2OFQ


Conserved Protein Domain Family
VirB9_CagX_TrbG

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cd06911: VirB9_CagX_TrbG 
Click on image for an interactive view with Cn3D
VirB9/CagX/TrbG, a component of the type IV secretion system.
VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.
Statistics
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PSSM-Id: 132874
View PSSM: cd06911
Aligned: 137 rows
Threshold Bit Score: 52.5838
Threshold Setting Gi: 161986690
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
VirB7
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:VirB7 interaction site
Evidence:
  • Structure:2OFQ: NMR structure of a complex between the C-terminal domain of VirB9 and a VirB7 interaction domain as exemplified by the homologs TraO and TraN from plasmid pKM101, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #######              ######                                                
2OFQ_A         1 AGAKNYQYVMSEqp-------eMRSIQPVHVWDNYRFTRFEFPa---------nAELPQVYMISas----gkETLPNSHV 60  IncN plasmid R46
YP_998429    174 DASQLAFYSVRTd---------NTQYQRMHVYSDGVKTWMRLPpg--------vQDLPAVFMVDkdqrgreqLMPVNYTV 236 Verminephrobact...
YP_551997     31 VGQYDFTYFTSG----------EQRATPVQVFDDGKSTYFQFRa---------gEAIPAIFNNKdg-----kVSLLVPYF 86  Polaromonas sp....
ZP_02008233   36 NQNYDFAYQTSG----------GTGVRPSQVFDDGTKTYFQFPi---------gKFAPVIELDEgg-----rRKLLEPMQ 91  Ralstonia picke...
YP_001595649 176 EALRKYRYHIYTrykydegkafVGNNTISDVYDDGRFTYIRLAnp--------nRGVLSVETMIggk---naIAPVKYDD 244 Vibrio sp. 23023
YP_515936     28 GDAFDFGYRSAG----------ENDLKPVQAFDDGERTYLQMKg----------ALVPVVLASVd-------GKMTMLQV 80  Rhodoferax ferr...
YP_552206     27 MDRFNFDYAVQG----------DSRAKPLQVFDDGQRTYLQYRa---------sDDIPAFISTRt-------AQLLIPRQ 80  Polaromonas sp....
ZP_01865373  133 VPPDTGQYRLRG----------DRAVRPAAISDDGTKTYLIWGe---------eQAMPAVFAIGps----gkEEMVEGYM 189 Erythrobacter s...
YP_973263    185 PISPNNLVFFRVe--------gNKEYERMHAYDDGRMTFIRMPpg--------iQDLPALFLVDtd----nkLVPINYTV 244 Polaromonas nap...
YP_001812241  25 TDPFDFDYEIMG----------GIAERPALIFNDGAKTYIQPRagqvitadgghNEGPYVVVDGt-------PQTISYKV 87  Burkholderia am...
Feature 1                                #             #######   
2OFQ_A        61 VGen-------rNIIEVETvaKEWRIRLG---------DKVVGVRNNN 92  IncN plasmid R46
YP_998429    237 ADrenl---rdrDVIIIDRtaALWMLRIG---------QSIEVRVARD 272 Verminephrobacter eiseniae EF01-2
YP_551997     87 EG----------PYIRVQEtsGRFTLQLG---------RAQAQVVYGG 115 Polaromonas sp. JS666
ZP_02008233   92 EG----------LYYTVPLigNRFVLQRG---------QETAVVEYDG 120 Ralstonia pickettii 12D
YP_001595649 245 AY----------GMYRITGiyPKFTLRVD---------DVKIIVTRSD 273 Vibrio sp. 23023
YP_515936     81 KNn--------gQYLVVPAitNKLTLQFA---------NLSAKVTYTG 111 Rhodoferax ferrireducens T118
YP_552206     81 EG----------PYTVLNGtpGDFVAQLG---------ASSARITHSS 109 Polaromonas sp. JS666
ZP_01865373  190 RG----------GVYTIDRvyAELVFRID---------KEKARAKRRR 218 Erythrobacter sp. SD-21
YP_973263    245 LDrkgh---ddrDVLKVERtnPKWLLKIK---------KSVEVKLTKE 280 Polaromonas naphthalenivorans CJ2
YP_001812241  88 AGraatarwkkaNTFIGGTg-TLAALHDDqpagfdgftNRLTIIGTRG 134 Burkholderia ambifaria MC40-6

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