Conserved Protein Domain Family
LbH_eIF2B_gamma_C

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cd04652: LbH_eIF2B_gamma_C 
eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is important for regenerating GTP-bound eIF2 during the initiation process. This event is obligatory for eIF2 to bind initiator methionyl-tRNA, forming the ternary initiation complex. The eIF-2B gamma subunit contains an N-terminal domain that resembles a dinucleotide-binding Rossmann fold and a C-terminal LbH domain with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). The epsilon and gamma subunits form the catalytic subcomplex of eIF-2B, which binds eIF2 and catalyzes guanine nucleotide exchange.
Statistics
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PSSM-Id: 100057
View PSSM: cd04652
Aligned: 27 rows
Threshold Bit Score: 101.885
Threshold Setting Gi: 76157257
Created: 12-Oct-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NR50       357 LIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNnAVIEKgADIKDCLIGSGQRIEAKA 436 human
BAD61920     362 MLAEGSQLGDKCSVKRSVIGRHCRIGSNVKIVNSVVMNHVVIEDGCHIQGSVICNnVQLQErAVLKDCQVGAGYIVTASS 441 Japanese rice
NP_001031908 367 MLGEGSQVGDKCSVKRSVIGRHCRIGSNVKIVNSVVMDHATIGDGCSIQGSVICSnAQLQErVTLRDCQVEAGYVVCAGS 446 thale cress
XP_001632641 351 MVDASVSIGDKVSVKRSVIGKHTTIGDKVKISNSVIMDHVTIKDGCNITSSIVCNnAYIKEnASLKDCQVGNSHTIGEGG 430 starlet sea ane...
EAR84576     349 NIADKSQIGPKVQINKSIIGPQCKIGDGVKISNCIIFKEVTIEQGCVLQNCIIGNkATIKQnSKLNDCQIGVNGVVEANS 428 Tetrahymena the...
AAW45625     451 VLGEGTRVGEKTSIKKCIIGRHCVIGKGAKLNNCVIWDFVTVEENARIENSIICSnGRIGEkAQVKDCEFGTGFEAKPGA 530 Cryptococcus ne...
P56288       371 MVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASgAQIGAkSKLRECEIGVDHRVEAGR 450 fission yeast
NP_611046    357 IAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHrAQVKSgSVLKNCIIGPNYVVEEGT 436 fruit fly
EAT36481     359 AVGDQTVVSEKTSINSSIIGANCVINPKVRLTNCTLMDHVIIEESVTMENCIVCEkSVIKSgSSLRNSLIGSNYIVSANT 438 yellow fever mo...
XP_971487    358 VVWEGAKLHEKTSFKNSVIGANSEVCSFSRVFNCIVMNNVTIKEKVALENCIVSDgVTIEKgCQIKGCLIGSHHLVPENS 437 red flour beetle
Q9NR50       437 K 437 human
BAD61920     442 E 442 Japanese rice
NP_001031908 447 E 447 thale cress
XP_001632641 431 E 431 starlet sea anemone
EAR84576     429 S 429 Tetrahymena thermophila SB210
AAW45625     531 I 531 Cryptococcus neoformans var. neoformans JEC21
P56288       451 I 451 fission yeast
NP_611046    437 H 437 fruit fly
EAT36481     439 K 439 yellow fever mosquito
XP_971487    438 E 438 red flour beetle
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