Conserved Protein Domain Family
Peptidases_S8_Tripeptidyl_Aminopeptidase_II

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cd04857: Peptidases_S8_Tripeptidyl_Aminopeptidase_II 
Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
Tripeptidyl aminopeptidases II are member of the peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Tripeptidyl aminopeptidase II removes tripeptides from the free N terminus of oligopeptides as well as having endoproteolytic activity. Some tripeptidyl aminopeptidases have been shown to cleave tripeptides and small peptides, e.g. angiotensin II and glucagon, while others are believed to be involved in MHC I processing.
Statistics
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PSSM-Id: 173796
View PSSM: cd04857
Aligned: 21 rows
Threshold Bit Score: 646.264
Threshold Setting Gi: 164662515
Created: 30-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #                                                 
Q9V6K1        101 ALVPKAETGVLnflqkYPEYDGRDVTIAIFDSGVDPratgletlcdgktvkVIERYDCSGCGDVDmkkkvtpdengnikg 180  fruit fly
Q09541         63 LLLNKTDTEQEifltkYPNYDGRDILIAILDTGVDPslpgmqv-tttgerkMFDVIDCSGAGDVDtsitrtvkdgvieg- 140  nematode
XP_756664     127 GLLPKDTTEALsflrkYPDFDGRNVRVAILDTGVDPaaigl-----nvpgkVVDVIDCTGAGDIPlqpiepvantgdsss 201  Ustilago mayd...
XP_001750537   19 KLIPKDETGVTdflraRPDYDGRGIRVAILDTGVDPgavnlqv-tstgarkIVDLIDATGSGAVDtatvvqlnedgtlkg 97   Monosiga brev...
XP_001695941   86 HAMPKHEIGALrflqdHPEYDGRGVKICIFDTGVDPgaaglqi-ttdgkpkIIDIIDCTGSGDVDtsrvekadvdgcia- 163  Chlamydomonas...
XP_001751904   25 GLMPKKGIEAIqfleeHPEYDGRGITVAIFDSGVDPaaaglqv-ttdgkpkVIDVLDCTGSGDVDtstivtadedgfit- 102  Physcomitrell...
EEC08850       13 ALLPKKETCIPaflgkYPDYDGRGIKIAILDSGVDPgapglrv-tsdgkpkVIDLMDATGAGDVDtstvveaqdgeivg- 90   black-legged ...
XP_002179315   15 DLVPKKETNVRrfleaYPEYDGRNVIVGILDTGVDPgahglgtlpdgttpkLLNVVDCTGSGDVDvstqvelqrhvnada 94   Phaeodactylum...
XP_001732379   18 GLLPKQATNSRsr-qrFPDYDGRNVRVAVLDTGVDPaalgl-----dgpnkVVDIIDCSGAGDVPlqqveaqartddsai 91   Malassezia gl...
NP_594951      71 GVVPKHETQAYeflkkFPEYDGRGVTVGILDTGVDPgapglsv-tttglpkFKNIVDCTGAGDVDtsvevaaadsndylt 149  Schizosacchar...
Feature 1                                                                                         
Q9V6K1        181 l---------sgnslklspelmalntDPEKAVRVGLKSFSDllpskvrnnivaqaklkhwdkphktatanasrkiv---- 247  fruit fly
Q09541        141 -------------isgrklaipekwkCPTGQYHVGLKPIFElytkgvksrviserkedvvgpshniaasealkq------ 201  nematode
XP_756664     202 khi-----efkspftgriirlssklsNPKGEWKIGFKKAYDlwpgelksrrsaerqkaflvshqallckaqselnalesp 276  Ustilago mayd...
XP_001750537   98 ------------asgtvytnvpdamrSRDGSYRAGSFYLHNlytgglrkrmeawrrkdwdknhgqllanarn-------- 157  Monosiga brev...
XP_001695941  164 ------------gasgrklrlnpdwkNPTGEWRVGCKHVYGlvsrglvsrlkeerkrkweetqrgaiaeavaalakwvsf 231  Chlamydomonas...
