Conserved Protein Domain Family
ZnMc_MMP_like_2

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cd04276: ZnMc_MMP_like_2 
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.
Statistics
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PSSM-Id: 239803
Aligned: 23 rows
Threshold Bit Score: 168.272
Created: 26-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Comment:Based on similarity to sequences with know structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
YP_593512    290 AALSEPVKPITFYLDRAMp----------ePIRSAARQGALWWNQAF--EQAGFKNAlv-------vEDLPEGad--plD 348  Acidobacteria ...
CAE78573     272 WSIDEKDGDIRVLIDANVp----------qKMEAAVREGVTYWNRVL--GRDILKVEtg-------yKDSDPQ------T 326  Bdellovibrio b...
NP_422151    294 AARSPVKTPIVFYIDRAAp----------ePVRSALMDGARWWAEAF--DAAGFIDAfk-------vEVLPEGvs--plD 352  Caulobacter cr...
ZP_00639375  281 DAPSKVVKPIVYYLDPGAp----------ePIRSALLEGARWWESAF--TDAGFIDGfk-------vELLPEGad--pqD 339  Shewanella fri...
CAE79699     273 WDISPEKGPIKVRVSEAVp----------eDYLAAVTEGALYWNKVF--GRDVIQVVtg-------vSVDAKP------E 327  Bdellovibrio b...
ZP_00522574  328 AAVSEPVKPIEYWVDSGAp----------eDVKKALVEGASWWNQAF--EAAGFRNAfk-------vAVLPESad--pmD 386  Solibacter usi...
YP_446527    322 DGLCPPEEPIVYYLDPGTp----------ePVRSALLDGARWWAEAF--EAAGFEDAyr-------vEVLPDSad--amD 380  Salinibacter r...
NP_716042    289 NRFNPAKSELTYYLSNNFyda------knkPFLDAAIESVTAINIQNklYKTGFPQIk--------lEQANDKrh---gD 351  Shewanella one...
NP_934106    287 NRFDPRKEKIEYHLSDEFfrkdangnlvnkVWLDATVKGFEYMNKSL--ADKFSPNGrlvpelvlinKDATEPsnvkvgD 364  Vibrio vulnifi...
AAO11301     309 HRFNPSLEFIDYHLSDSFdqne-----etrFFKQVTKDVIDRINPQL--EKVGVPKI----------RLHEPSgkl-sgD 370  Vibrio vulnifi...
Feature 1                                                                                        
YP_593512    349 MRYPTIQWTNRs--gRGWSVGmvqTDPRTGEILHAIVQLDSHRMRTVHNYWNVLQPpsanaepdpgifsel--------- 417  Acidobacteria ...
CAE78573     327 DRSIVIRWIHWd--hGFGAYAnaqMDPLTGEAFRGFVYMTSSFTKKDDMKPDNGGGvfsfkhgdlcg------------- 391  Bdellovibrio b...
NP_422151    353 ARYSVVNWVHRq--tRGWSYGhavVDPRTGEIVKGDVLLGSQRIRQDRLIFEGLAGsdatgkggp--------------- 415  Caulobacter cr...
ZP_00639375  340 VRYNMIQWVHRa--tRGWSYGaavTDPRTGEIIKGNVTLGSLRVRQDHLIARGLTAgwpdrkaaa--------------- 402  Shewanella fri...
CAE79699     328 DRSIIVRWIPWl--dSGAAYAigqSDPLTGELLRAQVFMPSVFTSVGSADLVKLNGdvpvvaagaiacdltesll----- 400  Bdellovibrio b...
ZP_00522574  387 IRYNMINWVHRs--tRGWSMGgtvADPRTGEIIKATVTLGSLRDRQDYLIFEGLLSpyatgnekp--------------- 449  Solibacter usi...
YP_446527    381 VRYNVIQWVHRr--tRGWSYGasvTDPRTGEILKGHVTLGSQRVRQDYLLAEGLLApyqgaradgfp------------- 445  Salinibacter r...
NP_716042    352 LRYSNITLFDEpldnGLAGYGpsaANPLTGEIVSARVNQYSSNLKQGAVRYYRQVRldynrgkldansvtsltgepyvsn 431  Shewanella one...
NP_934106    365 IRTNVIHIIPEaseaGLLGFGpstSNPLTGEILSAYTIMYPGVAQMGVGTAWDELVelynkkelatpydvqpyglgssaa 444  Vibrio vulnifi...
AAO11301     371 LRYNVINLIDEpldnGLAGYGpsaVNPLTGEIVHAHVNQYSGVLRSISDWLWDRIAqdynkgrvelvakpdtgstsnatn 450  Vibrio vulnifi...
Feature 1                                                                                        
YP_593512        --------------------------------------------------------------------------------      Acidobacteria ...
CAE78573         --------------------------------------------------------------------------------      Bdellovibrio b...
NP_422151        --------------------------------------------------------------------------------      Caulobacter cr...
ZP_00639375      --------------------------------------------------------------------------------      Shewanella fri...
CAE79699         --------------------------------------------------------------------------------      Bdellovibrio b...
