1WLJ


Conserved Protein Domain Family
REX4_like

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cd06144: REX4_like 
Click on image for an interactive view with Cn3D
DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
This subfamily is composed of RNA exonuclease 4 (REX4 or Rex4p), XPMC2, Interferon (IFN) Stimulated Gene product of 20 kDa (ISG20), and similar proteins. REX4 is involved in pre-rRNA processing. It controls the ratio between the two forms of 5.8S rRNA in yeast. XPMC2 is a Xenopus gene which was identified through its ability to correct a mitotic defect in fission yeast. The human homolog of XPMC2 (hPMC2) may be involved in angiotensin II-induced adrenal cell cycle progression and cell proliferation. ISG20 is an IFN-induced antiviral exonuclease with a strong preference for single-stranded RNA and minor activity towards single-stranded DNA. These proteins are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. REX proteins function in the processing and maturation of many RNA species, similar to the function of Escherchia coli RNase T.
Statistics
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PSSM-Id: 99847
View PSSM: cd06144
Aligned: 46 rows
Threshold Bit Score: 196.968
Threshold Setting Gi: 145487332
Created: 28-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #### #                                          #   #                        
1WLJ_A         8 VAMDCEMVGLGph-----reSGLARCSLVNVHGAVLYDKFIRP-EGEITDYRTRVSGVTPQHMVGATPFA--VARLEILQ 79  human
XP_001873159   9 LAISCANVGVGpgg----ttSMLARVSIVNYRGSTVFDHYVAPtMQVVTDYRSVTTGISESDLYSADAWAfnVVQQYVAN 84  Laccaria bicolo...
XP_001388371  10 ISIDCEMVGCGeng----hiSVLGRIAVVDDKLKLLMDAFVKP-SMRVTNFRTKWSGLTWDKLKYGESFE--SIQKKFLQ 82  Cryptosporidium...
XP_001418958 106 VALDCEFVGVGeag----ekHACARVCVVGSSGEILLHTWVNP-GEEVTDYREELTGATPEKLADAPSLE--RVRAIVVQ 178 Ostreococcus lu...
AAA74917       9 VAISSVSVGVGprg----etDMLARVAVIDFTGAVLLDVYVAP-TNPVRDYREAKTGIKPEYLYSSRAQDirAVYQTVRQ 83  Schizophyllum c...
EDQ68158     121 VALDCEMVGGGsdg----siNICARVCLVDEDENVLLNTYVQP-LLPVTDYRYEITGIKPSDFNGAPSFK--RVRYIVKR 193 Physcomitrella ...
XP_001416483   5 LALDCEMVGVGegg----veSMLAQVCVINEYGNTVYLSYSRA-YKTVTDYRTHVSGILPRHVEGSSAREfaDVKRDVAE 79  Ostreococcus lu...
XP_001697385   1 LALDCEMVGTGpng----svSALARVCLVNGAGAVLLDTFVRP-NEPVTDYRTWVSGVRPEDVARGRPYD--EVVQQVGD 73  Chlamydomonas r...
EDQ88131     109 YALDCEMVTVRgkgg--amkSALGRISIINATGQVVIDEFVRP-QQPIVSYNTRWSGIRKRDLVDATPFP--KVRDRLRT 183 Monosiga brevic...
XP_001008163 432 VAIDCEMVQCEasqkdgfptQELARVSIVNYNGHVLLDTYVRP-QKKIKNYLTKVSGITFTHIKNAPTYP--EVKNKIFE 508 Tetrahymena the...
Feature 1                              ## ###                                                    
1WLJ_A        80 LLKG-------------KLVVGHDLKHDFQALK-EDMSG--YTIYDTSTDRLLWREakld---------------hcrRV 128 human
XP_001873159  85 LIKG-------------KVLVGHGIWNDLSVLG-IPHPA--VSTRDVALYQPFRNAlrs----------------phqII 132 Laccaria bicolo...
XP_001388371  83 IVEHyrke-----stsgLVFVGHDISNDFQVLK-WTPPE--SEIRDTCTYFPLRKLliksllekgeithhqkegflrqKP 154 Cryptosporidium...
XP_001418958 179 ILLGkavqtrrehvgvkHLLIGHSVEHDLEVLD-IKWKK--GMRRDTAQFPLYLRHth-------------------lPF 236 Ostreococcus lu...
AAA74917      84 VLRN-------------KVVVGHSMWLDFMVLG-LTHPT--KDTRDVALYLPFRNTlrc-----------------qrMI 130 Schizophyllum c...
EDQ68158     194 ILEDg------------PLLIGHDLRHDLACLR-LDHSP--ELIRDTATYQLFVKTsg-------------------vSH 239 Physcomitrella ...
XP_001416483  80 LIKG-------------RIVVGHALENDFSALQ-LHHPR--EDTRDTAKWRPLLRPphf-----------------rkPR 126 Ostreococcus lu...
XP_001697385  74 MVRG-------------RVLVGHAIGHDLKALRlEDHPR--THLRDTSKWPGLMKTlpng---------------rkvSA 123 Chlamydomonas r...
EDQ88131     184 ILKN-------------ARVVGHAVSNDFRAMN-LTSKElnALVYDTSASSTLKIAalge--------------ndgnAV 235 Monosiga brevic...
XP_001008163 509 ILKD-------------KIIVGHSVQHDLSSIK-FEPPKd-KMIRDISNYKELKQSg--------------------kKV 553 Tetrahymena the...
Feature 1                            #    #         
1WLJ_A       129 SLRVLSERLLHKSIQnslLGHSSVEDARATMELYQ 163 human
XP_001873159 133 GLQTLAWQLLCRRCQe--GQLHPLENARVALDLYR 165 Laccaria bicolor S238N-H82
XP_001388371 155 SLRSLSKHVLNLNIQq--GSHCPWEDAKSTMMLYL 187 Cryptosporidium parvum Iowa II
XP_001418958 237 KLRALAEQFLGEKIQeegEAHDPCVDARISMRLYQ 271 Ostreococcus lucimarinus CCE9901
AAA74917     131 GLWTLNYRLLGLRCSa--APVDPLESARVALNLYR 163 Schizophyllum commune
EDQ68158     240 KLRFLTEVFLGYKIQd-gTIHDPCEDAIAAMRLYK 273 Physcomitrella patens subsp. patens
XP_001416483 127 RLRHLARDFCALSIQc-gDAHDPAEDALAALAIYR 160 Ostreococcus lucimarinus CCE9901
XP_001697385 124 SLKDLAATHLGLAIQq--GEHTPVDDARAALYLYQ 156 Chlamydomonas reinhardtii
EDQ88131     236 SLKRLSKYLLHRTIQe--KQHCSLIDARVTLELYQ 268 Monosiga brevicollis MX1
XP_001008163 554 SLKKMVKQELGITFQe--GSHDSISDARAALLIYK 586 Tetrahymena thermophila SB210

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