Conserved Protein Domain Family
Peptidases_S8_BacillopeptidaseF-like

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cd07481: Peptidases_S8_BacillopeptidaseF-like 
Peptidase S8 family domain in BacillopeptidaseF-like proteins
Bacillus subtilis produces and secretes proteases and other types of exoenzymes at the end of the exponential phase of growth. The ones that make up this group is known as bacillopeptidase F, encoded by bpr, a serine protease with high esterolytic activity which is inhibited by PMSF. Like other members of the peptidases S8 family these have a Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity.
Statistics
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PSSM-Id: 173807
View PSSM: cd07481
Aligned: 13 rows
Threshold Bit Score: 353.99
Threshold Setting Gi: 145592837
Created: 12-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                                                         #            
P16397             218 GTGTVVASIDTGVEWNhpalkekyrgynpenpNEPENEMNWYDAvag-----------easPYDDLAHGTHVTGTMVgse 286  Bacillus...
AAK39096           169 GDGIVVGIIDSGVRHThkr-----------lsSNWRQEYGWFDPydn-----------telPNDPWSHGTHVTGTIVgth 226  Aphanomy...
YP_001547411       224 GQGIVVANIDTGVTVShtallnn---yrgwsaNGLSNDYNWFDPlyq-----------yrlPTDPAGHGTHTMGSLVgan 289  Herpetos...
YP_001545962       176 GQGIVIAGEDTGVRWThaalksk---yrgwdgTNASHDYNWYDGirtslggtnpcglalnvPCDDNSHGTHTVGTVVgdn 252  Herpetos...
YP_074547          222 GTGVVVANLDTGVDGThpalaa-----qyrgnGASDHSAFWLDVvnr-----------rpqPYDDDGHGTHTMGTMVgrt 285  Symbioba...
YP_846396          181 GQGAVVAGQDTGYQWDhpalkrq---yrgwngTSADHDYNWHDAvhsggdgt--cpadspvPCDDYGHGTHTMGTMVgdd 255  Syntroph...
YP_001535288       183 GEGIVIANIDTGVQYDhpalvns---yrgnlgDSFDHAYNWFDPagic---------pgsePCDNNDHGTHTMGTMVgdd 250  Salinisp...
YP_001636230       242 GSGITVANIDSGVQYThpalvnq--yrgnlgsNTFDHNYNWFDPvgn-----------qpaPVDAGTHGTHVMGTMVanp 308  Chlorofl...
YP_001157134       517 GTGVTVGSSDSGVDGNhpa----------lgaGFRGGDDSWFDPwna-----------tsaPRDRNGHGTHTLGSAVgrd 575  Salinisp...
YP_001431680       485 GKGVVIGLMDSGVQWDhpelrds--yrgvrtdGTVVHEYNWYDPwgg-----------ttePVDYSGHGTFTLSAAVgnr 551  Roseifle...
REF_jgi:Caur_0649  934 GEGVVVGSIDTGAKLDhpllnan--yrgrypdGSYDHSYSWFDPtgtf----------pdaPGDDNGHGTHTIGTMVgid 1001 Chlorofl...
YP_001635209       473 GAGIVIGQADSGVDGAhpelrds---yagqtpNGIDHVYHWLDPwtn-----------apePYDASGHGTHTLATILgnr 538  Chlorofl...
ZP_03729727        201 GDGVVIGIIDTGVDWHhealrek---wrgydgGSIDPDFNWFDAvnq-----------halPIDLNNHGTHVTGTILgsv 266  Dethioba...
Feature 1                                             #                                     #          
P16397             287 pdgtnqigvapgaKWIAVKafsedg-gtdadILEAGEWVLAPKDaegnph--------pemapDVVNNSWGggsg----- 352  Bacillus...
AAK39096           227 gig-----vapnaQWIACKawnttm-nirrlLVKCAQFMLCPHDrygnna-------dcskapHVINNSYGsysk----- 288  Aphanomy...
