1YOW: human Steroidogenic Factor 1 LBD with bound Co-factor Peptide

Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism. Mouse LRH-1 is believed to be a ligand-independent transcription factor with a large and empty hydrophobic pocket. Here we present structural and biochemical data for three other NR5A members-mouse and human SF-1 and human LRH-1-which reveal that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity. Evolutionary analysis of structure-function relationships across the SF-1/LRH-1 subfamily indicates that ligand binding is the ancestral state of NR5A receptors and was uniquely diminished or altered in the rodent LRH-1 lineage. We propose that phospholipids regulate gene expression by directly binding to NR5A nuclear receptors.
PDB ID: 1YOWDownload
MMDB ID: 33428
PDB Deposition Date: 2005/1/28
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 1YOW: dimeric; determined by author and by software (PISA)
Molecular Components in 1YOW
Label Count Molecule
Proteins (2 molecules)
Steroidogenic Factor 1(Gene symbol: NR5A1)
Molecule annotation
Tif2 Peptide
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB