Conserved Protein Domain Family
HTH_MerR1

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cd04783: HTH_MerR1 
Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator
Helix-turn-helix (HTH) transcription regulator MerR1. MerR1 transcription regulators, such as Tn21 MerR and Tn501 MerR, mediate response to mercury exposure in eubacteria. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines that define a mercury binding site. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133410
View PSSM: cd04783
Aligned: 24 rows
Threshold Bit Score: 157.387
Threshold Setting Gi: 103487108
Created: 19-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                       ###                                    
AAC33922      8 LTIGVFAKAAGVNVETIRFYQRKGLLRe--PDKPYg-----SIRRYGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDgt 80  Escherichia coli
ZP_00053028   6 LTIGRAAAKAGVSVETIRFYERRGLIEq--PPKGE------GYRVYPTEMVARIRFIRQAQQIGFSLREVQELLSLRAdp 77  Magnetospirillum...
ABD94723     32 LSIGQLAAAAGVSVETIRFYQRQGLLVe--PAKPIg-----GHRRYDAAVVTRLRFIKRAQVLGFTLAEVAGLLSLDQaq 104 Pseudomonas aeru...
YP_145584     5 LTIGKLAEAAGVNIETIRYYQRRGLLDe--PPKPLg-----GQRRYSAELAGRVRFIKRAQALGFTLDEVSALLALDSac 77  Ralstonia metall...
ZP_01351590   3 FTIGRLAQLAGVNIETIRFYERRGLLIq--PIKPLt-----GYRQYDDQALSRIRFIKRAQEVGFTLSEIQSLLDIESn- 74  Psychromonas ing...
YP_760097    29 LTIGKLAQAGGVGVETVRFYQRRNLLGt--PSRDG------GIRRYDTEDVRRLRFIRKAQHAGFTLEEIRELIELDSgh 100 Hyphomonas neptu...
YP_616669     3 MTIGKLAAAGDVGVETIRYYQRRGLMGt--PARSGgdgwggGVRRYGDDDLRRLRFIRAAQAAGFTLDEIGELLALDQsd 80  Sphingopyxis ala...
YP_497395     3 MTISELAKGAGVGVETVRFYQRKGLLDdprPSRTAr----qGQRHYGPEDLRRLRFVRSAQAAGFTLAEISELLALDAgh 78  Novosphingobium ...
YP_617475     4 MTIGQLARQGGVNVETIRYYQRRGLLPv--PPQSAsapsegRVRRYDEAVLRRLRFIKSAQAAGFTLTEIAELLELDAss 81  Sphingopyxis ala...
ZP_01381584  33 MTVGRLAKVAGVGVETIRYYQGRGLLP---VPKAAg-----SFRRYPASMVQRIGFIKRAQSLGFSLDEVGSLLDLEDgr 104 Acidovorax sp. JS42
Feature 1                                                              
AAC33922     81 --hCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHARkgnVSCPLIASLQ 133 Escherichia coli
ZP_00053028  78 tadCADVRRQAAQKIEEVDRKIADLQRVRAALETVVSVCPGKgglTDCTIMAALE 132 Magnetospirillum magnetotacticum MS-1
ABD94723    105 aqaCADTREFAAHKVAVLDQKMQDLAAMRSTLVALIQQCDEGgneNCCPIIQSLE 159 Pseudomonas aeruginosa
YP_145584    78 --aCSKTRELASRKLALIKQKMADLATMQQVLDALIQQCDAGsvgADCPIIDVLA 130 Ralstonia metallidurans CH34
ZP_01351590  75 --nCNKVQHLAMEKLTLTRQKITDLQHLEKSLQHLVTQCEITqnkTHCPIVDSFN 127 Psychromonas ingrahamii 37
YP_760097   101 --dHHRAREMAETRLTKLDEQIAELQRAKQSLQRLATECAAGk-sGSCPILDAFE 152 Hyphomonas neptunium ATCC 15444
YP_616669    81 --dRARVRALARQRIDALDAKIAQMTATRAALARLADQCAASe-tGPCPIMAAFE 132 Sphingopyxis alaskensis RB2256
YP_497395    79 --dRPRAREMARARLHAIEQEIARLEAARQSLRKLARECAKGd-aGPCPIIAAFE 130 Novosphingobium aromaticivorans DSM 12444
YP_617475    82 --dRARARELADARIAAIEKTIAELDVARRALMGLSRQCAAAd-tLHCPIIAAFE 133 Sphingopyxis alaskensis RB2256
ZP_01381584 105 --nRRAIQTVTQRRLEQIDEKVGDLERMRGALRDMLARCEETgqaFPCPIIAALV 157 Acidovorax sp. JS42

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