ZP_00522574      --------------------------------------------------------------------------------      Solibacter usi...
YP_446527        --------------------------------------------------------------------------------      Salinibacter r...
NP_716042    432 lnkpdvsldtapveaaafeqptqqliaapksllltpkdnsfdaladfde----------------------ktqafwsen 489  Shewanella one...
NP_934106    445 lnrderfvdlskntivgqpetvqelqqsiskvqeqfsevvseensvqeadil----------------gkqtelemmman 508  Vibrio vulnifi...
AAO11301     451 stgesttsnsvasiteasqstevvslgdmvafeqspmanesmadviaavkeeleandenvsfedlsaikelerrlwaenn 530  Vibrio vulnifi...
Feature 1                                                                                ##  #   
YP_593512    418 --------------------------------------------------dradprltedeamtRRLALLTCHEMGHVLG 447  Acidobacteria ...
CAE78573     392 -----------------------------------------------------mrmdmdpsdqeDSVRAVIAHEMGHVLG 418  Bdellovibrio b...
NP_422151    416 --------------------------------------------------------ndpieislARLRQLATHEIGHSIG 439  Caulobacter cr...
ZP_00639375  403 --------------------------------------------------------naamelslARIRQLAAHEVGHTLG 426  Shewanella fri...
CAE79699     401 ---------------------------------------------alnkiareagdsqrlrlaqDSVRATVAHELGHALG 435  Bdellovibrio b...
ZP_00522574  450 --------------------------------------------------------silyqtalARIRQLAAHEVGHTLG 473  Solibacter usi...
YP_446527    446 -----------------------------------------------------pgddpmlemalARIRQLSAHEVGHTLG 472  Salinibacter r...
NP_716042    490 smmhvdtvfatggsdrelprgikgheidwkkadmwvdgkvggklaafedlpislqdtlttalaaQAFAGTLTHELGHTFG 569  Shewanella one...
NP_934106    509 nmfpaefsgvsasmvanktditeldffeegmfvdstlpedaltlktwnelnlaqrakvslafstHQYLTTLVHEVGHNLG 588  Vibrio vulnifi...
AAO11301     531 mypvsalrsgatlkslpssiggmsfnfqdaslwnngqigevgslkewadltekqqeelslfivgVFYAKTLVHELGHNFG 610  Vibrio vulnifi...
Feature 1          #                                                                             
YP_593512    448 LDHNFVASTFg-------------------------RGSVMDYFaprvkiradg-tadmsdaymQGVGSYDKFAIEWGYS 501  Acidobacteria ...
CAE78573     419 LRHNFAGSSStehtdaeikeainqrkngnlvaeksvVTTVMDYTddvaslv-------sgafikDNVMPYDKKAIDWAYK 491  Bdellovibrio b...
NP_422151    440 LQHNFAASAYg------------------------gRASVMDYPapkialkdg--kldftdaygRGVGDWDKFAIDWLYG 493  Caulobacter cr...
ZP_00639375  427 LDHNFAASTNd-------------------------NASVMDYPhpyvsiqgd--nidiatpytEGMGEWDKYTIAYGYG 479  Shewanella fri...
CAE79699     436 MRHNFAGSSSakvstqeiydsaktylrdpnhqgletSTSIMDYVsgiddil-------msgrikYSALSYDKMAMDWAYS 508  Bdellovibrio b...
ZP_00522574  474 LGHNYYDSSAg-------------------------WISVMDYPhpqeklredg-tidltdaypASIGEWDKVAINYGYR 527  Solibacter usi...
YP_446527    473 LAHNFAASVNd-------------------------RASVMDYPaplarvegd--sislkeaydTGVERWDVKALQYAYA 525  Salinibacter r...
NP_716042    570 LRHNFAGSRDhdntfnqa-----------qlkelkaAFSDAGYPditvnaefssqmdynvnrfaTTFEPYDLAALRFGYA 638  Shewanella one...
NP_934106    589 LRHNFKGSFDgdnffteaqa------rsldlkgvsaTSSIMDYTpsei-------------gvhPAFGLYDRAALRFAYQ 649  Vibrio vulnifi...
AAO11301     611 LRHNFKGSNDasnyfkdhel------aehglkvvpgYSSIMDYNpsll-------------nalPVFGPYDLAALRFGYK 671  Vibrio vulnifi...
Feature 1         
YP_593512    502 T 502  Acidobacteria bacterium Ellin345
CAE78573     492 D 492  Bdellovibrio bacteriovorus HD100
NP_422151    494 P 494  Caulobacter crescentus CB15
ZP_00639375  480 G 480  Shewanella frigidimarina NCIMB 400
CAE79699     509 E 509  Bdellovibrio bacteriovorus HD100
ZP_00522574  528 Q 528  Solibacter usitatus Ellin6076
YP_446527    526 R 526  Salinibacter ruber DSM 13855
NP_716042    639 R 639  Shewanella oneidensis MR-1
NP_934106    650 R 650  Vibrio vulnificus YJ016
AAO11301     672 R 672  Vibrio vulnificus CMCP6

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