1YOW,1YP0,1YMT,1ZDT


Conserved Protein Domain Family
NR_LBD_SF-1

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cd07070: NR_LBD_SF-1 
Click on image for an interactive view with Cn3D
The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132755
View PSSM: cd07070
Aligned: 7 rows
Threshold Bit Score: 420.513
Threshold Setting Gi: 67463977
Created: 10-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingcorepressor
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #  #                                    
1YOW_A         4 VPELMLQLLQLEPDEDQVRARILGCLQEPtksrp-dqpaaFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNC 82  human
1YP0_A         2 VPELILQLLQLEPEEDQVRARIVGCLQEPaksrs-dqpapFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNC 80  house mouse
1YMT_A         8 VPELILQLLQLEPEEDQVRARIVGCLQEPaksrs-dqpapFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNS 86  house mouse
1ZDT_A         3 VPELILQLLQLEPDEDQVRARILGSLQEPtksrp-dqpaaFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNC 81  human
BAA76713     227 IPEVILKLLQLEPDEAQVKARILACLQQEqgkgrheklstFGLMCKMADQTLFSIVEWARSCIFFKELEVGDQMKLLQNC 306 chicken
Q95L87       225 VPELILKLLQLEPDEGQLKARILACLQEPskgrp-drptpFGLMCKMADQTLFSIVEWARSCVVFKELEVADQMKLLQNC 303 tammar wallaby
NP_001091438 229 IPEVILKLLQPEPDEPQVKARILSCLQQEqnkgrheklnmFGLMCKMADQTLFSIVEWARSCIYFKELEVSDQVILLQNC 308 African clawed ...
Feature 1         #  ##  #            # #     #   ##  ###  #      #                              
1YOW_A        83 WSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLaLQLDRQEFVCLKFIILFSLDL 162 human
1YP0_A        81 WSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHaLQLDRQEFVCLKFLILFSLDV 160 house mouse
1YMT_A        87 WSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHaLQLDRQEFVCLKFLILFSLDV 166 house mouse
1ZDT_A        82 WSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLaLQLDRQEFVCLKFIILFSLDL 161 human
BAA76713     307 WSELLVFDHVYRQLQHGKEHSVLLVTGQEVDLSAVAAQAGSILHSLVLRAQELVLHLHsLQVDRQEFVCLKFLILFSLDV 386 chicken
Q95L87       304 WSELLVFDHIYRQIQHGKEGSILLVTGQEVDLSTVAAQAGSLLHSLVLRAQDLVQQLHsLQVDRQEFVCLKFLILFSLDV 383 tammar wallaby
NP_001091438 309 WSELLVFDHIYRQMQHSKENSILLVTGQEIEVSAISSQAGSTLNNLILRAQELVIVLHsLQVDRQEFVCLKFLILFSLDE 388 African clawed ...
Feature 1                                                        #  #  ##  #                   
1YOW_A       163 KFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAK 240 human
1YP0_A       161 KFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAK 238 house mouse
1YMT_A       167 KFLNNHSLVKDAQEKANAALLDYTLSHYPHSGDKFQQLLLSLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAK 244 house mouse
1ZDT_A       162 KFLNNHILVKDAQEKANAALLDYTLCHYPHSGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAK 239 human
BAA76713     387 KYLENHALAKDAQEKANAALLEYTVCHYPHCTDKFRQLLLRLTEVRALSMQAEEYLYHKHLSGEVPCNNLLIEMLHAK 464 chicken
Q95L87       384 KFLENHGLAKDAQEKANSALLEYTMCHYPHCGDKFRQLLLRLAEVRSLSMQAEEYLYHKHLGGEVPCNNLLIEMLHAK 461 tammar wallaby
NP_001091438 389 KFLENHSLAKSAQEKVSSALLEYTMCHYPHCTDKYRMLLVRLAEIRSISMQAEEYLYHKHLSGEVPCNNLLIEMLHAK 466 African clawed frog

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