XP_001751904  103 ------------gasgarlqinkewiNPTGEWRVGSKLAFSlftgtlinrlkgerkkkwdekqrealtealrql------ 164  Physcomitrell...
EEC08850       91 -------------ltgrklkipdswtNPTGKYHVGVKCAYEmypkslkervqksykerewspphnlalakaar------- 150  black-legged ...
XP_002179315   95 ddgsdgnvhdangndtavddtptpltTPLPQVRLGVKRAYElfpaklrervqetrrqafqaqldryvvdvrqql------ 168  Phaeodactylum...
XP_001732379   92 le-------lespttkrkllvdaawpNPSGVWKVGTKRAYDlwptglverrtkerkkafdvshaallqraldelas---- 160  Malassezia gl...
NP_594951     150 i----------tgrsgrtlklskewkNPSKKWKVGCKLAYEffpkdlrkrlqkletedmnksnrkllqdatdey------ 213  Schizosacchar...
Feature 1                                                                                         
Q9V6K1        248 ----------------------------efesqnpgeasklpwdkkilkenldfelemlnsyEKVYGDIKTSYDCILFPT 299  fruit fly
Q09541        202 -----------------------------ltehekvvggtsektsdkwaredfackvdflksMASVADVGPVADVVTWHD 252  nematode
XP_756664     277 -----------------------asskasdaissnadhnivkdnaklqkdeikariqtlkdlAASYKDDGPLIEAIVFHN 333  Ustilago mayd...
XP_001750537  158 -------------------------------alrkalavdakdqdrahleelqgrvkaletlQTSYEDKGPLYDCFVFKS 206  Monosiga brev...
XP_001695941  232 sggkgktqtmgpraagprssrgqearfdkdtpasklgsdpeakkeraelegrvaalkargdlAKSYEDPGPLIDAVVWHD 311  Chlamydomonas...
XP_001751904  165 ------------------------------tefdkkhlkptepalkkaredlqnrvdfiqkqSDSYEDNGPVIDAVVWHD 214  Physcomitrell...
EEC08850      151 ------------------------------klqqfeaghsaapvkklekeeletqvellgalEKKFEDLGPVYDCVVFHD 200  black-legged ...
XP_002179315  169 ------------------------------aawnvahpkpptspeeakvrddlqarldvlldSEWNDDPGPLYDCVVFYD 218  Phaeodactylum...
XP_001732379  161 ---------------------------erastpsstsdakdrdaaaqrceelqarvsvlkdmHKAWKDPGPVLEAVVFHD 213  Malassezia gl...
NP_594951     214 -----------------------------akfkdkfpeapldkdnlqtqkelearieclkqlAEKFDNPGPLYDVVVFHD 264  Schizosacchar...
Feature 1                                                                                         
Q9V6K1        300 ADGWLTIVDTteqgdldqa-----------------------lrigeysrTHETRNVDDFLSISVNVHDEGNVLEVVGmS 356  fruit fly
Q09541        253 GEMWRVCIDTsfrgrlglgn---------------------vlgtfretgDYAYLTNKDSVVYTVRVSPDGNLTEIVVpS 311  nematode
XP_756664     334 GKHWYAVVGGgegqthdpstgqpedvlkpleqqtldlttvdpitdfrterQWQSFGEQDLLTYTVNIEDNGNLLSLVTvA 413  Ustilago mayd...
XP_001750537  207 NEDEQWRAAVtcteepsliaa-------------------kvmrnynvayEYAAFGEQDCFNYCFNIAEDGNVLTIVTdS 267  Monosiga brev...
XP_001695941  312 GAAWRAALDTsalhpagsgagal--------------aaftpltnyadehKYGTFSELDACNFVLNILDGGRTLSVVVdC 377  Chlamydomonas...
XP_001751904  215 GNLWRAALDTqdmeeesglgkla---------------dctpltnyrmerKYGVFTRMDACTYVLNIFDDGNVLSIVTdC 279  Physcomitrell...
EEC08850      201 GNLWRAVVDTsekgdlesct---------------------llgtyretlEFATLSKEDSLNYAVNIHDDGNLLEIVGnS 259  black-legged ...
