1CS6,2OM5


Conserved Protein Domain Family
Ig2_Contactin-2-like

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cd05727: Ig2_Contactin-2-like 
Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
The members here are composed of the second Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (also called TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.
Statistics
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PSSM-Id: 409392
View PSSM: cd05727
Aligned: 5 rows
Threshold Bit Score: 156.573
Threshold Setting Gi: 20152017
Created: 26-Jun-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:domain-domain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6; Gallus gallus axonin-1 Ig2 and Ig3 interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Anoxin-1 domains Ig2 and Ig3 interact with each other, helping to form the U-shaped axonin structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #                              #  # #                               
1CS6_A        107 ERDPVKITegwGVMFTCSPPPHYPa-LSYRWLLNEFPNFIPADGRRFVSQttGNLYIAKTEASDLGNYSCFATSHidfIT 185  chicken
2OM5_A        106 ERDPVKAHegwGVMLPCNPPAHYPg-LSYRWLLNEFPNFIPTDGRHFVSQttGNLYIARTNASDLGNYSCLATSHmdfST 184  human
116918        142 ERPEVKVKegkGMVLLCDPPYHFPddLSYRWLLNEFPVFITMDKRRFVSQtnGNLYIANVESSDRGNYSCFVSSPs--IT 219  house mouse
NP_001079338  126 ERYEVKVKegtGAVLICDPPPHVPddLNYRWLLNEFPVFLSPDNRRFVTQtnGNLYIAKVEHLDRGNYSCFVSSPs--VT 203  African clawe...
AAM11368      120 RSAETSEMn-wGKSIFCDPPQHYPd-VRYYWARDYFPNFVEEDQRVFVSRd-GALYFSFIETVDRANYSCTVQTLv--SD 194  fruit fly
Feature 1                    
1CS6_A        186 KSVFSKFSQLS 196  chicken
2OM5_A        185 KSVFSKFAQLN 195  human
116918        220 KSVFSKFIPLI 230  house mouse
NP_001079338  204 KSVFSKFISLL 214  African clawed frog
AAM11368      195 TGRNGPFFPLR 205  fruit fly

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