Conserved Protein Domain Family
eIF-2B_epsilon_N

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cd04197: eIF-2B_epsilon_N 
The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2.
N-terminal domain of epsilon subunit of the eukaryotic translation initiation factor 2B (eIF-2B): eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2.GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit epsilon shares sequence similarity with gamma subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex.
Statistics
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PSSM-Id: 133040
View PSSM: cd04197
Aligned: 22 rows
Threshold Bit Score: 220.942
Threshold Setting Gi: 23488910
Created: 3-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P32501      27 LQAVVLTDSy-ETRFMPLTAvkPRCLLPLANVPLIEYTLEFLAkaGVHEVFLICSshANQINDYIENskwnlpws----- 100  baker's yeast
AAG38017     9 VQAVLIADNn-VWNFKPLSDegSTALVPLVNVRMLDYALMALNrsGVEEVFVYTSlyRSSIREHIRAgiatdaaws---- 83   fruit fly
CAD98383    26 LPAVVVVESlgVDSFLPISCefPESLLPINGVPIINYIIEMLLknGVTEIYLLAYshKDLLMDHIEGlkssnkklr---- 101  Cryptosporidium ...
EAA21432    20 VVGLLVENNf-DEVYEPLTSesLRFFLPLNGLYVIDYQLHFFKynDIKKIYIVVThhEKELQSYVEKfqkskrkyn---- 94   Plasmodium yoeli...
EAR85097    20 FQAVLLADTy-VTRLAPITKeiPKCLLPVANVPLIEHTINWLEanKIYELLVVYTshSQKIEQYFSQrdkssmkiqliha 98   Tetrahymena ther...
CAL54860    14 LQAVVLADSf-GHALKPLTCnvAKVLLPLAGCPMLEYSLEWLAtqGVEECVVVACscSESVERYLKSrdgrigggeg--- 89   Ostreococcus tauri
EAT42872    10 VQAILIGDGf-NDCFIPFTDrkPLSLLPLVNVPLLDYSLESLNrsGVEEVILFCSnhVDQVKAHVKArqsagcsws---- 84   yellow fever mos...
EDQ74618    17 LQAVVLADSf-TQKFRPITLekPKVLLPLVSVPLIDYTLEWLAyqGVEECFVFCCahANQVTNHLAKskwrsqpn----- 90   Physcomitrella p...
NP_181042   25 LQAILLADSf-ATKFRPVTLerPKVLLPIVNVPMIDYTLAWLEsaGIEEVFVFCCahSMQVIEYLEKsewyshpn----- 98   thale cress
XP_972918   10 IQAVVVADTf-GDEFLPLSSdiPLALFPLINRPLIDYTLEFLSlgGIEETFLFCCshTDAIKAHINQsvkdkagws---- 84   red flour beetle
P32501     101 --------pfkittimSPEARCTGDVMRDLDNRGii----tgDFILVSGDVLTNIdfskmLEFHKKMHLQDKDHISTMCL 168  baker's yeast
AAG38017    84 -------fkmtvhvigGEGCRCFGDAMRDLDNKAli----rgHFILLGADTVTNAdlrpvLEQHKRQAKFDKGTAATLVF 152  fruit fly
CAD98383   102 -------slniqiiqlGVHCNSIGDALRDLDCQVdi----rdDFVLIQGGLLCVAdikevVQIHKKKRSSQVPNLSMTMI 170  Cryptosporidium ...
EAA21432    95 -------dldieiikmNKKTKSLGDVLRDFKKCKdv----ydDILLLLSDTIPISnikeiIKAHFINKEKCKNQIMTLLL 163  Plasmodium yoeli...
EAR85097    99 hdaktqleyiqhnlflFANQKSVGDALRELQYKGvv----ygDFLLCYGDMVSNIklqsaIKHFLWKKKENSLNIMTAIL 174  Tetrahymena ther...