XP_002179315  219 GTDYQAVVDVhetgdlrnaq---------------------pftsfaksrQFGTLGTIDQMNYAVQFYNQGTILSLVTdA 277  Phaeodactylum...
XP_001732379  214 GMHWRAVVGGaegdvidsskgepesqha----mvldlrekprltdyrlerEWAYFGEMDLLTYSVNIMNDGQLLSIVTlS 289  Malassezia gl...
NP_594951     265 GEHWRVVIDSdqtgdiylhk---------------------pladfnvaqEWSTFGSLDLLSYGVHVYDNGNITSIVAvS 323  Schizosacchar...
Feature 1           #                                                                             
Q9V6K1        357 SPHGTHVSSIASGNh-sSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMELCrdgrrIDVINMSYGEHAn-- 433  fruit fly
Q09541        312 GAHGSHVAGIAAANypdNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELN-----VDIINMSFGEGTh-- 384  nematode
XP_756664     414 GSHGTHVAGIVGARhdeQPELNGVAPGCEIVSMKIGDSRLGSMEQGQAMLRSAQALIDTK-----CDIANLSYGEDGafg 488  Ustilago mayd...
XP_001750537  268 GSHGTHVAGIVAAFdpeNPERHGVAPGAEIVGIKIGDGRLDAMETGTGLIRGVLAAVRTG-----CQVINLSFGEATs-- 340  Monosiga brev...
XP_001695941  378 GAHGTHVAGITAAHfpdDPGSNGIAPGAQIISCKIGDTRLGSMETGTGVVRGLIAARQHG-----AHLINMSYGEPTt-- 450  Chlamydomonas...
XP_001751904  280 SPHGTHVAGITAAHhpeEPLLNGVAPGAQIVSCKIGDTRLGSMEMGTGLVRALIAVVETK-----CDLINMSYGEPTs-- 352  Physcomitrell...
EEC08850      260 STHGTHVASIAAACfpdRPERNGVAPGAQLVSIGIGDIRLGSMETGTALVRAVVKLLETG-----CHVINMSYGEHAh-- 332  black-legged ...
XP_002179315  278 SPHGTHVAGITAAA---EGERSGVAPGAQLVSFKIGDSRLGSMETGTSLTRAMIEAVRHK-----CDVINLSYGEGCa-- 347  Phaeodactylum...
XP_001732379  290 GTHGTHVAGIIGAQt-qDPATDGVAPGTEIVSLRIGDARLGSMEQGQALLRAAQALIDTR-----CDVANMSYGEDGafg 363  Malassezia gl...
NP_594951     324 GTHGTHVAGIIGANhpeTPELNGAAPGCQLVSLMIGDGRLDSLETSHAFSRACSEIIKNE-----VDIINISFGEDAg-- 396  Schizosacchar...
Feature 1                                                                                         
Q9V6K1        434 wSNSGRIGELMNEVVNK-YGVVWVASAGNHGPALCTVGtPPDISQPSLIGVGAYVSPQ-MMEAEYAMREKl-PGNVYTWT 510  fruit fly
Q09541        385 lPDVGRVIEEARRLINR-RGVIYVCSAGNQGPALSTVG-APGGTTTGVIGIGAYLTSE-SADTLYGVYKPv-ESSIYPWS 460  nematode
XP_756664     489 aEDKGAFAKALRDIVIRqRDILFVSSAGNNGPALTTVG-QPGGTTSSVLSVGAYVNAGaMQKAEYALVEKgvPDSVTTWC 567  Ustilago mayd...
XP_001750537  341 vINAGRIVKVMQEAVRK-HNVTFISSASNSGPALCTLG-CPGGVSDHLIGVGAYVSKA-MITPLYSAHDDv-NENPYTWS 416  Monosiga brev...
XP_001695941  451 tPNAGRFIELATELVRK-HGVIFVASAGNAGPALTTVG-APGGTSSALFGVGAYVSPQ-LAAAGHSVLEApaEGLQYNWS 527  Chlamydomonas...
