Conserved Protein Domain Family
Rab39

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cd04111: Rab39 
Rab GTPase family 39 (Rab39)
Found in eukaryotes, Rab39 is mainly found in epithelial cell lines, but is distributed widely in various human tissues and cell lines. It is believed to be a novel Rab protein involved in regulating Golgi-associated vesicular transport during cellular endocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins.
Statistics
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PSSM-Id: 133311
View PSSM: cd04111
Aligned: 6 rows
Threshold Bit Score: 344.821
Threshold Setting Gi: 47213473
Created: 9-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on sequence similarity with other Rab isoforms.
  • Comment:The active conformation of Rab is stabilized by interations between the gamma phosphate of GTP and two critically conserved residues, Thr in switch I and Gly in switch II

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #######         #         ##                          #               
Q14964      7 YQFRLIVIGDSTVGKSCLLHRFTQGRFPglrspacDPTVGVDFFSRLLEIEPGKRIKLQLWDTAGQERFRSITRSYYRNS 86  human
CAF91130    7 YQFRLIVIGDSTVGKSCLIRRFTEGRFAqv----sDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNS 82  Tetraodon nigrovir...
NP_998207   7 YQFRIILLGDSTVGKSSLLKRFTDGIYSdv----aDPTVGVDFYARSIDIEPGVKIKLQLWDTAGQERFRSITTSYYRNS 82  zebrafish
CAA87774   16 YQYRLIVIGDSTVGKSSLLRYFTEGKMAei----sDPTVGVDFYARMIELRPGYRVKLQLWDTAGQEKFRSITKSYYRNS 91  nematode
NP_572405   8 YQFRLILIGDSTVGKSSLLKFFTDGKFAel----sDPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFRSITKSYYRNS 83  fruit fly
AAP06207    7 YQFRVIIIGDSMVGKSSLMKSFVEGNFSpv----sDPTIGVDFFSRTVRIQEEVFVKLQLWDTAGQEKFRSITASYYRNC 82  Schistosoma japonicum
Feature 1                                                ## #                              ###
Q14964     87 VGGFLVFDITNRRSFEHVKDWLEEAKMYvqp---frIVFLLVGHKCDLas---qRQVTREEAEKLSADCg-mKYIETSAK 159 human
CAF91130   83 VGGLLLFDITNRRSFQNVHDWLEEARSHvqp---hsIVFLLVGHKCDLea---qRQVCPAAPGPVGPGRp-tSRPEASAP 155 Tetraodon nigrovir...
NP_998207  83 VGGLLVFDLTNRKTFDHVREWHREVSEHilp---hhMVYILIGHKSDLsr---dRKVTRDEAEQLAADLg-iRYVETSAK 155 zebrafish
CAA87774   92 VGVLAIYDTTNRESFEHVENWVKEAALNlggpspskCVFQLVGTKSDMds---qRQVNYEEGEYFAKYHk-mKFIETSSR 167 nematode
NP_572405  84 VGVLLVYDISNHASFEHIPLWMMEAQRHiep---hrPVFALVGCKLDLinagghREVTTEEAQKFAKQHg-lHFVETSAR 159 fruit fly
AAP06207   83 VGVIIVFDLTDRETFDHISDWYEEARVSikc---saPVFIVVGHKADRrd---eRQVTKIEAQSLAQRLgdyAYIETSSL 156 Schistosoma japonicum
Feature 1                                                                                     
Q14964    160 d--ATNVEESFTILTRDIyel-------------------------------------------------------ikkG 182 human
CAF91130  156 llpGDPAGSGEAGGGLRDalrgdvgprrhqrgarlhradqghlrpgalrrhhhpgglggreerlrpqrgpllgggdqerP 235 Tetraodon nigrovir...
NP_998207 156 c--NSNVERAFELLTRDIyel-------------------------------------------------------mkmG 178 zebrafish
CAA87774  168 t--GDNVNEAFHMIAQEIqnr-------------------------------------------------------vddG 190 nematode
NP_572405 160 s--GANVEEAFRMVTQEVyar-------------------------------------------------------irsG 182 fruit fly
AAP06207  157 t--GQNIEKTFELLAEGIytnvi----------------------------------------------------kgsyN 182 Schistosoma japonicum
Feature 1                                                                            
Q14964    183 EICIQDGWEGVKSGFVPNTVHsseea------------------------------------vkprKECFC 217 human
CAF91130  236 PLPVLIVWKGGRRTRPEGRAFgiggvrpspdmgetagtlrcrndagdsylpdlntssssetfsslqKTCTA 306 Tetraodon nigroviridis
NP_998207 179 EISTRDGWDGVKSGLTAKVLYpaeee------------------------------------aereKSCNC 213 zebrafish
CAA87774  191 ELRPVDGWEGLKTGIMRSQSVclsersf--------------------------------pqnssaGACGC 229 nematode
NP_572405 183 EYKAEDGWDGIKSGFSRPNSLdfnlv-----------------------------------vaepeKSSCC 218 fruit fly
AAP06207  183 ELCAGGVWDGVKQGHNAALAAslanrsih-----------------------------fnqdepktHGDCC 224 Schistosoma japonicum

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