--gdDFVIATAIPEKLRQAGGYRYR--------NARRPELY 295 Parabacteroides dist...
ZP_01853771  233 TNpvgmdd-qevkpGLSMILDPF-GEIIAECTrl--gdDIAIALCTDEKLHQAGGRRYI--------RARRPDLY 295 Planctomyces maris D...
ZP_01120526  230 SNpigydg-dhlknGNAMILDPY-GEILAETEsf--daQIATAQLDRKKLELAGGTRYK--------RARKPSLY 292 Robiginitalea biform...
ZP_04374890  233 SNgvgrdd-devrtGNAMIIDPY-GRILAESWaa--adAMVTADLDLDLVPTSTGRRWL--------RARRPELY 295 Catenulispora acidip...
ZP_02884496  250 IDgadiag-qpkraGAAMIVDPF-GRTLADMSsgettgGLVYAELDTRLIGVSPGREWL--------GARRSNLY 314 Burkholderia gramini...
YP_516553    201 CNlvgtnnrdkefsGGILVFGPK-GEVLAENQdt--qeQLFVVDLPAKPINTLRSPKRQsmrdtfflADRRKELY 272 Desulfitobacterium h...
YP_001113531 199 CNlvgddgngrqfcGGSMVIDPK-GNVLAEDFeg--kqSMLVVDLDCAQINAIRERKSSsmansfflANRRPEIY 270 Desulfotomaculum red...
ZP_01667672  204 TNmvgdngqgveypGGLLLVDPA-GQVVAEDFsg--rpAMIVDDIDLSRVVNVRTTPQGmcrr-fyaPSRRPELY 274 Thermosinus carboxyd...
YP_358374    211 CNhvqklk-ssdcsGGLGVWDYRtGTLLAQRTep--geGLLFWDLDLDGVNRTRAQGRTff-----lDDRRPELF 277 Pelobacter carbinoli...
YP_001528352 201 CNqagengagqgfpGVAVALDPS-GKVMAQTTsp---dSMIVADCSPSTLNTVRNHPMRyf-----lPGRRPELY 266 Desulfococcus oleovo...
YP_002433295 201 VNqsgenqaglsfpGVALVLDPL-GRVEARLQgg---eGLLIADLRADLINQVRSHRMTsf-----lSRRRPEVY 266 Desulfatibacillum al...

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