1XWE,2A73


Conserved Protein Domain Family
NTR_complement_C345C
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cd03574: NTR_complement_C345C 
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NTR/C345C domain; The NTR domains that are found in the C-termini of complement C3, C4 and C5, are also called C345C domains. In C5, the domain interacts with various partners during the formation of the membrane attack complex, a fundamental process in the mammalian defense against infection. It's role in component C3 and C4 is not well understood.
Links
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Statistics
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PSSM-Id: 239629
Aligned: 13 rows
Threshold Bit Score: 135.214
Created: 28-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XWE_A          7 CGQMQeeld------ltisAETRKQTACKpe-iAYAYKVSITSITVEn---vFVKYKATLLDIYKTGE-AVAEKd--SEI 73   human
2A73_B        846 CFIQKsdd--------kvtLEERLDKACEpg-vDYVYKTRLVKVQLSn---dFDEYIMAIEQTIKSGS-DEVQVg--QQR 910  human
XP_780931    1469 CALCTre-----------pGKSLLDKACEss-dNYALRVTMMSQERIs---gYTVYIGNVTRVVRTGQ-DDVSPg--MLR 1530 purple urchin
2832239      1549 CNIDPcpg--------pytRIDLEGTACAsh-sSYALKIRIDEVEIKe---gFRICKFTVLNPIKTGD-EDVPHq--AQR 1613 purple urchin
BAB47146     1583 CPKETspkkl-----reltQRDLEEKACNd--lDYAFRVIVMEVRQEg---sFDRISMIVESPIKKGL-DDVFDg--EER 1649 Branchiostoma...
AAQ08323     1581 CPPRHpfqgvtqihdisesRKLLLDRACVd--hDYVWKGTVESKRKEn---gFRYISFRVTSVFKEGI-EQKQNilhTSK 1654 Southeast Asi...
CAC85958     1611 CLICQgg-----------sCENMYRKACTs---NYVYIATVTSQPRDawtpgYTSFSVRVDEVIKEGN-DEISVdrnRIR 1675 Ciona intesti...
NP_001027684 1589 CGTCTqn-----------rCYNHRDEGCSa---KYVYKVRVIGVREDs---vFVNLDAVIEDVYRSGS-DNVQNg--TVR 1648 Ciona intesti...
BAA75069     1554 CSDMCedn---------igCYNLHVETCKr---DYVYIIKVESVEETeg-sgYKIFKARIVEVIRSTS-KHIDPk-dDVT 1618 Halocynthia r...
1168986      1474 CLQRHcvelkg--madedrNADRNGNACRa---EYVFIIGVTKVTKTa---sYININAALKTVLKKGM-DQAINv-gARR 1543 inshore hagfish
AAB59537     1605 CPRQRraler----glqdeDGYRMKFACYyprvEYGFQVKVLREDSRa---aFRLFETKITQVLHFTK-DVKAAa-nQMR 1675 human
AAN86548     1597 CSSCKts----------ddSAVVKGLFCTt--yDYAFKGKLLIIDEEd---qWLHLTFEVVEVYKESVtKKITKk-tARI 1660 Swiftia exserta
1352101      1525 CPAKKpkfd------tsitVLHRQEAACVag-iDYAYVGIVDNRTEVg---sFVYYTVNIQTVIKSGQ-DQAIQp-kATR 1592 arctic lamprey

1XWE_A         74 TFIKKVTCtn---------------------aeLVKGRQYLIMGKEAlqiky--nasfRYIYPLDSlTWIEYWPRDTTcs 130  human
2A73_B        911 TFISPIKCrea--------------------lkLEEKKHYLMWGLSSdfwg----ekpNLSYIIGKdTWVEHWPEEDEcq 966  human
XP_780931    1531 HFYIKERCpc---------------------prIKLNGEHTIIGSAGlsfis-dtgadGYKYLLDDrSIVEWWPTKLNkk 1588 purple urchin
2832239      1614 QLFINEGCdcpk------------------vkgRNIGGTFLLVGQKSlkytt-eqgeeRYRYVYGPtSKLEFWPATRKar 1674 purple urchin
BAB47146     1650 VFWKRKTCsg---------------------lqLVEGTTYLLMGKDGtkytd-eqgfdSFRYVITEqSFVAEWPTGAKae 1707 Branchiostoma...
AAQ08323     1655 DLMVRDSCsv---------------------adLDIQQEYVIMGRDGaqfkdedtgilLYRYILDQsTSIFKWTRISVae 1713 Southeast Asi...
CAC85958     1676 QFTTRKECyekckdpvlag----pdrseesqryLKPNMKILLMSNFLdfsmd-rsghvRHDYQMGEgTTVERIIPDSKcv 1750 Ciona intesti...
NP_001027684 1649 TFVIRNDChascrdtdedlrllrnnipakdtrlFKEGRVLLITGSLIerrqn-rnrllQTVYQVDEqTTAERLVTDVAca 1727 Ciona intesti...
BAA75069     1619 SFRIREDCyaesckdprfeeiarkknnaveakfIEEGRHLLVYGSNPtvtea-knepvQYIYELDDnARLEIVPSGEKcs 1697 Halocynthia r...
1168986      1544 SFVIPMHCgkn--------------------lnVSPGDIYLVMGMHNahwr----nsdRTQYVLTSdTWFEKFPLESVcr 1599 inshore hagfish
AAB59537     1676 NFLVRASCrl----------------------rLEPGKEYLIMGLDGatyd----legHPQYLLDSnSWIEEMPSERLcr 1729 human
AAN86548     1661 VYSKKISCdcp-------------------vfaGKIDRHFLIMGKDVgl-------rgSSKVVLGHnVFVKEWPMNDP-- 1712 Swiftia exserta
1352101      1593 LFIVTRSCdgr--------------------lgMETPRQYLLMGRKGetkd----rndRFQYVLDAsSWVEQWPVDEKcn 1648 arctic lamprey

1XWE_A        131 sc------------------------qafLANLDEFAEDIFl-----nGC 151  human
2A73_B        967 dee----------------------nqkqCQDLGAFTESMVv-----fGC 989  human
XP_780931    1589 kn------------------------ldiQTKLLNFEQDAQ-------LC 1607 purple urchin
2832239      1675 n-------------------------aavFDKLVAFEAQMApa----sAC 1695 purple urchin
BAB47146     1708 rkk----------------------fkrvADKFQQLADKIFl-----qGC 1730 Branchiostoma belcheri
AAQ08323     1714 n-------------------------kqlTKAFRWLEKHMVmg---egGC 1735 Southeast Asian horseshoe crab
CAC85958     1751 qir----------------------arvaLPKFQCENPNFHrnpnrqaKC 1778 Ciona intestinalis
NP_001027684 1728 raksvlvrcagnrpprqskcvksrelnaiCENMKRLKESLNd-----iGC 1772 Ciona intestinalis
BAA75069     1698 peilecapnd-------ircnkkkakldkITKLCKINSTLIeah--leGC 1738 Halocynthia roretzi
1168986      1600 l--------------------------psPPASCQVSENFK-------GC 1616 inshore hagfish
AAB59537     1730 str----------------------qraaCAQLNDFLQEYGt-----qGC 1752 human
AAN86548     1713 -----------------------------VDFFKKFVRLLRk-----dGC 1728 Swiftia exserta
1352101      1649 qpn----------------------vqtfCAIKREYEFSMQi-----qGC 1671 arctic lamprey
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