Conserved Protein Domain Family
DPM1_like

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cd06442: DPM1_like 
DPM1_like represents putative enzymes similar to eukaryotic DPM1.
Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.
Statistics
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PSSM-Id: 133062
View PSSM: cd06442
Aligned: 66 rows
Threshold Bit Score: 214.319
Threshold Setting Gi: 52222857
Created: 4-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Ligand bindingDXD motifPutative
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #                                                                          
O60762       29 VLLPTYNERENLPLIVWLLVksfse--sginyEIIIIDDGSpDGTRDVAEqlekiygsdr--illrprekkLGLGTAYIH 104 human
NP_142068     5 IIVPTYNERDNLEELFSRISsalk----gydyEIIIVDDDSpDKTWEKAMelsklypv-----kvirrvneKGLSSAVIR 75  Pyrococcus horik...
AAL63560      4 VVVPTYNEAENLAELVQRLDgalr-----egyEIIIVDDNSpDGTAEVARglasrypv-----kvivrerrGGLSSAVVE 73  Pyrobaculum aero...
NP_147219    13 VIVPTLNERDNIRPLYVGLKkslega-glecfEIVFVDDSStDGTIEEVErlsrsdprv----rlivrrgeKGLSRAVLE 87  Aeropyrum pernix K1
XP_651399     6 IIVPTYNEAENIEQLIIQLEdtlk----dinfDILVMDDNSpDKTGEKVQrlkseghkc----dvvirtenRGLSPAVIE 77  Entamoeba histol...
CAA90875      7 IIVPAYKECGNLSHLQAGVDrladdgfsknevEMVIVDDNSrDGSVEVVEkvrnegygv----rievrtndRGLSSAVIH 82  Trypanosoma bruc...
P14020        7 VIVPAYHEKLNIKPLTTRLFagmspe-makktELIFVDDNSqDGSVEEVDalahqgynv----riivrtneRGLSSAVLK 81  baker's yeast
YP_711837    82 VVVPTRNEAHNIEPLLRRLDdalr----glagEVIFVDDSD-DGTPEAIArvrptvslpvrvhhraprarvGGLGGAVSE 156 Frankia alni ACN14a
ZP_01853906   6 IIVPTYCEAENLTVLIPRVNrvlte--aeldaEIIVVDDDSpDETIQVCEklaencpl-----rlitrkneRGLSTAVIA 78  Planctomyces mar...
YP_462933     8 IIVPTYKEAKNITPLSEQIDramkd--anltyEIIVVDDDSkDGIIEAIEkikdryni-----elkvrkseKGLSSAVIS 80  Syntrophus acidi...
Feature 1                      #                                                                
O60762      105 GMKHAtgnyIIIMDADLSHHPKFIpefirkqkegnfDIVSGTRykgnggv-ygwdlkRKIISRGANfltqil---lrpga 180 human
NP_142068    76 GFSEAsgdvFVVMDADLQHPPEVIpsllre-iekgnDIAIASRyvkggkv-enwpfyRRLISRGAIiigrlal-pkiagi 152 Pyrococcus horik...
AAL63560     74 GARAAsgriVVVMDADLQHPPEIVpalvr--eaergCLAIASRyikggmv-vgwplaRKIVSRGAVmlarlll-peargv 149 Pyrobaculum aero...
NP_147219    88 GLRRArgrvAVVMDADLQHPPETVpllvekvaggeaDLAVASRyapggrv-egwslvRRIISRGAVllawlli-pesrrt 165 Aeropyrum pernix K1
XP_651399    78 GFGIAkgnvVLVMDADLQHPVSVVpklyea-ikngaEVAVGSRhcpgggi-enwafhRRVISWGAAllarp-----ftsv 150 Entamoeba histol...
CAA90875     83 GISVSkgsfILVMDADLQHPPKTVpcllralekpgvEFVCGTRygagveidkdwplhRRFISWGARllarp-----ltpl 157 Trypanosoma bruc...
P14020       82 GFYEAkgqyLVCMDADLQHPPETVpklfe--slhdhAFTLGTRyapgvgidkdwpmyRRVISSTARmmarp-----ltia 154 baker's yeast
YP_711837   157 GFALCaapyAVIIDGDLQHPPETIpallaaalheaaDVVIGSRyvsggsasglagttRHLVSTGSNllcrlafprrlrgv 236 Frankia alni ACN14a
ZP_01853906  79 GLNAAsggiLLVMDADLSHPPEKIpelvsalnqrqaDFVIGSRyveggttdqswgwfRKWNSRVATwlsrp-----ftsa 153 Planctomyces mar...
YP_462933    81 GFGLVtgevVVIMDADLSHPPAKIpelvapildgscDFMIGSRfvkggsa-hhfnwyRKLNAWLSKmiarp-----ftrv 154 Syntrophus acidi...
Feature 1                                                                                       
O60762      181 SDLTGSFRLYRKEVlekli-ekcvsKGYVFQMEMIVRArqln---ytigEVPISFVDRVYGESKLGGNEIVSFLKGLLTL 256 human
NP_142068   153 KDPVSGFFALKRSVvegv---klnpIGFKILMEILIKGkys-----rvtEVPFTFSTRKFGESKLKGKTMVNYLRHVYRL 224 Pyrococcus horik...
AAL63560    150 KDPVSGFFAYSRDCiagv----kptGLYKILLDVLAQCkpa-----civEVPFVFGRRTRGRSKLGRRHIFDFLRQLLVL 220 Pyrobaculum aero...
NP_147219   166 RDPVSGFFAVNLERvrpa---ivsgRGFKILLEILYTNpya-----rvvDVPFTFRGRSRGSSKLGPSTILDYLLQVLQL 237 Aeropyrum pernix K1
XP_651399   151 SDPMSGFFAVKSSIlkrs---kleaKGYKILLEVLVKTgak-----nvvEVPIIFTTRVHGESKLTGGVMTNYLLHLFSL 222 Entamoeba histol...
CAA90875    158 SDPMSGFFGPSRSMffnggrevvnpIGYKIALELFVKCavr-----kyeEVGFNFAARTVGESKLTGKVIINYLEHLKLL 232 Trypanosoma bruc...
P14020      155 SDPMSGFFGLQKKYlencnprdinsQGFKIALELLAKLplprdprvaigEVPFTFGVRTEGESKLSGKVIIQYLQQLKEL 234 baker's yeast
YP_711837   237 SDVMSGFFLVRVAAvdra---glrpDGYKILLELLATAgpl-----rirEVGYAFAERHAGASNASMSEGGRFVRRLFSL 308 Frankia alni ACN14a
ZP_01853906 154 RDPLAGFFAIKRQTylkah-qilnpVGYKIGLELIVKCrcr-----nvvEIPIEFTDRVAGSSKLSFKEQLRYLKHLKRL 227 Planctomyces mar...
YP_462933   155 SDPMAGFFAFPGKMlnplp--alnpLGFKIGLEMIVKAspk-----risEVPIQFQERLFGESKLSLKEQIYYLIHITRL 227 Syntrophus acidi...

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