1T90


Conserved Protein Domain Family
ALDH_F6_MMSDH

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cd07085: ALDH_F6_MMSDH 
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Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.
Statistics
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PSSM-Id: 143404
View PSSM: cd07085
Aligned: 55 rows
Threshold Bit Score: 647.653
Threshold Setting Gi: 71893575
Created: 30-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1T90; Methylmalonate semialdehyde dehydrogenase from Bacillus subtilis with bound NAD+, defined using 3.5 A.
    View structure with Cn3D
  • Comment:The enzyme exhibits a half-of-the-sites reactivity, with two subunits being active per tetramer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1T90_A         6 LKNYINGEWVESKtdqYEDVVNPATKEVLCQVPIstKEDIDYAAQTAAEAFKTWSkVAVPRRARILFNFQQLLSQHKEEL 85  Bacillus subtilis
YP_357913     14 LQYCIDNEWRDSKtekYMAIMNPSLGVQIAETPCctTEEVEAAVQSAKAAFPGWSsKPAAIRTQILFKFRDLVNDHFDEL 93  Pelobacter carb...
ZP_02443510    7 MKYCVNGEWKDSKttkWLPVSDSSTGEIIAEVPCctQDELEEAIAAAHAAFPAWSlMSLSARTQMMFKWRNILMAHLDEL 86  Anaerotruncus c...
YP_065651      5 LQYWVDNQWRRSKttsYADLYNPSTGEVTAQVAHctAEEVEEAIASAAAAYPGWAaTPVGKRVQIFFRMKMLVDQHLEEL 84  Desulfotalea ps...
ABB84834      25 CHNWIGGEWSPATdgqTLDVVNPRHGAVMGSVAMsgATDVARAVSAASAALTAWReTPMKERGQVFYRLKRLMTDNLEEL 104 uncultured delt...
ZP_01906282   21 AKNFIGGEWVDGPs-eTLEVINPRHGKVMSRTPMsgAAEVDAAVQAAAAAYADWRaTPMRERAQVFYRLRDRMVAEREAL 99  Plesiocystis pa...
YP_628404     13 CRNLVGGSWQVPPgaaHLDVRSPYTGTVIGRVPLtpASGVAQAVEAAKAAAAAWKnTSLRERTQYLYRFRQFLERDLDAL 92  Myxococcus xant...
NP_968421     12 CQNFVSGKFLKGSg-lAMDVVSPYNGQIIGNLHAstAKDIDLAIKDAHETQKSWAdVPLKERTKIMFNFRQILMRDLDEI 90  Bdellovibrio ba...
NP_342675     15 LKLYINGEFIDSKtdtIGKAYNPAKDEIIAEVPFsaKDEVEEAIQSAQEAFEKWReVPITTRIQYLFALKNRLEEYSETI 94  Sulfolobus solf...
YP_001736933  13 LKLFINGKWVESSsreYAEVYDPGLGKVIAKVPMatEAEVDEAVEAAYEAFKSWSkLPVPDRLQYIFKMKYAMEERKEII 92  Candidatus Kora...
Feature 1                                                                        ####        #   
1T90_A        86 AHLITIENGKnTKEALGEVGRGIENVEFAAGAPs-lMMGDSLASIatdVEAANYRYPIGVVGGIAPFNFPMMVP-CWMFP 163 Bacillus subtilis
YP_357913     94 ATILATEMGKnLNEARGDVHKVVEACEVAVAAPl-eMQGHSTMEVtrgHDSVLYREPVGVFLGIAPYNFPAMIPfGWFIP 172 Pelobacter carb...
ZP_02443510   87 TLLCAKELGKtLNEARGDVLKAIEPTELACATPf-iSQGSASMQVttgFDTASYRVPLGVVAGIVPFNFPAMIPwGWMVP 165 Anaerotruncus c...
YP_065651     85 TDILCREQGKnRAESMGDVLKVNEVIEFACGAPh-lMKGPSLFNVsngYDTVQQMRPLGVFAGIVPWNFPAMIPhGWMAP 163 Desulfotalea ps...
