Conserved Protein Domain Family
PAN2_exo

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cd06143: PAN2_exo 
DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
PAN2 is the catalytic subunit of poly(A) nuclease (PAN), a Pab1p-dependent 3'-5' exoribonuclease which plays an important role in the posttranscriptional maturation of pre-mRNAs. PAN catalyzes the deadenylation of poly(A) tails, which are initially synthesized to default lengths of 70 to 90, to mRNA-specific lengths of 55 to 71. Pab1p and PAN also play a role in the export and decay of mRNA. PAN2 contains a DEDDh-type DnaQ-like 3'-5' exonuclease domain with three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis.
Statistics
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PSSM-Id: 99846
View PSSM: cd06143
Aligned: 23 rows
Threshold Bit Score: 254.463
Threshold Setting Gi: 1730942
Created: 28-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #### #                                                                       
Q5F450        970 VGLDAEFVTLNeee-------------------------aeLRSDGTKSTIkp---------sqMSVARITCVRgq---- 1011 chicken
XP_001466838  846 IAIDAEYVVLKw----------------------------aSRDEGNEMFYvsqr------kphMGLARVSCILss---- 887  Leishmania in...
Q5KHY2        916 VAIDAEFVALQqee-------------------------meFRSDGTKNILrp---------shMSLARVSVLRge---- 957  Filobasidiell...
P53015        909 VGLDAEFIKIKtd---------------------------lLEFDGKTVQM-------------RAVGRASCVDs----- 943  nematode
Q09798        887 VGIDSEFVALQqee-------------------------teVRSDGTKSTIkp---------skLSLARVSVLRge---- 928  Schizosacchar...
XP_667048    1704 VALDSEYVALDveq-------------------------svVRSDGTKEILkk---------sqLSLARVSIVRcgkisl 1749 Cryptosporidi...
P53010        907 VAIDAEFVSLQsel-------------------------ceIDHQGIRSIIrp---------krTALARISIIRgee--- 949  baker's yeast
XP_001611623   86 VALDVEGVKTGvetlegsryrklpdafssprtmtmnresfvYSADETEEQElstlaryvskhvpRLLNRVSAVRgc---- 161  Babesia bovis...
XP_952261     939 FALDIEYVKTDlknt-----------------------pvnDSSNEKSSFIvnede----nnylYSLARVTAIRand--- 988  Theileria ann...
A5DAD0        894 IAIDAEFVVSEpeq-------------------------leIRYTGTRKLIkp---------kkLTLARVSVLRgn---- 935  Pichia guilli...
Feature 1                                          #   #                                      ## #
Q5F450       1012 --------gpNEGVPFIDDYIST---QEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDVGVKFVGHGLQ 1080 chicken
XP_001466838  888 --------kdGDERTIVDDYVHI---PEEIEDYVTQYSGIHPGDLDPLESSKSLTSLKSTYLKLRALVDGGVVFVGHGLA 956  Leishmania in...
Q5KHY2        958 --------geMEGKPFIDDYIHT---SEAVVDYLTEFSGIKAGDLDPNNSPHTLVPLKVAYKKLRLLVDLGCIFVGHGLS 1026 Filobasidiell...
P53015        944 ---------tGERIIFDDHVKLTd--DVEVVDYLTKFSGIVKADLCPTTSEKYLTTHKRLLLRMHVLIQRGVTFVGHALH 1012 nematode
Q09798        929 --------gpNKGLPFIDDYVAT---DDKVTDYLTEYSGIHPGDLDPDRSPYNVVPLKVAYKKLRLLVNAGCIFVGHGLQ 997  Schizosacchar...
XP_667048    1750 tgandnveidNKKGLIMDHYVSYgsnSQQPRDYLTKYSGVRPGDLDPKTSSHFLTSKSCILKKLQFLVDAGVVFIGHALP 1829 Cryptosporidi...
P53010        950 --------geLYGVPFVDDYVVN---TNHIEDYLTRYSGILPGDLDPEKSTKRLVRRNVVYRKVWLLMQLGCVFVGHGLN 1018 baker's yeast
XP_001611623  162 --------geAFGIPFLDHYIHR---REPPKDYLTRFSGIHQGDLDLKSSLHWLTTRKSIYMKIRYLVDAGCKILGHGLE 230  Babesia bovis...
XP_952261     989 --------dnLHGVPFLDHYILN---NKPPKDYNTRFSGIRSGDLELKSSLHWLTTHKLIYLKLRYLIDNGCKVIGHGLE 1057 Theileria ann...
A5DAD0        936 --------gpNIGVPFIDDYIVW---TGHIEDYLTSFSGIEPGDLDPEVSKKALVTLQTVYRKLWLLLNMGCVFVGHGLQ 1004 Pichia guilli...
Feature 1         ##                                               #    #         
Q5F450       1081 KDFRVINLMVPKDQVIDTVYLFHIPRKr-mISLRFLAWYFLDLKIQgETHDSIEDARTALQLYR 1143 chicken
XP_001466838  957 QDFRVCNIVVPRKQIIDTLEIFHKPGSr-yLSLRFLAYHVLGESVQeDEHDSIEDARTSLRLYR 1019 Leishmania infantum JPCM5
Q5KHY2       1027 KDFRTINIFVPPEQVMDTVLIYTLPGSqrkLSLRFLAWYLLHQDIQtNSHDSIEDAHFALLLCK 1090 Filobasidiella neoformans
P53015       1013 NDFTVLNVHVAESQIIDTVTLMRLGTQr-mLSLQFLVKEILGETIQmEAHDSVVDARYALKLYR 1075 nematode
Q09798        998 KDFRIINLLVPPEQVVDTVDLFFLSSRqrkLSLKFLAWYLLDEEIQlTEHDSIEDALTALKLYD 1061 Schizosaccharomyces pombe
XP_667048    1830 SDFKIINIYVPPFQIIDTVEIYRLPDEr-yISLKFLAKFVLNKNIQtEVHDSIVDAKTALELFL 1892 Cryptosporidium hominis TU502
P53010       1019 NDFKHININVPRNQIRDTAIYFLQGKRy--LSLRYLAYVLLGMNIQeGNHDSIEDAHTALILYK 1080 baker's yeast
XP_001611623  231 QDFKMLNIVVPKSQVIDTVELYRLPGRr-yISLQFLAAHILNIRIQdGEHDSIEDAKAALYLYR 293  Babesia bovis T2Bo
XP_952261    1058 QDLRILNICVPSGCVIDTLELFWIPGKr-yMSLQFLSYHILNQKIQvSEHNSIEDAKTSLHLYK 1120 Theileria annulata strain Ankara
A5DAD0       1005 NDFRCINLVVPKTQVRDTADLFYLPEFkrkLSLKFLAYVLLKEKVQtGNHDSVEDAYTALMLFQ 1068 Pichia guilliermondii

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