YP_001547411       290 dqqgmalgvapaaRWIAARacgalt-cddlsLIRSAQWMLAPTRvgcernqqiacdprpdlrpHIINNSWGgpge----- 363  Herpetos...
YP_001545962       253 gtgeq-igvapgaKWIACRnmdagn-gtpatYIRCIDWMLAPFPtagtsaq-----gdpskapHVVNNSWGclasegctn 325  Herpetos...
YP_074547          286 pdgqvqigvapgaQWIAVKildetgsgytswILEGAQWLLNPGGdpa-------------napDVVNNSWGggpg----- 347  Symbioba...
YP_846396          256 gdadr-igmapgaRWIGCRnmdngm-gtpatYAECFQWFIAPTRmdgsda-------dpamapDVINNSWSctpgeg--c 324  Syntroph...
YP_001535288       251 gagnq-igvapgaRWIAAKgceart-csdpsLLAAGQWILAPTDangenp-------rpdlrpDIVNNSWGgpsg----- 316  Salinisp...
YP_001636230       309 pgepa-mgvapgaRWIAARacssvt-cndsdIIAAAQWMLAPTDlagnnp-------rpslrpHILNNSWSfdsg----- 374  Chlorofl...
YP_001157134       576 gvg-----vapgaTWTGCVnldrnl-gnpalYLDCLQFMLAPFPsggdpfhd----grpqrapEIITNSWScppleg--- 642  Salinisp...
YP_001431680       552 vg------vapdaTWIACVnlarnv-gnaarYLDCMQFMLAPFPpngdplrd----gdpalgaDVTNNSWGcpqdle--g 618  Roseifle...
REF_jgi:Caur_0649 1002 gig-----vapgaRWIAARacsrra-cqdidILRAMEWMLAPYPstlgpva-----anpdmrpQVVNNSWGgpgg----- 1065 Chlorofl...
YP_001635209       539 vg------vapeaTWIGCVnlarnl-gnaprYLDCMQFLFAPYPpagdpfrd----gdptrgaHILNNSWGcptdfe--g 605  Chlorofl...
ZP_03729727        267 eemqgyfgvapeaKWIAANafgsdgtakssdILAAAQYMLAPTDingvah--------pdkapDVINNSWGgnvpg---- 334  Dethioba...
Feature 1                                       #                                                      
P16397             353 -ldewYRDMVNAWRAadIFPEFSAGNTdlfipggpgs----ianpanypeSFATGATDINKKLADFSLQGPspy---deI 424  Bacillus...
AAK39096           289 -enfwMEDTIAAWRAagIVPVFGNGNNgprctnld--------ypaaspqVIAVGATDRNDFLYDYSSLGPsmk---nsT 356  Aphanomy...
YP_001547411       364 --stwYSGYITAWDAagILSVFAAGNFgrsgcyts-------tapgnnanVFSVGAVDINNLIADFSSRGPtsd---grT 431  Herpetos...
YP_001545962       326 tpsdgIQTSVQNVTNagIMFVASAGNDgsgcatit-------tpvaiypeSFVVGSHTSTGAISGFSSRGPatnngasrI 398  Herpetos...
YP_074547          348 -inewFRSVVEAWRAagIVPIFAAGNSgpepgtva--------vpanypeSIAVGNIRKDDVLNGSSGRGPtpy---geI 415  Symbioba...
YP_846396          325 edpnvLLTVVNNVRAagILTVQSAGNAgapcetvm-------dpaaiyraSFTVGATDRSDVIATFSSRGPvtsdgsnrR 397  Syntroph...
YP_001535288       317 --dpwYQQTVDAWRAagIFPVFSAGNSgpgcgsag--------spgdypnSYAVGAYGSNGAIANFSSRGSgt----dpI 382  Salinisp...
YP_001636230       375 -gnpvYSGYTTAWQAagIFVVFAAGNIssnfttcss-----vaspgdysnVVAVGATDQNDLLSYFSRIGPttd---grI 445  Chlorofl...