ABB84834     105 SWLVSHENGKtIAQARGSVLKAIECVEMGTALPn-mAAAGQLDVSr-gVNCSTTYEPLGVVAGIVPFNFPMMVP-LWMIP 181 uncultured delt...
ZP_01906282  100 AWLISHENGKvYSQALAEVDKAVECVEFGCSLPn-lAAGTQLDVSr-gVNCQISYEPRGVVAGVTPFNFPLMVP-LWMLP 176 Plesiocystis pa...
YP_628404     93 AQLAASEAGKtVAEARAGLLKGMEVCDFALSLQn-lDTGAHLEVSr-gISCEYRREPLGVVAGITPFNFPAMVP-MWMFP 169 Myxococcus xant...
NP_968421     91 AHLKSSESGKtFAEGKAGLMKGIEVLEFALSLQn-mDLGGKMEVSr-gVSCEFRREPLGVIANITPFNFPAMVP-MWTIP 167 Bdellovibrio ba...
NP_342675     95 ARIIVQNHGKtIQEARGDMRRTIENVEAAISAAytlYKGEHLDQVsqeVDETVVREPLGVFGIITPFNFPTMVP-FWFLP 173 Sulfolobus solf...
YP_001736933  93 ARANTQNHGKvIRESRGDLRRSIENVEAAISVAytlAKGEYQQEIakgVDEVLIREPLGVFAVVSPYNFPVMIP-FWFIP 171 Candidatus Kora...
Feature 1                   #  #                              #                ####  #           
1T90_A       164 MAIALGNTFILKPSErtPLLTEKLVELFEKa-GLPKGVFNVVYGAHDvVNGILEHPeIKAISFVGSKPVGEYVYKKGSen 242 Bacillus subtilis
YP_357913    173 LAIACGNTVVLKSASlvPMTSMRLLELLIEa-GLPKGVVNLITCSRNeLTDLLSHPdIRGISFVGSTPVGLKIYQAGAas 251 Pelobacter carb...
ZP_02443510  166 LAIATGNTVVLKAASftPLTSMRIMELFYEegGFPKGVVNLVTCSRNeSEVLLTDPrVKAVTFVGTTEVGKHIYSIAAah 245 Anaerotruncus c...
YP_065651    164 ICMVTGNTMVLKAASyvPRTAMRLMELWQEa-GLPPGVLNLVTANRTeAEILLRHPeIKGVSFVGSTTVGRHIYETATan 242 Desulfotalea ps...
ABB84834     182 QALVAGNTFVLKPSEqvPYSAMRLASLFKEa-GLPDGVLNIVNGGREtVEALADHPdIKALGFVGSSRVAKLVYARGAaa 260 uncultured delt...
ZP_01906282  177 QAIVGGNCFVLKPSEqvPLSVVRLAELFAEa-GLPAGVFNVVHGGKAaVEALCDHPdIKAFAFVGSTPVAKLTYGRAAta 255 Plesiocystis pa...
YP_628404    170 IAVTLGNAFILKPSEkvPLTACALGELMCEa-GYPAGVFSVVHGGKEaVDALVAHPdVQAVGFVGSSAVARHLYAEGCkr 248 Myxococcus xant...
NP_968421    168 IALTLGNAYIWKPSEktPLTSMKIAAALQEa-GLPDGLFQVLHGGKDtVEAIIDHPqVKAVGFVGSTKVAQHVYQRGTal 246 Bdellovibrio ba...
NP_342675    174 YAIVLGNTVVVKPSEitPVPMDFIIRIFDEi-KLPRGVVNVVHGAKDvVDEFLTNKlVQGVTFVGSTRVGKYIYENAGkn 252 Sulfolobus solf...
YP_001736933 172 YALALGDTLVVKVSSttPVPMVLVMEALAS--ELPPGVLNVIYSDHKvGEHLVTHPlVEGTAFVGTSNAALRLYELSAsk 249 Candidatus Kora...
