Conserved Protein Domain Family
NR_LBD_DHR4_like
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cd06953: NR_LBD_DHR4_like 
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
The ligand binding domain of Ecdysone-induced receptor DHR4: Ecdysone-induced orphan receptor DHR4 is a member of the nuclear receptor family. DHR4 is expressed during the early Drosophila larval development and is induced by ecdysone. DHR4 coordinates growth and maturation in Drosophila by mediating endocrine response to the attainment of proper body size during larval development. Mutations in DHR4 result in shorter larval development which translates into smaller and lighter flies. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, DHR4 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Links
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Statistics
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PSSM-Id: 132751
Aligned: 9 rows
Threshold Bit Score: 261.542
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         ##   #                                 #   #  # 
XP_001235478  351 QLVSAEDLEPLgtpmlied--gykvtqaeLFALLCRLADELLFRQIAWIKKLPFFcELSIKDYTCLLSSTWQELILLSSL 428  chicken
P70033        211 QLLTAEDIEPLntpmlied--gykvtqseLFALLCRLADELLFRQITWVKKLPFFcDLSIKDYTCLLSTTWQELILLSSI 288  African clawe...
Q9W539       1256 QTLIDCDAMEDiatlphfs--efledkseISEKLCNIGDSIVHKLVSWTKKLPFYlEIPVEIHTKLLTDKWHEILILTTA 1333 fruit fly
Q15406        256 QLLSAEDLEPLgtpmlied--gyavtqaeLFALLCRLADELLFRQIAWIKKLPFFcELSIKDYTCLLSSTWQELILLSSL 333  human
Q4V8R7        222 QILADEDLTPLttpmlied--gysvtqseLLALLCGIADELLFRQIVWLKRLPFFtDLSIKDCTRLLGSSWHQLILLSSI 299  zebrafish
Q4H3F3        350 QLVLAEDASFLvsigpdhgfndvtiskdqLFSILCKVADEMLYRQIVWIKKLPFFeTISIKDHTTLLSTTWAEIILLAAL 429  Ciona intesti...
Q4U1Y2        454 VLKVAEKEGVNlkehrysdl-patmelddFRRLQCRLGEELVFHLVQWVKHLPFFtQLSAVEHTHLLKTKWLDLMLLCTI 532  Strongylocent...
XP_001200128  388 ALIVAEPIEPLtlpfevat--nqqvgyagLFELLCKLMDRMLHHQIQWTKRLPFQsKIPISDSTSLLTTCLIELLLLEVM 465  purple urchin
Q9U2R6        222 ELVEMDCLDRLinlkglrinpsancdiapACKRLTRIGDEIVEQLVEWTKTLPFFdELPVEAHTHLLTQRWAELVLLSAG 301  nematode

Feature 1                                                                         #               
XP_001235478  429 TVYsk----------------------------------------------------qIFGDLADVtskYSPSddelhrf 456  chicken
P70033        289 TTYsk----------------------------------------------------qIFGDLTDVtskYSPSedelhrf 316  African clawe...
Q9W539       1334 AYQalhgkrrgegggsrhgspastplstptgtplstpipspaqplhkddpefvsevnsHLSTLQTClttLMGQpiameql 1413 fruit fly
Q15406        334 TVYsk----------------------------------------------------qIFGELADVtakYSPSdeelhrf 361  human
Q4V8R7        300 TVHsa----------------------------------------------------qILGELANVthhYTPSshtlqrf 327  zebrafish
Q4H3F3        430 CVHed----------------------------------------------------qLFGDLADItskYLPDndelsrf 457  Ciona intesti...
Q4U1Y2        533 SRAmhfkqplvnssvssgmsg-------------------kssggmdvglsfeqcthkNLLLLQECmnkTLDLrldmdvf 593  Strongylocent...
XP_001200128  466 RTQpl----------------------------------------------------eLFTKLGQIldtYIPSedelrkf 493  purple urchin
Q9U2R6        302 YYAcsvftpdspdttem---------------------------idetdeisftnpqvNLRLLQNRlslVLGKeiplehv 354  nematode

Feature 1                #                                                                        
XP_001235478  457 seegmevMERLIYLFRKFnqLKVSNEEYACMKAINFLNqdir---gltnASQLEQLNKRYWYVCQDFteyky-------- 525  chicken
P70033        317 sedgmevMERLIYLFRKFsqLKVSNEEYVCMKAINFLNqdiq---gissASQVEQLNKRYWYVCQDFteyry-------- 385  African clawe...
Q9W539       1414 kldvghmVDKMTQITIMFrrIKLKMEEYVCLKVYILLNk----------EVELESIQERYVQVLRSYlqnssp------- 1476 fruit fly
Q15406        362 sdegmevIERLIYLYHKFhqLKVSNEEYACMKAINFLNqdir---gltsASQLEQLNKRYWYICQDFteyky-------- 430  human
Q4V8R7        328 gedamevMESLNFLFRKFhqLNISNEEYSCLKTITLLNqett---glcnTSMLKQLSERYWTLCRELterlh-------- 396  zebrafish
Q4H3F3        458 tdyemeiLERVTYLYQKFshLKIDREEYVIMKVINFLNqdik---glqeVERVEEINKRYWYACQRYtelramernagrs 534  Ciona intesti...
Q4U1Y2        594 rdemgevVEKVTKLAASFrtLGVTRNEYLLLKVILFLDqtg-----kpfSEQIRSVQEPYILALKDFmean--------- 659  Strongylocent...
XP_001200128  494 gqngleiIDVATNALARYraLKVSVQEHVCLKVICFLNpenp---nltkLPVIKDLSKQYYYVLHDHvqlnn-------- 562  purple urchin
Q9U2R6        355 akeagplVTRFTTLLHSFsnLKVSPEAYVCIKAITLLHlsadstldrsiIDKVNTLQDHFVKTLQIHlhqpge------- 427  nematode

Feature 1                                                      
XP_001235478  526 -------phqpnRFPDLMMCLPEIRYIagkmvnvPLEQLPLLFKA 563  chicken
P70033        386 -------phqpnRFPDLMMCLPEVRYIagklvnvPLEQLPLLFKA 423  African clawed frog
Q9W539       1477 -------qnpqaRLSELLSHIPEIQAAaslllesKMFYVPFVLNS 1514 fruit fly
Q15406        431 -------thqpnRFPDLMMCLPEIRYIagkmvnvPLEQLPLLFKV 468  human
Q4V8R7        397 -------pqrpkRFSDIITCLTEIRHTsgkmmsiPLEQLPLLFKA 434  zebrafish
Q4H3F3        535 dassnaaasgasRFRDLMLCLPEIRYVagkmlntDVTKLPLLFKA 579  Ciona intestinalis
Q4U1Y2        660 --------nqpgRFDDFLSQLPELHASsklllhsKLLYMPYLLNA 696  Strongylocentrotus purpuratus
XP_001200128  563 -------niaaeRFRELLILIPQIRHLalkcnaiSFDNAPLLFKA 600  purple urchin
Q9U2R6        428 -------daqttSLAQILDWLPDLRNAssvllhsKMFYVPFLLCK 465  nematode

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