1RL1,1WH0


Conserved Protein Domain Family
p23_CS_SGT1_like

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cd06466: p23_CS_SGT1_like 
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p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.
Statistics
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PSSM-Id: 107223
View PSSM: cd06466
Aligned: 91 rows
Threshold Bit Score: 60.2931
Threshold Setting Gi: 123892457
Created: 29-Jun-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RL1_A        13 DWYQTesQVVITLMIKNvq-knDVNVEFSe--kELSALVKlp-sgEDYNLKLELLHPIIPe--qSTFKVLsTKIEIKLKK 86  human
AAF18435     224 DWFSSngFVTINVYCRGal-peTANIVSDg--hTVRVSMKhgfgnASVDLDYDLWDEVIPe--eSRVVIGeRKVEISLKQ 298 Caenorhabditis ...
Q28CZ9       173 DWFQTesLVTVAVYTKMkn-vcSELVIVDhlenVLRGEIIig--dYSYLLHSELSHPVQKdi-eVKVSATaGKIEIKMKK 248 western clawed ...
XP_001618515  72 DWYQNdrIVTIAVYTRAkdiqmDSIILELkdqkDLNAIFIlg--eKSYQLHLDLEEKVSNq--qVRIANDtGKVDLLLTK 147 starlet sea ane...
NP_001018496 179 DWFQTdgTVNIVVYTKRki-psAGCAVVDlqddNLRVEMLlg--rMSYLLYWRLSSRVQDhv-dVQTAHSvGKVQLCLRK 254 zebrafish
EDV25029     209 DWYQSdkSITIVVYTKHkgltnEDILVNVknnrKTDIWIVlg--dKILQLCLDLFEEICEs--eVKISTE-GNIEVILLK 283 Trichoplax adha...
XP_001360344 192 DWIQQrsELTLFFYTRSfs-npGLIVRRKdp-qQLVARVFle--sRWHTFDLQLAGKVEWppkaVRVGTEtGKIELVLAK 267 Drosophila pseu...
AAY54856     191 DWIQQrsELTLIFYTRSla-npGLVVRRKdl-qQLSVRVLvq--hNWHSFDFQLTNNVEWppklAKIGSEtGKIELVFVK 266 fruit fly
XP_001868287 157 DWIQKtaEVSFIFYTRAlc-npAVIVELVnn-lEFNVRFFle-gnVLHRYRFQASNNLQWpc-tVRQSLEtGKVEIVFNK 232 southern house ...
XP_309336    150 DWIQKtaELTLIFYTRSla-npGVMVECVdh-lEVTVNILle-ssVQHRYRFHLANNVRWpc-tVRTSLEsGKIELMFNK 225 Anopheles gambi...
1RL1_A        87 pea--vrWEKLE 96  human
AAF18435     299 khg--tgWPRLK 308 Caenorhabditis elegans
Q28CZ9       249 kep--vsWKSLG 258 western clawed frog
XP_001618515 148 depesqfWECTL 159 starlet sea anemone
NP_001018496 255 svk--ekWTQLG 264 zebrafish
EDV25029     284 qei-gkkWLSLG 294 Trichoplax adhaerens
XP_001360344 268 eep--apWSSYG 277 Drosophila pseudoobscura
AAY54856     267 eea--epWPTYG 276 fruit fly
XP_001868287 233 llp--glWTNYG 242 southern house mosquito
XP_309336    226 lcp--alWTSYG 235 Anopheles gambiae str. PEST
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