Conserved Protein Domain Family
Ig4_PDGFR

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cd05859: Ig4_PDGFR 
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR)
The members here are composed of the fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR; also known as cluster of differentiation (CD) 140a) alpha and beta. PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFR alpha binds to all three PDGFs, whereas the PDGFR beta binds only to PDGF-B. PDGF alpha is organized as an extracellular component having five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFR alpha and PDGFR beta are essential for normal development.
Statistics
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PSSM-Id: 409445
View PSSM: cd05859
Aligned: 5 rows
Threshold Bit Score: 167.733
Threshold Setting Gi: 82071582
Created: 11-Jan-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
129892     313 GFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLi-eNLTEITtdvekiqEIRYRSKLKLIRAKEEDSGH 391  human
129895     316 GFIDLEPMFGSEEFANLHEVKSFIVNLHAYPTPGLFWLKDNRTLs-eNLTEITtsivttkETRFQSKLKLIRAKEEDSGL 394  African clawed frog
NP_990080  313 GFIHLEPQFSPLEAVNLHEVKNFVVDVQAYPAPKMYWLKDNVTLi-eNLTEIVtssnrvqETRFQSVLKLIRAKEEDSGT 391  chicken
129890     314 GYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLgdsSAGEIAlstrnvsETRYVSELTLVRVKVAEAGH 393  human
P79749     316 GFVAVKSTRKQNITAELQENVELRVEIEAYPPPQIRWKKDGAPVr-gDKTIIIrq---ehEIRYVTILTLVRVRTEQKGL 391  torafugu
129892     392 YTIVAQNEDAVKSYTFELLTQV 413  human
129895     395 YTLVAQNDRETKSYSFILQIKV 416  African clawed frog
NP_990080  392 ILWLLKNEDEIKRYTFSLLIQV 413  chicken
129890     394 YTMRAFHEDAEVQLSFQLQINV 415  human
P79749     392 YTALITNEDDVKEVTFALEVQV 413  torafugu
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