Feature 1              ###                               #                                       
1T90_A       243 LKRVQSLTGAKNHTIVLNDaNLEDTVTNIVGAAFGSaGERCMACAVVTVEegiADEFMAKLQEKVADIkignglddgVFL 322 Bacillus subtilis
YP_357913    252 GKRVQALTQAKNHALVLRDaPLDWSARRIINSAFGCaGQRCMALPTVVVEdciADEFVALLKKYAQELtmgpayeetTQL 331 Pelobacter carb...
ZP_02443510  246 GKRVQAQCEAKNHALVLEDcDLESTVNAIINSTYGCaGMRCMALPVVVVQesiADKFVAKLKEKAMAMkvgcaynpeTNL 325 Anaerotruncus c...
YP_065651    243 GKRVQALCAAKNHALVLEDcNLERTAQGIINAFCGCaGARCMALPVIVVQesiADKLVERITYHAKKLtmgkawlpeTGM 322 Desulfotalea ps...
ABB84834     261 SKRVLCLGGAKNHLVLVPDaDLELSAGNITASFVGCaGQRCMAASVLLAVg-eVQPVIDAIAEQARSVvl------gQDM 333 uncultured delt...
ZP_01906282  256 GKPALCLGGAKNHLIVVPDaDLELTAENVVASFTGCsGQRCMAAANLVAVg-eVDHIVAAIAERAAKLvp------gTDH 328 Plesiocystis pa...
YP_628404    249 GKRVLALGSAKNHLIVVPDaDPELTPQAVVDSFTGCaGQRCMAASVLLAVg-nVESLLQEVVRRAAKLel------gPGM 321 Myxococcus xant...
NP_968421    247 GKRVLALGGAKNHIVLLPDaNPDLTGAGISDSFTGCaGQRCMAAAVVLAVg-dVDHHIQKIIQRAQSLvl------gKDM 319 Bdellovibrio ba...
NP_342675    253 GKKAIVQAGAKNFVVVMPDaDLNKAIPSIVSAFFGNaGQRCLAAANLVAVgniYDEVKRKFIEASKQLkigygldesVDM 332 Sulfolobus solf...
YP_001736933 250 GKRFLGGGSAANYAVVMPDaDLERTVHNLRDSKFGNtGQRCLAIQNIVLVgdiYDKFKEQFLNLAKEIrigyglderSEM 329 Candidatus Kora...
Feature 1                                                                       # #              
1T90_A       323 GPVIREDNKKRTLSYIEKGLeeGARLVCDGRENvs-----ddGYFVGPTIFDNVtteMTIWKDEIFAPVLSVIRVKnLKE 397 Bacillus subtilis
YP_357913    332 GPLVSAGQKKFVVDMINKGVeeGAELVLDGREVvveg--ceeGYFVGPTIFDNVkpdMVVGDEEIFGPVVSIKRVKdFEE 409 Pelobacter carb...
ZP_02443510  326 GPVVNEKHKQSICNWIQKGVdeGAELVLDGRDIvvpg--yenGFFVGPTILDHVtdeMSVGTREIFGPVTVIKRVKnFEE 403 Anaerotruncus c...
YP_065651    323 GPIVNAGHKKSILDWIARGIteGADLVLDGRRPvvaa-gcenGYFIGPTIFDNVtpeMSIGSEEIFGPVLSVKRVKdFAE 401 Desulfotalea ps...
ABB84834     334 GAIINPASVARITRYIDEAErmGATVVVDGRGArvp---gapGNWVGPTLIDHCtgeMPASCEEIFGPVLSIRRVAtLDE 410 uncultured delt...
ZP_01906282  329 GAITSASSVERIRGYIDRAEaaGAKVIVDGRAKkgd---eaeGYWMGATVIDGVaadSPAAKEEIFGPVLSIVRVPtLEA 405 Plesiocystis pa...
YP_628404    322 GALIDRGSLDRLETAIARAEaeGARVLLDGRGHkpqgepwsgGNWLGPTLLDGVrpeMEAARRELFGPVLSIVRVPtLSA 401 Myxococcus xant...