YP_001157134       643 cdlgaLQPAVAALAAagILVVFAAGNSgprcrsie-------dsptadpeVLTVGAVDRQRRVTDFSARGPvpg---dgA 712  Salinisp...
YP_001431680       619 cdpntLLPAAESLRAagMVTVAAAGNDgpacssln-------aplalydaVLTVGAVQRDGIVAPFSSIGPvladgsgrI 691  Roseifle...
REF_jgi:Caur_0649 1066 --rplFQQMVAVWRAagIFPAFAAGNCgqarpgclvtgvgsvsspgdyaeSFATGATHDNDTLAAFSSQGPsrl--tsnV 1141 Chlorofl...
YP_001635209       606 ctptsLQPAVQALRAagVFVVASAGNDgpscssln-------aplaiyddVMTVGAVNSAGQLAPFSSVGPvtsdgslrP 678  Chlorofl...
ZP_03729727        335 endewFRPMVQAWRDaqILPVFAAGNLgtygsgsi-------shpanypeSFSVAATDNNDYLAMFSSRGPspy--fdnI 405  Dethioba...
Feature 1                                             #                                    
P16397             425 KPEISAPGVNIRSSvpgq----tyeDGWDGTSMAGPHVSAVAALLkqanas--lsvdeMEDILTSTAE 486  Bacillus subtilis
AAK39096           357 KPDISAPGVDIRSAsivs---dvdyWSNTGTSMAAPHVSGAIALYlsankgasynevyTALANNVDTD 421  Aphanomyces astaci
YP_001547411       432 NPDLSAPGVRVPSAwpn-----gstALLDGTSMAAPHVSGIAALIwsanpqyigdlaaTQALLTNTSE 494  Herpetosiphon aurant...
YP_001545962       399 GPDISAPGSSVRSAtngg---ddvyGSSSGTSMASPHVVGVVALLwsarpelqgqvdlTRAILQETAT 463  Herpetosiphon aurant...
YP_074547          416 KPEVSAPGTLVRSAlpg-----glyGLMNGTSMAAPHVAGVAALLrqadas--ltvdeIEEILTGTAE 476  Symbiobacterium ther...
YP_846396          398 KPDISAPGVSIRSSfkg-----ggySIMSGTSMAAPHVAGLAALLvsansrlsgqvdlLERIAERTAL 460  Syntrophobacter fuma...
YP_001535288       383 KPNVAAPGVAVRSSvpg-----ggyAAFNGTSMAAPHVAGTVALIwsvasslrgdltaTEALLDRTAR 445  Salinispora arenicol...
YP_001636230       446 KPDLVAPGQGIVSTvtstitdantfGALSGTSMAAPHVAGAVALLwsakpqligdydaTYALLTGTAL 513  Chloroflexus auranti...
YP_001157134       713 KPDLVAPGGDVLSAlpg-----ggyGVFSGTSMATPQVAGVAALMwaanpaligdlprTRQILTETAT 775  Salinispora tropica ...
YP_001431680       692 KPDIAAPGANVLAAapg-----sgyMTGSGTSIAAPHVTGVVALMwsanptligdverTEEMLRTTAQ 754  Roseiflexus castenho...
REF_jgi:Caur_0649 1142 KPDLVAPGVAIESAaln-----ggtLPQNGTSMASPHTAGAVALLlslrpg--laidqLEALLRTTAR 1202 Chloroflexus auranti...
YP_001635209       679 KPDLVAPGTNILSAfpe-----qsyAYADGTSMAGPHVAGAVALIwsanpaligdietTEQILRETAR 741  Chloroflexus auranti...
ZP_03729727        406 KPDISAPGVQILSSitg-----geyGYSSGTSMAAPHVAGVAALLleakpe--ltieqLEEVIKDTSR 466  Dethiobacter alkalip...

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