Conserved Protein Domain Family
Peptidases_S8_Subtilisin_like

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cd07473: Peptidases_S8_Subtilisin_like 
Peptidase S8 family domain in Subtilisin-like proteins
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173799
View PSSM: cd07473
Aligned: 59 rows
Threshold Bit Score: 258.277
Threshold Setting Gi: 113475692
Created: 2-Mar-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic triadputative active
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #                                                                    # 
ABD14413      157 SRDVVVGVIDTGVDYSHPDlaanawvnsg-eiagdgidnDGNGYIDdvhginait-------------dvgdpmddeGHG 222  Pseudoalterom...
YP_721753     270 SPKVRVAVIDTGVDVDHPDlinnldl------saarnfvDGYNNTDniske---------------------vedldGHG 322  Trichodesmium...
CAJ76907      171 NQDVVVGVIDSGIDYNHPDlinhmwintaeanglpgvddDGNGYTDdiygydfga-------------ddsdpmdigDHG 237  Clostridium t...
YP_001560784  179 TRQVIVAIVDTGIDFEHPDlkdhmwinpn-eiagdgidnDNNGYVDdiygwdfynndntic-hydtktmtaskedndDHG 256  Clostridium p...
ZP_02084885   173 KRPLTVAVIDTGVDISHPDlqgsiwvned-eipgdgidnDGNGFVDdvngwnfysn-----------tnqvyegpedVHG 240  Clostridium b...
ZP_02429609   125 DSSISVGVIDTGIDQNHPDirenmwt------twngrliYGWNFADnssds----------------------mdidGHG 176  Clostridium r...
EEE21708      467 QKRLTVAVIDSGVDYRHPDlknmiwhneg-eicnngiddDRNGLVDdclgwdfih-------------gdndpdddnGHG 532  Toxoplasma go...
ZP_02417649   207 TQKVIVANIDTGVDYSSPDlksvmwknp--kekkngkdsDKNGYKDdiygwnfynnnnkvfsnkyyrvskeyvsyedDHG 284  Anaerostipes ...
YP_503374     205 SGDVIVAVLDTGIDYNHPDlksnmw--------tgssgeHGFNVITqtqdp----------------------mddnGHG 254  Methanospiril...
ZP_02419454    74 VKNIIVAVLDTGIDKTDPNikksiyknk--nekldgrdnDHNGYIDdisgwdfyhkn----------ntvyddyisdAHG 141  Anaerostipes ...
Feature 1                                                                                         
ABD14413      223 THVSGTIGasgnngvg--vvgvnhdvSIVGCKflaadg----tgstsgAIKCIDymvglknagvnlRVLNNSWGgggf-- 294  Pseudoalterom...
YP_721753     323 THVAGIIGaignnneg--ivgvswnvEIVPIKafdfdenddpigfdadIIEAIDyain----daqvDIINASWGkpvgtp 396  Trichodesmium...
CAJ76907      238 THCAGIIAgfg------------pnvKIASLKhlsgnkf---kdldnwVSTMIKainya--damdiKIVNVSLGlhksqi 300  Clostridium t...
YP_001560784  257 THCAGIIAasannqigiagvasnidvKIMSLKihggekg---kgtisnAIKAIKyatm-----mgaDICNLSWGst---- 324  Clostridium p...
ZP_02084885   241 THAAGTIAaskdnggiv-giadnnyvKIMPVKalggeeg---kgspdnVIAAIKyaka-----ngaQICNLSFGsqnc-- 309  Clostridium b...
ZP_02429609   177 SHVAGTIGavgnnrig--itgvcwqvRVAALKfgld---------vasAIAAIDfany-----ykiSILNASWGgr---- 236  Clostridium r...
EEE21708      533 TASAGIIAaepnnhig--magicwgcEIMILKalnkdi----kgtvssFARAIDyalg-----kgvKISNNSYGgrgsg- 600  Toxoplasma go...
ZP_02417649   285 THGAGTIAavrnngygiagiasgtnvKLMSIKvlggkkg---egttlsVIKGIKyakk-----mgaKICNFSFGsyqn-- 354  Anaerostipes ...
YP_503374     255 THCAGIIGavgnngvg--gsgiawqtKLMAIKaigadg----kaytsdIIKGIEyatk-----agaDIISCSFGgsds-- 321  Methanospiril...
ZP_02419454   142 TYIANILAgshqkdsy---fgvapgiTILPVKilhgad-----gnledIPEAIDyayn-----rgaRIFNCSFD------ 202  Anaerostipes ...
Feature 1                                                                                         
ABD14413      295 --sqalADAITASEqa------dILFVAAAGNDavdnd-----qnphYPs---nYENDNVLSIASTDsrdnmssfsqwgl 358  Pseudoalterom...
