1IJY


Conserved Protein Domain Family
CRD_FZ5_like

?
cd07456: CRD_FZ5_like 
Click on image for an interactive view with Cn3D
Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 5 (Fz5) and frizzled 8 (Fz8) receptors, and similar proteins. This domain is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
?
PSSM-Id: 143565
View PSSM: cd07456
Aligned: 11 rows
Threshold Bit Score: 233.059
Threshold Setting Gi: 86563956
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative Wnt
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                # ### ###                                                               
1IJY_A         9 ACQEITVPLCKGIgYEYTYMPNqFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLeDYKKPLPPCRSVCER 88  house mouse
Q9VVX3        63 RCEEITIPMCRGIgYNMTSFPNeMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLeDYHKPLPVCRSVCER 142 fruit fly
NP_001079217  32 VCQEITVPMCKGIgYNHTYMPNqFNHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLCSMYTPICLpDYRKPLPPCRSVCER 111 African clawed ...
XP_002406904   1 RCEDITIPMCKGIgYNQTSMPNqFNQDTQDEAGMEVHQFWPLVEIQCSDDLKFFLCSLYTPICMeEYAGSVPACRSVCER 80  black-legged tick
ACA96797      97 KCIPIEIPLCKNIgYNLTYMPNaFNHETQEEAGLEVHQFYPLVEINCSEDLRLFLCSMYTPICLpTWHYRLTACKSLCES 176 Schistosoma jap...
NP_503965     24 KCEQITIPLCKGIgYNMTSFPNsYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQeNYDKPILPCMELCVE 103 nematode
CAJ29888      37 KCEPITVPMCRDIgYNMTYMPNhFNHDSQEEAGLEVHQFYPLVEIQCSPDLKFFLCSMYTPICLaDYHKPLMACRSVCER 116 common urchin
XP_002221998  30 VCEEVTIPMCKGI-YNYTYMPNkFHHQNQDEAGLEVHQFWPLVEIQCSPALKFFLCSMYAPICLeDYDHPLPVCKNVCQM 108 Florida lancelet
XP_001634995  28 KCEEITIPMCRGIgYNLTYMPNmFNHDTQAEAALEVHQFWPLVEIQCSPDLRFFLCSMYAPLCEkHYDKDLPPCRSVCER 107 starlet sea ane...
BAD93241      35 RCEDLVMPLCRGLwYNRTRMPNmFNHETQEEAGHQAQQFMYLVTIKCSPDLHFFLCSIYTPICVeNYDKPLPPCRSICQR 114 Dugesia japonica
CAF94116      17 VCEPITVPMCKGIgYNLTYMPNqFNHDTQEEVGLEVHQFWPLVRIRCSPDLLFFLCSMYTPICLpDYRKPLPPCRSVCER 96  spotted green p...
Feature 1                                                   
1IJY_A        89 AKAGCAPLMRQYGFAWPDRMRCDRLPeqgn---pdtlCMDYER 128 house mouse
Q9VVX3       143 ARSGCAPIMQQYSFEWPERMACEHLPlhgd---pdnlCMEQPS 182 fruit fly
NP_001079217 112 AKAGCSPLMRKYGFAWPERMNCDRLPehgd---pdtlCMYYNW 151 African clawed frog
XP_002406904  81 ARAGCAPIMRQYGFAWPERMNCDALPqygd---qeqlCMDAKE 120 black-legged tick
ACA96797     177 ARDGCMPVMRTYGFGWPERMNCDLLPeg-------neCVSRSN 212 Schistosoma japonicum
NP_503965    104 ARSKCSPIMAKYGFRWPETLSCEALPkmsdqmstgniCAAPPD 146 nematode
CAJ29888     117 AKAGCAPLMRQYGFAWPDRMQCENLPefgd---pdnlCMDSNH 156 common urchin
XP_002221998 109 ARDGCAPIMRQYQFAWPDKFECDDLPeqgd---pdrlCMHFLN 148 Florida lancelet
XP_001634995 108 ARTGCAPLMRKYGFSWPERMKCENFPelgd---entlCMGRNS 147 starlet sea anemone
BAD93241     115 SKDGCTPIMRNYGFSWPSQMSCDQFPegst---dkqlCMERDI 154 Dugesia japonica
CAF94116      97 AKQGCSPLMSQYGFEWPERMSCEKLPqlgd----evlCMDQNG 135 spotted green pufferfish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap