Conserved Protein Domain Family
DPM1_like_bac

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cd04187: DPM1_like_bac 
Bacterial DPM1_like enzymes are related to eukaryotic DPM1.
A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.
Statistics
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PSSM-Id: 133030
View PSSM: cd04187
Aligned: 124 rows
Threshold Bit Score: 157.639
Threshold Setting Gi: 13477058
Created: 4-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Ligand bindingDXD motifPutative
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # #                                                                          
CAB13146       9 IVVPVYNEELVIHETYQRLKevmdq------tkenyELLFVNDGSkDRSIEILRehslidprvkiidfSRNFGHQIAITA 82  Bacillus subtil...
YP_550799      9 LIIPVFNEEENIFPLYKAVTpiinec----adrydfELIFTDNHStDSTFEKLTelsqhdsrvrvfrfSRNFGYQKSILT 84  Polaromonas sp....
ZP_01090941   19 IVVPVLNEEANIQRLYSTVNetmqpv----adryriEFLFTDNHStDRSFELLSniaatdsrvrvlrfSRNFGYQRSILT 94  Blastopirellula...
ZP_01545898    6 VLIPTLNEEDNVRNTYKRVMdvfdql-----pdyepELIFTDNHSsDRTFGILTeiaakdprvrvirfSRNVGYQSSVLT 80  Stappia aggrega...
YP_727338     17 ISIPVLNEAGNINALYARLTavaekm----rdrcdlEFVFSDNHSdDDTWDILKrlaatdprvkairfSKNYGFQRSIFA 92  Ralstonia eutro...
AAZ34642      10 ISIPVLNESGNIEALYSRLDalatrm----kdrcdlEFVFSDNHSdDNTWMMLAelaakdprvkairfSRNYGFQRSILA 85  Pseudomonas syr...
ZP_02087322    6 VLIPCYNEAENVGPISRAVTeileke----lpqydyELVFIDNDStDGTRDIIRglcadnprikailnARNFGQFNSPYY 81  Clostridium bol...
NP_893317      7 ICIPCFNERKNLDELYYRIDkvledi-----kgynfSIIFADNCSkDSSLDFIKelmkkderigyilnVSNFGFVRSSAN 81  Prochlorococcus...
NP_772621     42 LVTPCYNEEAGIRECYAAVKeifdre----lpgyerEHIFCDNASsDRTVEILKeiaaedpsvkvivnARNFGVLRNTYN 117 Bradyrhizobium ...
YP_001018822   5 IVVPTFCEESNLRAHYLACMheleelnkrysqyneyEYLVIDNCSnDSTVDVALilrdsdpnirifvnDQNYGPIWSPFC 84  Prochlorococcus...
Feature 1                        #                                                               
CAB13146      83 GMDYAqg-naIVVIDADLQDPPELIlemiek-wkegyEVVYAVRtkrkg---etffKKQTAAMFYrllsgmtdidiPIDT 157 Bacillus subtil...
YP_550799     85 GYLKArg-daLIQLDCDLQDPPDLIleflkh-wedgcAVVYGVRlsrr----enavLHYSRKLFYrlanylseddlPVDV 158 Polaromonas sp....
ZP_01090941   95 GYLNAsg-eaVIQLDCDLQDPPAMIleflak-wevgyKVIYGVRkqrr----egvgITLARKAFYrlinwlsddplPLDA 168 Blastopirellula...
ZP_01545898   81 AYRAAeg-acAIQLDCDLQDPPELIpqmldt-wrkgyHVVYGIRrslp----dgpvVAWLRRAFYtlidaisqddlPRNA 154 Stappia aggrega...
YP_727338     93 NYLHTrg-daVMQIDADLQDPPELLesffel-wqqgyHVVYGIRkkrp----egwlLNNFRRLGYwvidkisehpiPRDV 166 Ralstonia eutro...
AAZ34642      86 NYMHTkg-daVMQIDADLQDPPEMLeeffar-wqeghEVVYGVRrkrp----egwlLNNFRRLGYwaidkvsehpiPRDV 159 Pseudomonas syr...
ZP_02087322   82 GMLQVtg-dcVIEMVADFQDPVEMIpkyihe-wekgyKIVIGIKtssk----enrlMYWLRSCYYktikklsdveqIEHF 155 Clostridium bol...
NP_893317     82 VLLAPda-daNIFLMSDLQDPPELIpelikqweetenLVIFAVRrtsr----enkiLFLTKKLYYyvlsklsdqkmVRNT 156 Prochlorococcus...
NP_772621    118 GVLAStgdatILFMPADLQDPPSLIptfvkh-wedgyEIVFGIRarre----epflSRTARHMYYkmisrmsyvdyPADV 192 Bradyrhizobium ...
YP_001018822  85 GLLNAkg-daVLLIAADLQEPADLLipfiha-lelgyEAAIGCKkntqenklmwylRGAYYWVLKkigl----vklPMRY 158 Prochlorococcus...
Feature 1                                         
CAB13146     158 GDFRLMDRKVcdemkrlkekNPFVRGLVSWVGS 190 Bacillus subtilis subsp. subtilis str. 168
YP_550799    159 GDFRLIDRKVvdvlrqtddmQPYLRGMIAAMGF 191 Polaromonas sp. JS666
ZP_01090941  169 GDFRLVDRRIvevlrkhqdaTPYLRGQIAAMGF 201 Blastopirellula marina DSM 3645
ZP_01545898  155 GEFRLTDRRIldelrrvedrSPYVRGLISGMGF 187 Stappia aggregata IAM 12614
YP_727338    167 GDFRLIDRKViealsgirtsSPYLRGMIAGLGF 199 Ralstonia eutropha H16
AAZ34642     160 GDFRLIDRKVvnvllktktaNPYLRGMIAGIGF 192 Pseudomonas syringae pv. phaseolicola 1448A
ZP_02087322  156 TGSGLYDREFievlrnlddpTPFLRGIVAELGY 188 Clostridium bolteae ATCC BAA-613
NP_893317    157 TGYGIYDRKVikslrdsidsYPFVKGLVCATGF 189 Prochlorococcus marinus subsp. pastoris str. CCMP1986
NP_772621    193 GDYQLVDRKVldamkqfedvQPFMRMMPFECGF 225 Bradyrhizobium japonicum USDA 110
YP_001018822 159 SGFGLYSRKLle-------vFRTVHITEPSLRV 184 Prochlorococcus marinus str. MIT 9303

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