1VKR,1VRV


Conserved Protein Domain Family
PTS_IIB_mannitol

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cd05567: PTS_IIB_mannitol 
Click on image for an interactive view with Cn3D
PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIA, IIB, and IIC domains are expressed from the mtlA gene as a single protein, also known as the mannitol PTS permease, the mtl transporter, or MtlA. MtlA is only functional as a dimer with the dimer contacts occuring between the IIC domains. MtlA takes up exogenous mannitol releasing the phosphate ester into the cytoplasm in preparation for oxidation to fructose-6-phosphate by the NAD-dependent mannitol-P dehydrogenase (MtlD). The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include mannitol, chitobiose/lichenan, ascorbate, lactose, galactitol, fructose, and a sensory system with similarity to the bacterial bgl system.
Statistics
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PSSM-Id: 99909
View PSSM: cd05567
Aligned: 27 rows
Threshold Bit Score: 88.7822
Threshold Setting Gi: 15829222
Created: 2-May-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site residues are contained within a P-loop structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #########                                                                  
1VKR_A        14 RKIIVACDAGMGSSAMGAGVLRKKIQDAGLsqISVTNSAINNLp---PDVDLVITHRDLTERamrqvPQAQHISLTNFLD 90  Escherichia col...
EDP22187     371 RKIVFACDAGMGSSAMGATKFHNRIKAERPd-LTVTNSSVDTIp---ADADVVVCQRVLADRaakcaPQAQLVTLDNFLA 446 Faecalibacteriu...
NP_357950    498 DAVVVAYGKAQGTATMGCETIRAIFRNKNIr-IPVSTAKISELgefnSKNIMIVTTISLQAEvqqaaPNSQFLIVDSLVT 576 Streptococcus p...
NP_784052    524 EIVFVHHDGHLGTATMATSLMKDRVKKANKh-VSVKNLGIDELa--dNNSLLVVSSAEAAKNlktryTQVQVLITDDLLS 600 Lactobacillus p...
NP_814195    370 QQILFVCDAGMGSSAMGASLLSRQLKAVNLe-MPVTYQSVHQMk--wQPKTLVVIQAELKQLaqkyvPEKDMVSVQNFLE 446 Enterococcus fa...
NP_814199    499 NEILLVHDDRVGSATMGMKVLEEILDKEKIs-MPIRKININELt--qQTQALIVTKAELTEQarkkaPKATHLSVKSMVN 575 Enterococcus fa...
YP_060289    497 DEVVFAYGENKGSATMGQATLVEIFKNRDVg-IPVSKVENHQLvafnSKNILVVTNIANQSVaqqfaPQAQLLVVDSLVT 575 Streptococcus p...
ZP_00603354  497 KEILLVHDDRSGSATMGMTVLKDILDKNHLt-IPLRKVNIQDLk--dEPDSLIVAKESLAEKvqmaaPQSIHLSVNSMVN 573 Enterococcus fa...
ZP_00603359  368 HSVIFACDSGMGSSAMGAALLKKKLAAEKId-LSVGYSSIYELn--nQVNQLVIVQHELAGLarekvPQSQIYVLDHFLE 444 Enterococcus fa...
YP_001088849 385 KKIVFACDAGMGSSAMGASRFKNRIKNLDLn-IEITNSSVDNLp---DDTQIVVTHNTLVERvaknnSSVEIVSINNFLN 460 Clostridium dif...
Feature 1                   
1VKR_A        91 SGLYTSLTERL 101 Escherichia coli O157:H7
EDP22187     447 DPHLDALYNAL 457 Faecalibacterium prausnitzii M21/2
NP_357950    577 TPEYDKMAARM 587 Streptococcus pneumoniae R6
NP_784052    601 SPKYDKMVSEL 611 Lactobacillus plantarum WCFS1
NP_814195    447 IKSYYPQVLAK 457 Enterococcus faecalis V583
NP_814199    576 PQKYETVVSLL 586 Enterococcus faecalis V583
YP_060289    576 TPEYDKMIDRM 586 Streptococcus pyogenes MGAS10394
ZP_00603354  574 PQKYESIAQYL 584 Enterococcus faecium DO
ZP_00603359  445 TDILLSRIKEA 455 Enterococcus faecium DO
YP_001088849 461 DPNLDALFKRL 471 Clostridium difficile 630

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