YP_721753     397 -yskelKEAISNVNhpsg--rvpPLFVAAAGNEsndndna-nlkmrtYPa---sYDLNNIISVAATDhndrlspfsnygr 469  Trichodesmium...
CAJ76907      301 gdrpfdSQALNDAIsn-----adLLFVTAAGNFnknidl---pddviYPa---sCTAENIITVANTDkddklyessnygv 369  Clostridium t...
YP_001560784  325 ----tyNQALEQTIke-----spMLFIAAAGNNgknnd-----eipvYPa---sFSLDNIISVTFVSptgaltvksnyga 387  Clostridium p...
ZP_02084885   310 --teefKAAIRDSG---------MLFIVAAGNGddnaigynidaspiYPa---sLPFDNVITVANLMfdgkldessnfga 375  Clostridium b...
ZP_02429609   237 ----aySQALKDAIdq-----ydGLFVASAGNDgtnnd-----vdpmYPa---sYDCKNIISVAAVDpydtlarfsnygl 299  Clostridium r...
EEE21708      601 --fhglEQAVERARaa------gMIFVAAAGNYngnndn---dkdpvFPa---sYQLDNIISVAAITragslanfssygk 666  Toxoplasma go...
ZP_02417649   355 --drmlRDVIKENKd--------MLFICAAGNErnn--------ndrYPvypasYNYSNVISVANLDyngyldgysnygk 416  Anaerostipes ...
YP_503374     322 --sqglYDAIAESP---------ALFVCAAGNQgknnd-----qtphYPs---sFQLPNIIGVAATTssdtlv-stsnyg 381  Methanospiril...
ZP_02419454   203 ------FEANNKAIykkmkkysdAVFVCAGGKAgvn--------ldkYPiypacYQLKNIISVGAINskgely-nasgyg 267  Anaerostipes ...
Feature 1                                                        #                                
ABD14413      359 TSVDMGAPGsgils--------------------tvpgnSYATYSGTSMATPHVAGAAALVlsvnpd------------- 405  Pseudoalterom...
YP_721753     470 KSVDLAAPGgsnlpdnnnnphdssdiystvpvgtgidggNYEYSAGTSAAAAYVSGAAALMlgtrrarrqtypvgspmye 549  Trichodesmium...
CAJ76907      370 ISVDLAAPGtdirstip--------------thlageggPYDIKTGTSMSAPHVAGAAALLlssnps------------- 422  Clostridium t...
YP_001560784  388 NSVDIAAPGvdils---------------------tvvgGYRTFSGSSMAAPHVSGIAAILystatk------------- 433  Clostridium p...
ZP_02084885   376 GSVDIAAPGtfilg--------------------itpdnGYAFMSGTSMAAPMVTGTAAMLytsrpe------------- 422  Clostridium b...
ZP_02429609   300 KTVDIAAPGtnils--------------------ldlagEYSPLNGTSMAAPHVAGAAALLkssmpn------------- 346  Clostridium r...
EEE21708      667 TQVDIAAPGaqims--------------------tslsgTYRTVEGTSFAVPFVSGAVALVwsrfpy------------- 713  Toxoplasma go...
ZP_02417649   417 KSVLLAAPGtdifg--------------------lgvreRGIIESGTSMAAPMVTGTAALIyakypg------------- 463  Anaerostipes ...
YP_503374     382 TTVHLAAPGedlysta----------------lsvpgggQYRYMTGTSQATAFVAGMASLVksldss------------- 432  Methanospiril...
ZP_02419454   268 KIIDIYAPGeniev--------------------eigkgDRTFVDGTSAATAYVSGAFALLksidsk------------- 314  Anaerostipes ...
Feature 1                            
ABD14413      406 ----lttleLKELLMSSGD 420  Pseudoalteromonas sp. SM9913
YP_721753     550 alddlsaveLKDKILKITT 568  Trichodesmium erythraeum IMS101
CAJ76907      423 ----lttqqLKDLILSSVD 437  Clostridium thermocellum
YP_001560784  434 ----lypsnVKEVLLMNYK 448  Clostridium phytofermentans ISDg
ZP_02084885   423 ----lsltdIKNVILASAR 437  Clostridium bolteae ATCC BAA-613
ZP_02429609   347 ----istitLKRIILSSAM 361  Clostridium ramosum DSM 1402
EEE21708      714 ----lpyreVIDRILRNAK 728  Toxoplasma gondii GT1
ZP_02417649   464 ----vtpamVKSALKRGAT 478  Anaerostipes caccae DSM 14662
YP_503374     433 ----lsneeIRSLMISHSD 447  Methanospirillum hungatei JF-1
ZP_02419454   315 ----isndeIKDIIIKYSY 329  Anaerostipes caccae DSM 14662

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