NP_968421    320 GAIISKSQVQFLKDAITRAEkeGAKILLDGRNTpapa-gldhGHWIGPTIMDNVapnSEAATLEYFGPVLSIIRCRdITH 398 Bdellovibrio ba...
NP_342675    333 GPVVTKDAKKRIIGYIEKGIeeGAKLLLDGRDVkvpe--ypnGYFLGPTVFDEVtpeMVIAKEEIFGPVASIIHVKnLDE 410 Sulfolobus solf...
YP_001736933 330 GPMASRKYRDNVIKMIEEGLkeGAKLALDGRGVrvee--ypdGFYLGPTVLEGVtpdMKVAREEIFGPVANLLRADsLDQ 407 Candidatus Kora...
Feature 1                   #                                                                    
1T90_A       398 AIEIANKSEFANGACLFTSnSNAIRYFRENIDAGMLGINLGvPAPMAFFPFSGWKSSFfGTLHANgKDSVDFYTRKKVVT 477 Bacillus subtilis
YP_357913    410 GITIMNNNEFANGSSIFTRdGHKSREFARRTDGGMVGINVGiPVPLAFFPFSGHKRSFfGDLHCLgRDGVKFYTQTKTVT 489 Pelobacter carb...
ZP_02443510  404 GLAVMNANPFANGSVIFTQnGYYARQFELLTDGGMVGINVGiPVPSAYFPFSGNKDSFyGDQHVLgLDGVRFYTRAKTVT 483 Anaerotruncus c...
YP_065651    402 GIALMNANPYANGSVIYTEsGFHARNFVAQTDGGMVGINVGiPVPVGIFGFTGQKKSFyGDLHTMgQDGFRFYTEQKTVT 481 Desulfotalea ps...
ABB84834     411 AITIENASPYGNAAAIFTTsGGVARYALERFQAGMCGVNIGvPVPREPFSFGGWNDSKiGHGDMTgFDGFRFWTRARKVT 490 uncultured delt...
ZP_01906282  406 ALELEKSSAYGNASSIYTTsGHVAREVMGRVEAGMCGVNIGvPVPREPFGFGGWNDSKfGHGNITgWDGFRFWTRPRKVT 485 Plesiocystis pa...
YP_628404    402 ALAVENASPYGNAASIFTTnGGVAQTVVEGVRAGMVGVNVGvPVPREPFSFGGTGDSRfGHGDITgPSSLDFWTQVKKVT 481 Myxococcus xant...
NP_968421    399 AMQIENSNPYGNACSVFTSsGSLAEKVIRQASTGMVGVNVGvPVPREPFSFGGANASKfGHGDITgAQSLDFWSNSKKVT 478 Bdellovibrio ba...
NP_342675    411 AINIINRSNYGNASSIFTTsGYYARKFRREVNTGNIGINIGvAAPMAFFPFGGRKESFfGILHGQ-IDSVDFFTDKKVVI 489 Sulfolobus solf...
YP_001736933 408 AIEWINKNKYHHSASIFTRsGKYAREFLHNVYVGNVGINIGiAAPVGWFPFGGKRLAGvGSHHPQ-MDAVDFFTDRKVGI 486 Candidatus Kora...
Feature 1           
1T90_A       478 ARY 480 Bacillus subtilis
YP_357913    490 TKW 492 Pelobacter carbinolicus DSM 2380
ZP_02443510  484 KHW 486 Anaerotruncus colihominis DSM 17241
YP_065651    482 STW 484 Desulfotalea psychrophila LSv54
ABB84834     491 TKW 493 uncultured delta proteobacterium DeepAnt-32C6
ZP_01906282  486 SKW 488 Plesiocystis pacifica SIR-1
YP_628404    482 RKW 484 Myxococcus xanthus DK 1622
NP_968421    479 MKW 481 Bdellovibrio bacteriovorus HD100
NP_342675    490 TRW 492 Sulfolobus solfataricus P2
YP_001736933 487 VRW 489 Candidatus Korarchaeum cryptofilum OPF8

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