XP_001751904  353 mPNYGRFIQLAEEVVNK-HGVIFVSSAGNNGPSLTTVG-APGGTSSSILSVGAYVTPS-MAASAHSLVETptEGVQYTWS 429  Physcomitrell...
EEC08850      333 -WLGGRLLELLHEVVDK-HGVIMVNSAGNHGPALSTVNaPGTMPSSSIIAVGAYVSPE-MMLVEYSLREKm-PGLGYTWT 408  black-legged ...
XP_002179315  348 mPNHGRFVELAEELVWK-HNVVFVSSAGNNGPAISTVG-APGGTSSACIGVSAYVSPA-MMKAGYSMPYH--TGTTYTWS 422  Phaeodactylum...
XP_001732379  364 vEDKGAFAHALHQVIRE-HGVCFVSSAGNNGPALTTVG-QPGGTTSGVLSVGAYVTAGdMQQAEYALVERgvPSNVTTWC 441  Malassezia gl...
NP_594951     397 iPNKGRVIELLRDELAGkRNVVIVSSAGNNGPAYTTVG-APGGTTFDVISVGAYVTSG-MMQAQYNLLSTv-HDTPYTWC 473  Schizosacchar...
Feature 1                                                          #                              
Q9V6K1        511 SRDPCIDGGQGVTVCAPGGAIASVPQFTM-----------SKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIK 579  fruit fly
Q09541        461 SRGPCQDGKLGVSLVAPAAAFAGVPQYCR-----------QSMQMMNGTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVR 529  nematode
XP_756664     568 SRGPTADGDRGVSIYAPGAAITSIPRYCL-----------QSTQLMNGTSMSSPNACGSIALLLSGLKAQKVPITPARVF 636  Ustilago mayd...
XP_001750537  417 SRGPAPNGTLGISICAPGGAITNVPLWNL-----------YSNQLMNGTSMSSPNTAGCVAVLLSGLLAEGRRWTPSAVR 485  Monosiga brev...
XP_001695941  528 SRGPTSDGHTGVAFSAPGGAIAPVPQWTQqvtsiragvagPRRQLMNGTSMSSPNACGGIALLLSGLLATGGALAPHRLR 607  Chlamydomonas...
XP_001751904  430 SRGPTADGDIGVTLSALGGAVAPVPKWTL-----------QPRMLMNGTSMSSPCACGGIALVLSALKAEGRKISPHVVR 498  Physcomitrell...
EEC08850      409 SRGPSPDGGLGVSVCAPGGAITSVANWTL-----------RGSQLLNGTSMSSPHVAGAIALLLSGLKAQGLPYSPYSVR 477  black-legged ...
XP_002179315  423 SVGPTADGDNGVDVTAPGGAITSVSNWCL-----------QKSMLMNGTSMSSPHATGCVALLISACKAEGIPVSPARIR 491  Phaeodactylum...
XP_001732379  442 SRGPTADGAAGVSIYAPGAAITSICRYAL-----------QSTQLMNGTSMSSPNAAGAVALLVGACKPEGITPTPFRIF 510  Malassezia gl...
NP_594951     474 SRGPTLDGDTGVSIYAPGGAITSVPPYSL-----------QNSQLMNGTSMSSPSACGGISLILSALKAQKKPYTAAAIK 542  Schizosacchar...
Feature 1                   
Q9V6K1        580 RAISVTATKL 589  fruit fly
Q09541        530 MALENTAYML 539  nematode
XP_756664     637 NAVRVTGKDV 646  Ustilago maydis 521
XP_001750537  486 RALENTARPV 495  Monosiga brevicollis MX1
XP_001695941  608 RALENTATPL 617  Chlamydomonas reinhardtii
XP_001751904  499 KALENTAAPV 508  Physcomitrella patens subsp. patens
EEC08850      478 RAMENTALKV 487  black-legged tick
XP_002179315  492 RALQNSAKRL 501  Phaeodactylum tricornutum CCAP 1055/1
XP_001732379  511 RAIQESGADV 520  Malassezia globosa CBS 7966
NP_594951     543 KAVMYTSKDL 552  Schizosaccharomyces pombe

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