2CR0,1WFI


Conserved Protein Domain Family
p23_mNUDC_like

?
cd06492: p23_mNUDC_like 
Click on image for an interactive view with Cn3D
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation.
Statistics
?
PSSM-Id: 107241
View PSSM: cd06492
Aligned: 17 rows
Threshold Bit Score: 147.487
Threshold Setting Gi: 114052643
Created: 29-Jun-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2CR0_A        20 YRWTQTLaELDLAVPFRVsfrlKGKDVVVDIQRRHLRVGLKGQPPVVDGELYNEVKVEeSSWLIEdgKVVTVHLEKINKM 99  house mouse
ABF18532     167 YTWTQTLqELELRVPFDVkftlKAKDVVVNIQRKSLKVGLKGHPPVIDGELHADVKMEeSLWHLDk-NTVVVTLDKINQM 245 yellow fever mo...
NP_648923    173 YTWTQTLeEVELKIPFNLtfglRARDLVISIGKKSLKVGIKGQTPIIDGELCGEVKTEeSVWVLQdsKTVMITLDKINKM 252 fruit fly
NP_001040262 169 YKWTQTLeEVEIRVPLRQi--lRPRDLTVVINKKHLKVGIKGQPLIIDGELDADVKIEeSTWVLQdgRNLLINLEKVNKM 246 domestic silkworm
NP_499749    161 YQWTQTLqELEVKIPIAAgfaiKSRDVVVKIEKTSVSVGLKNQAPIVDGKLPHAIKVEnCNWVIEngKAIVLTLEKINDM 240 nematode
XP_391855    176 YRWTQTLqDLEIKVPLKVnfsaRPKDVSVTITKKRLTCGIKGQPPIIDGDFPHEVKVEeSTWVIEdgKVLLLNLEKVNKM 255 honey bee
XP_001638773 157 YKWTQTLeEIELRIPLDVsfkpKGKDVVVDIQQKHLKAGLKGHPPIIDGDFPKKVKLEeCTWLIDg-KNLVLNLEKVNKM 235 starlet sea ane...
AAP06040     170 YSWYQTLsEVDIKIPTRLphriKCRDVYVEIARRHIKIGLKNQEPILCGKLYNEVKVEeSSWTLLdgLVISVNLEKINKM 249 Schistosoma jap...
EDV25170     162 YKWTQTLsDVELRVPFKVsfpvKGKDVICEIKPNHLKIGLKGHEPIIDGDLHKTIKIEnCYWVIEdkKAVMVTIEKVNKM 241 Trichoplax adha...
XP_001945094 165 YRWTQTLsDIELKIPSKAafklRPRDVIVNLKKKHIFVGIKGQPPILDDELQHEIKLEeTTWLLEdgKTFLINIEKVNKM 244 pea aphid
2CR0_A       100 EWWNRLV 106 house mouse
ABF18532     246 NWWDRLV 252 yellow fever mosquito
NP_648923    253 NWWSRLV 259 fruit fly
NP_001040262 247 NWWGRLV 253 domestic silkworm
NP_499749    241 EWWNRFL 247 nematode
XP_391855    256 QWWAHVV 262 honey bee
XP_001638773 236 EWWSQLV 242 starlet sea anemone
AAP06040     250 EWWPRIC 256 Schistosoma japonicum
EDV25170     242 EWWPRLV 248 Trichoplax adhaerens
XP_001945094 245 EWWSKLV 251 pea aphid
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap