Conserved Protein Domain Family
RNAP_I_III_AC19

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cd07029: RNAP_I_III_AC19 
AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
The eukaryotic AC19 subunit of RNA polymerase (RNAP) I and RNAP III is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei: RNAP I, RNAP II, and RNAP III. RNAP I is responsible for the synthesis of ribosomal RNA precursor, while RNAP III functions in the synthesis of 5S and tRNA. The AC19 subunit is the equivalent of the RPB11 subunit of RNAP II. The RPB11 subunit heterodimerizes with the RPB3 subunit, and together with RPB10 and RPB12, anchors the two largest subunits, RPB1 and RPB2, and stabilizes their association. The homology of AC19 to RPB11 suggests a similar function. The AC19 subunit is likely to associate with the RPB3 counterpart, AC40, to form a heterodimer, which stabilizes the association of the two largest subunits of RNAP I and RNAP III.
Statistics
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PSSM-Id: 132907
View PSSM: cd07029
Aligned: 36 rows
Threshold Bit Score: 86.1318
Threshold Setting Gi: 162605670
Created: 16-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:AC19 - AC40 heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the multi-subunit complexes of yeast RNAP II and archaeal RNAP
  • Comment:The AC19/AC40 heterodimer of eukaryotic RNAP I and III is equivalent to the RPB11/RPB3 and L/D heterodimers of yeast RNAP II and archaeal RNAP, respectively.
  • Comment:The yeast RNAP II RPB11/RPB3 heterodimer (L/D heterodimer in archaea), together with RPB10 (N) and RPB12 (P), anchors the two largest subunits, RPB1 (A'/A") and RPB2 (B), stabilizing their association.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #    ### #    #             #                                     
Q5XK67        14 VQAQGNEESCVTFVLHEEDHTLGNSLRYMVMKNPEVEFCGYSITHPSETKINFRIQTRn------------gIPAVEPFR 81  African clawed ...
CAJ43896      37 LQRHADSESAATVTFSHEDHTLGNPLRHVIMEDPSVTSAGYAIPHPLEAKMQLHVQSS--------------EYAVETVA 102 Trypanosoma bru...
XP_002140426  23 EMLKNLESANLTFQINGEDHTLGNIMRHLAMLNPSTTFAGYAIPHPSISSMNLRIETVsnvdygkedqifklEDKFDDTK 102 Cryptosporidium...
XP_001713350   5 KLKIKFVNNVTKITFYNESNTLGNLLQYFMKFNGLIDVCGYYIPHPSENLLKFFYSTKy------------qVNNYLLNL 72  Guillardia theta
XP_001712558   5 IINIKKTQKVILISFYNEDHTLGNILRTVIEGNPNIDYVGYNIPHPSENIMNLKISSSk-------------FDSLEPFI 71  Hemiselmis ande...
NP_180514      2 EHGSFTNVSHASFTLSEEDHTLANAVRFVLNQDPRVTVAAYTIPHPSLEQVNIRVQTTg-------------DPAREVFK 68  thale cress
XP_001703168   1 MEGEATDFFAATFSIEEEDHTLANSLRFFLNKNPHVAFCGYSMPHPSEELVNLRVQTT--------------GAARGAVK 66  Chlamydomonas r...
CAQ42812       6 YYEHMRTLTHATFCFENEDHTLGNCLRCILLQKEGVEFAGYTVPHPTQAEINLRIQTTg-------------EPAVNILK 72  Plasmodium know...
EEA98146      27 HEQEACKASQLTFTLTGEDHTLGNTIRSILVRKPGVEFAGYSVPHPTQPEMNIRLQTTg-------------ESAMQLLR 93  Toxoplasma gond...
XP_953135      1 MDKVDHKSPNITFCIENEDHTLGNTLRALLVERDDVVFAGYSVPHPMEPEMNIRIQTTg-------------QPAVEVFL 67  Theileria annul...
Feature 1          ##    ### ###  
Q5XK67        82 RGLNELVDVCQHVLNTF 98  African clawed frog
CAJ43896     103 KGLERLAAICDETLKKF 119 Trypanosoma brucei brucei
XP_002140426 103 KTKQDIIIHSNNSINNL 119 Cryptosporidium muris RN66
XP_001713350  73 WLFNTIYIFFFIILSIF 89  Guillardia theta
XP_001712558  72 LGLKNSGELFVLFGNFF 88  Hemiselmis andersenii
NP_180514     69 DACQELMQMNRHVRSVF 85  thale cress
XP_001703168  67 AACEDVSQVCGHMRSTL 83  Chlamydomonas reinhardtii
CAQ42812      73 DALDDLSNICDIMLNKF 89  Plasmodium knowlesi strain H
EEA98146      94 ESFDDLASICDHLDTLY 110 Toxoplasma gondii ME49
XP_953135     68 DCLDDMVKICDILREKF 84  Theileria annulata strain Ankara

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