Conserved Protein Domain Family
STKc_MAST

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cd05609: STKc_MAST 
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270760
Aligned: 20 rows
Threshold Bit Score: 523.892
Created: 4-Aug-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #            # #                               #               ##
Q6P0Q8        511 DFETIKLISNGAYGAVFLVRHKsTRQRFAMKKINKQNLIlRNQIQQAFVERDILTFAeNPFVVSMFCSFDTKRHLCMVME 590  human
CAB05684      552 DFDTIRLVSNGAYGAVYLVRHReTRQRFALKKMNKQTLMlRNQVDQVFAERDILTMAdNPFVVSFYGSFETRQYLCMLME 631  nematode
NP_648778     834 DFDIVKLISNGAYGAVYLVKHKtTRQRFAMKKINKNNLIlRNQVEQVFAERDILSFAdNPFVVSMYCSFETKKHLCLVME 913  fruit fly
XP_001634586  287 DFDYIKLISNGAFGAVYLVRHKeTHTRFAIKKINKHAMLhKNQVEQVFAERDILTFAeNPFVVGLWCCFETKKHLCMVME 366  starlet sea a...
AAH79780      398 DFETIKLISNGAYGAVYLVRHKeTRQRFAMKKINKQNLIlRNQIHQVFVERDILTFAeNPFVVSMFCSFETRRHLCMVME 477  African clawe...
XP_794804     576 DFENIKIISNGAYGAVYLVRHKaSLQRFAMKKICKQNIAlRNQREQVFAERDILTFAeNPFVVALYCSFETKKYLCMVME 655  purple sea ur...
EEC18046      308 DFETIKLISNGAYGAVYLVRHReSRQRFAMKKINKQNLVlRNQVEQVFAERDIMSFTdNPFVVSMLCSFETKRHLCLVME 387  black-legged ...
EEN62946      776 DFETVKLISNGAYGAVYLVRHKeTKQRYALKKINKQNLMlRNQIQQAFTERDILTFAeNPFVVTMYCSFETKKHLCMVLE 855  Florida lancelet
EFX76338      385 DYEVVKLISNGAYGAVYLVRHReTRQRFAMKKINKRNLLlRNQIEQAFAERDILCFTdNPFVVSLQCSFETQRHLCMVME 464  common water ...
EKC18680      224 DFEIIKLISNGAYAAVYLVRHKeSRQRFAMKKICKQNLIlRNQTEQVFTERDILSFTeNPFVVSMYCSFETKRHLCMVME 303  Pacific oyster
Feature 1          #   # #                                    # # ## #         ##  #              
Q6P0Q8        591 YVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE 670  human
CAB05684      632 YVEGGDCAALLKSAGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAE 711  nematode
NP_648778     914 YVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYE 993  fruit fly
XP_001634586  367 YVEGGDCASLLKNIGALPADLARMYFAETVLAVEYLHSYGIVHRDIKPDNLLITSLGHIKLTDFGLSKIGLMNSTTRMYE 446  starlet sea a...
AAH79780      478 YVEGGDCATLLKNMGPLPVDMSRMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKVGLMNMTTNLYE 557  African clawe...
XP_794804     656 YVEGGDVATLIKHIGPLPLETARLYFAEAVLAIEYLHSYGIVHRDIKPDNMLITSTGHIKLTDFGLSKIGIMSLTTNLYE 735  purple sea ur...
EEC18046      388 YVEGGDTATLLKNMGPLPVDIAQFYFAETVLAVEYLHSYGIVHRDLKPDNLLITNMGHIKLTDFGLSKVGLMNLATNLYE 467  black-legged ...
EEN62946      856 YVEGGDCATLLKNMGPLPVDMARMYFAETVLAVEYIHSYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYE 935  Florida lancelet
EFX76338      465 YVEGGDCATLLKNMGPFPCDMARLYFAEMVLAVEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKMGLMSLATNLYE 544  common water ...
EKC18680      304 YVEGGDCATLVHKGGPLPFDLARMYFAETVLALEYLHSYGVVHRDLKPDNLLITATGHIKLTDFGLSKIGLMSLTTNLYE 383  Pacific oyster
Feature 1                        ######                          #     #  #                       
Q6P0Q8        671 Ghi-ekDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDE 749  human
CAB05684      712 GydavvETQQFQDKQLCGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPEEDE 791  nematode
NP_648778     994 Gyi-dsETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSED 1072 fruit fly
XP_001634586  447 Hsl-drDTKQFMDKQVFGTPDYLAPEVILRQGYGRAVDWWSMGIILYEFLMGVPPFYGDTPEELFAHTLSGDIEGLDGED 525  starlet sea a...
AAH79780      558 Ghi-ekDTREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDIIWPGGEE 636  African clawe...
XP_794804     736 Gni-drDTKQFQDQQVCGTPQYIAPEVILRQGYGKPVDWWSMGVVLYEILVGCPPFFGETPEELFAQTINVMIEWPDGDD 814  purple sea ur...
EEC18046      468 Gyl-dkETKQFNDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLVGCVPFFGDTPEELFAHVISDEVDWPDEDE 546  black-legged ...
EEN62946      936 Dt---lDPKQFTDKQVCGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLVGCVPFFGETPEELFSQAVNDEIVWPEGEE 1012 Florida lancelet
EFX76338      545 Gfi-drETREFSDKQVFGTPEYIAPEVVLRQGYGKPVDWWSSGIILYEFLIGCVPFFGETPEELFSHVVNDDIEWPSESD 623  common water ...
EKC18680      384 Gsl-eqDCTEFSDKQVIGTPEYIAPEVILRKGYGKPVDWWSMGIILYEFLVGCPPFFGNSPEELFSQVINEDIEWPEEEE 462  Pacific oyster
Feature 1                                                    
Q6P0Q8        750 a-LPPDAQDLTSKLLHQnPLERLGTg-SAYEVKQHPFFTGLDW 790  human
CAB05684      792 a-LPPEAADLCRRLLEKnPAERLGTlnGAAQLMAHEFFILLDF 833  nematode
NP_648778    1073 wpVQAEAKDIISQLLQQnPRDRLGTqsGALEMKEHEYFLGMDW 1115 fruit fly
XP_001634586  526 a-PPDDAVDLIRGLLEQdPTQRLGSa-GALEVKEHVFFTGLDW 566  starlet sea anemone
AAH79780      637 a-LPADSQDLITRLLRQnSLERLGTg-GAQEVKQHTFFLSLDW 677  African clawed frog
XP_794804     815 a-LSDEAMELINGFLQQdPLFRLGTg-GSEDVKGHRFFQGVDW 855  purple sea urchin
EEC18046      547 wpLPDEARLLVTQLLQQnPLDRLGTa-GAQEVREHPFFRDVDW 588  black-legged tick
EEN62946     1013 a-PPDDAKDLITRLLEQnPVERLGTt-GAYELKEHEFFADLDW 1053 Florida lancelet
EFX76338      624 wpVPVEAKDLITALLQQnPRDRLGTa-GGAEVKSHPFFDRLDW 665  common water flea
EKC18680      463 wiVRDDARDLITQLLQHnPINRLGTg-GAQEVKDHIFFMDLDW 504  Pacific oyster

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