Conserved Protein Domain Family
CLECT_1

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cd03602: CLECT_1 
C-type lectin (CTL)/C-type lectin-like (CTLD) domain subgroup 1; a subgroup of protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins
CLECT_1: C-type lectin (CTL)/C-type lectin-like (CTLD) domain subgroup 1; a subgroup of protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers from which ligand-binding sites project in different orientations. In some CTLDs a loop extends to the adjoining domain to form a loop-swapped dimer.
Statistics
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PSSM-Id: 153072
View PSSM: cd03602
Aligned: 19 rows
Threshold Bit Score: 118.63
Threshold Setting Gi: 47213476
Created: 24-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand binding
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
CAI11979    23 RRYLFINEKKNWTEAQRYCRENYTDLATVDNm-------NDMNQLKncvnn--ggnqNIWIGLhkts--vynWHWSSGdp 91   zebrafish
CAE17650    21 RTHFFVTEQMTWKDAQTYCRKHHSDLSTVTK--------EEAQLLSsntd---atysFSWIGLyedpdradeWIWSGGqm 89   zebrafish
CAF91133   139 RRFYLEERSMNWSDAQAFCRRRYADLAWVRNk-------QENQALRdvs-----rngTAWIGLsk-----qsWRWSDRsq 201  Tetraodon nigrov...
CAF91133    20 NPYYFSNVSSTWLQAQQYCRKRLGDLATVNDl-------EDLEQLAalve---vsnrVMFLGLrrq----waWSVSDGdd 85   Tetraodon nigrov...
XP_693026  228 SEFILINEVKSWTEAQAFCKEFHVDLPTVQMd-------KDRLEIQkassa--vngvKAWVGLygg---iceWRWSYDne 295  zebrafish
XP_688857  150 KPYVLIDLLYTWREAQRYCRRYYTDLVSVRNr-------KEIEQIKklip----lppYAYIGLfr-----dtFLWSSNst 213  zebrafish
XP_688857 1152 QEYIFIPKLMVWNQAQNYCRANHLDLATVQTd-------EDWATLQetafe-vgyygLAWIGLydd---vlyWLWTHNne 1220 zebrafish
XP_686941  343 AEYVLVDTYKSWTEAADYCGQKYIDLASAQTagdwsrftELSAAYSq---------pEAWVGLydd---vdsWRWSYQee 410  zebrafish
XP_694896  278 RGLVFVNESMNWREAQSYCRQKHIDLVSVRNq-------IESQQLEkfikdrnssgsAVWIGLfr-----dtWQWSDQsn 345  zebrafish
XP_686445  411 RQFYILKQRVNVSAAQSLCRVNYTDLVTVCDq-------QDNIKLLqllrn--ssspAGWIGAsrg---nysLKWSNGdd 478  zebrafish
Feature 1                          #   # #      # ####  ###      
CAI11979    92 ---aLFLNWtsgq---pagsDDCAYIIn----gQWCVWKCnVFLPFICYD 131  zebrafish
CAE17650    90 ---eEVDNWdtdqp--ddntQHCVSLNqs--tsKLHDTLCsDMLSFYCMD 132  zebrafish
CAF91133   202 ---aTFLPWktpa----ppqGDCGALDvrgetpAITQANCaGNASFLCSR 244  Tetraodon nigroviridis
CAF91133    86 yregEPAYWnwagd-depsgEACGTIGls---gKWFSSSCsSPMPFFCYN 131  Tetraodon nigroviridis
XP_693026  296 --dlQFSVWaptedpssttqSACAVIGnt---gFWYAKDCtQTKPFFCYN 340  zebrafish
XP_688857  214 ---sSLRNWdlfq---pdiiGDCVAMLdd---kYWMTELCsKAKPFYCYH 254  zebrafish
XP_688857 1221 --svVFTAWftfypdtytkhLDCGTQYfd---gRWYNFHCsELRYFVCMD 1265 zebrafish
XP_686941  411 --alTFTAWesnqpnnyganEDCVMMRpn---gYWRDKKCnLICPFVKDD 455  zebrafish
XP_694896  346 ---sSFRYWktkqp-ydqigEECAVIEkyt-qvQWADYTCeHQFPFVCHE 390  zebrafish
XP_686445  479 --vsYSRYSlny-----snqSRCAAMTvn---gDWESILCtETKHFMCYK 518  zebrafish

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