CAL54860    90 ------rggmitqcvsGTACVSAGEALRLIEQRRvi----rgDFVLVSGDVVTNVdlsdaLRTHRERRKKEKLAIMTVLL 159  Ostreococcus tauri
EAT42872    85 -------igmsvtivsSEGCRCMGDALRDLDAKGlm----rgNFLLMGVDTVTNAnlaaiLEEHKRTAKADKGTAMTVVF 153  yellow fever mos...
EDQ74618    91 ---------fsvtpieSHDCVSAGDALRLIEQRGvv----rgDFVLVSGDTVSNMslkevIKEHQERRKNDKLAVMTMVV 157  Physcomitrella p...
NP_181042   99 ---------llvrtieSHKSISAGDALRYMYEQQtetsqiqgDFVLVSGDTVSNMpladlIQEHRERKKKDEKAIMTMVI 169  thale cress
XP_972918   85 -------ltmkvnvivSESCHSFGDCLRDLDRKGil----rgNFVLLEPGTLSNIkllpiVKKHNEVANKDKGAAMTVIY 153  red flour beetle
P32501     169 SKastypk----trtiePAAFVLDKStSRCIYYQDLPLPSsrekts---------------------------------- 210  baker's yeast
AAG38017   153 KEcannv------rtgnEVLIAVDRRnDRLHYHQRLRMHHkenry----------------------------------- 191  fruit fly
CAD98383   171 FMesppls---tlrtkkNENLVIYDQvSNELVHWGKFDDDycsrlsmk-------------------------------- 215  Cryptosporidium ...
EAA21432   164 THdtndnm----knqdeEFVIAYDNFtLKLLLFEYIKNKNyisitneifdqvnnnsknvkskkkenkpftqvnnkketav 239  Plasmodium yoeli...
EAR85097   175 KKshpfdsn--rtyqddDFAFVVEKQsGDILQIENINKEDyfelnl---------------------------------- 218  Tetrahymena ther...
CAL54860   160 REtgadvre--arygenNLTVAMDSEtQRIVHYEEHHGSAsrtpat---------------------------------- 203  Ostreococcus tauri
EAT42872   154 KEgvpqq------rtgnEVMIAMDKNsKRLLFHQRLKPLHkernf----------------------------------- 192  yellow fever mos...
EDQ74618   158 KRakpspstfharlgndELLLAIDPHsKQLLHYDPGREYGgrdnfqhlps-----------------------------q 208  Physcomitrella p...
NP_181042  170 KQskssplthqsrlgtdQLFIAVDPLtKQLLHYEEDKIDHpsgsv----------------------------------- 214  thale cress
XP_972918  154 QEagigqm---grdlneEVVVAVNNN-NRVLFHRKLGQSRdrkie----------------------------------- 194  red flour beetle
P32501     211 --iqidpeLLDNVDEFVIRNDLIDCRIDICTSHVP 243  baker's yeast
AAG38017   192 ---qlpldVFLGNSCVALHHNLLDPQIAIGSPSML 223  fruit fly
CAD98383   216 tlmrnsssSYYGTSKCIIRYDLLDIGLAICSPQLL 250  Cryptosporidium parvum
EAA21432   240 gersifstLSSSASSIIISCDVLIPNIYIITPDVL 274  Plasmodium yoelii yoelii
EAR85097   219 ---erlkvSKGAALGQKIHYNYLDNQIYICSLDVL 250  Tetrahymena thermophila SB210
CAL54860   204 ---sldasLFGEVENIRVRTNLMDCHIDICAPEFL 235  Ostreococcus tauri
EAT42872   193 ---vipleILTQNKDVTLQHGLVDPQIAVCSNTAL 224  yellow fever mosquito
EDQ74618   209 rnvllersALNDRPSVQLCTNLQDCHIDICSPEVL 243  Physcomitrella patens subsp. patens
NP_181042  215 ---cleksLLDTNPSVLVCNDMQDCYIDICSPEVL 246  thale cress
XP_972918  195 ----fpleIFLENSNVSLHHNLKDTHIAICSPSVL 225  red flour beetle
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