1MMR,1KAP,1IAB


Conserved Protein Domain Family
ZnMc_MMP_like

?
cd04268: ZnMc_MMP_like 
Click on image for an interactive view with Cn3D
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.
Statistics
?
PSSM-Id: 239796
View PSSM: cd04268
Aligned: 48 rows
Threshold Bit Score: 69.0623
Threshold Setting Gi: 16413776
Created: 23-May-2006
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1MMR         12 SKVVTYRIvsytrdlphiTVDRLVSKALNMWGKei-pLHFRKVvwg--taDIMIGFargahgdsy--------pfdgpgn 80
gi 89091427  40 QNSATIYVnis-----npVLKNATETAIAQWNNtk-aFTFKIVndk--naNISVSAvndpnngaa-------gltntsmn 104
gi 62422056 101 TNQATVYVntn-----naQLDAATNTAIQSWNQtg-aFTFKPVnnq-skaDIVVTTmnrsdsnaa-------gltktssn 166
gi 28272306  41 DKQAANYQdls----ssdYYKDVWNNATASWKKa--gFTWTKAat----aKTTVSSydgssdmtla------gynsvsyn 104
gi 16413776  39 AKNFKVYIngs-----arGYRNIIINGAKSWNPspylNTVTMGndv--kpNFTVSSsntnkgsvl-------avcnttyy 104
gi 28270100  42 HAQVTYVIqa------ssYERHVYQAAIQAWNAtg-hFKFVPGtta--hhQITLGTsnatsgqyyr------lagitfst 106
gi 58254979  82 TASIFIYInq------ndPNYQTVQDAIKAWNAtk-vIKFKQAfny-qkaQIIVTAhdygdtsw---------aglteip 144
gi 28270310  83 SRVITYRItsd-----skVYRAIWLRAVERWNNtn-aVRLVEAkdq-akaQITLGEsedetet-----------tgseig 144
gi 28272261 117 KKTYYYSFdhn----vpkAARQVFLEAVATYNQtg-lVHLVAGqasgsqnSVTFSMyhkkmttgatsvelghggpditkq 191
gi 48869940  72 NKYYYSYQagt-----pdAVQNVFKRAIATYNAtg-iVKIVPGaeqgwlnHLELGTyrkn-----------------vpl 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  ##  #     #          
1MMR         81 tLAHAFapgt-------------------glgGDAHFDederwtdg-sslginflYAATHELGHSLGMGHSsd-pNAVMY 139
gi 89091427 105 sATGYYl------------------------hATVELNsyyllnpafgysqerivNTAEHELGHAIGLQHTn--kISVMQ 158
gi 62422056 167 sLTRRFm------------------------hATVYLNtyyltdpsygysqerivNTAEHELGHAIGLDHTn--aVSVMQ 220
gi 28272306 105 kSTGEIt------------------------sSKVRINravfekyn--ytkaertNVAEHELGHALGIGHNntdsVSVMN 158
gi 16413776 105 kSNKLIvk----------------------neITLYKGfrsls-------nnhkiETVAHEFGHGFGLGHVkt-rNAIML 154
gi 28270100 107 gYTNGYyt-----------------------kAQVYLLtrnfvryh--ysytdqvHVAEHELGHTIGLEHSrd-rHSVML 160
gi 58254979 145 dTPRGYly-----------------------gSVVYLNnfylrqs----tpqvalSVAEHELGHAIGLQHNdt-qPSVMN 196
gi 28270310 145 rTWRTYyqsgsqgt-----------twmdsakCVIYTNrfpasnh----sveyklSVATHELGHALGLEHEnn-kSAVMY 208
gi 28272261 192 iSWRGTqyw---------------------nnATASLNgsyas--------afskSVAVHELGHALGLDHSss-tESVMY 241
gi 48869940 129 nQSRTIelgiggpkimeqtgvvsrianhasakLNIYYNkav------------sqAVATHEVGHALGLDHSqa-eDSVMY 195
                       170       180
                ....*....|....*....|....*
Feature 1                                
1MMR        140 PtygngdpqnfKLSQDDIKGIQKLY 164
gi 89091427 159 Pags-----yyPIQSRDIEAVKALY 178
gi 62422056 221 Pags-----fyTIQPDDVQAVQKLY 240
gi 28272306 159 Panr-----yyTIQACDINGMKARY 178
gi 16413776 155 Dkgfi---nktKPQKDDFNGIKALY 176
gi 28270100 161 Adnr-----ynGISAADSAAVRLRY 180
gi 58254979 197 Ssvte--qnayTIQPCDIAAVKAIY 219
gi 28270310 209 Yqsh----raaHITTREISTLKQMY 229
gi 28272261 242 Pvsq----gksTLSSADIAALQTIY 262
gi 48869940 196 Pldr----eqtALSPADLAGLKSIY 216

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap