1XWE,1UAP,1UEA,1BQQ


Conserved Protein Domain Family
NTR_like
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cd03523: NTR_like 
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NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.
Links
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Statistics
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PSSM-Id: 239600
Aligned: 10 rows
Threshold Bit Score: -1
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XWE_A     25 QTACKpeiAYAYKVSITSITVEn----------vFVKYKATLLDIYKTgeava----ekdsEITFIKkvtctn------- 83  human
NP_003003 200 EHLCAs--EFALRMKIKEVKKEn----------gDKKIVPKKKKPLKLgpikk---kdlkkLVLYLKngadcpc------ 258 human
XP_693394 223 PSFCKs--DFVVLGRISELTEDh----------dSGHALITVEEILKDek---------mgLRFFGQeplevtllnmdwn 281 zebrafish
1UAP_A     42 SNFCAs--SLVVTATVKSMVREpg---------eGLAVTVSLIGAYKTggldlpspptgasLKFYVPckqcp-------- 102 human
AAD09221  488 KKYCKk--DYAVQIHILKADKAg----------dWWKFTVNIISVYKQgtsri----rrgdQSLWIRsrdiack------ 545 human
NP_067052 517 KAFCGmkySYVLKIKILSAHDKg----------tHVEVNVKIKKVLKStklk-----ifrgKRTLYPeswtdrgc----- 576 human
BAD18703  364 LHYCGs--DFVFQARVLGHHHQa----------qETRYEVRIQLVYKNrsp--------lrAREYVWapghcpc------ 417 human
1UEA_B     10 TAFCNs--DLVIRAKFVGTPEVaqt-------tlYQRYEIKMTKMYKGfqalg----daadIRFVYTpamesvcgy---- 72  human
1BQQ_T     10 QAFCNa--DIVIRAKAVNKKEVdsgndiygnpikRIQYEIKQIKMFKGpd---------qdIEFIYTapaaavcg----- 73  cow
14194748  188 KTYFRnnyNYVIRAKVKEIKTKc----------hDVTAVVEVKEILKSslvn-----iprdTVNLYTssgclc------- 245 human
NP_003003 200 EHLCAs--EFALRMKIKEVKKEn----------gDKKIVPKKKKPLKLgpikk---kdlkkLVLYLKngadcpc------ 258 human
XP_693394 223 PSFCKs--DFVVLGRISELTEDh----------dSGHALITVEEILKDek---------mgLRFFGQeplevtllnmdwn 281 zebrafish
1UAP_A     42 SNFCAs--SLVVTATVKSMVREpg---------eGLAVTVSLIGAYKTggldlpspptgasLKFYVPckqcp-------- 102 human
AAD09221  488 KKYCKk--DYAVQIHILKADKAg----------dWWKFTVNIISVYKQgtsri----rrgdQSLWIRsrdiack------ 545 human
NP_067052 517 KAFCGmkySYVLKIKILSAHDKg----------tHVEVNVKIKKVLKStklk-----ifrgKRTLYPeswtdrgc----- 576 human
BAD18703  364 LHYCGs--DFVFQARVLGHHHQa----------qETRYEVRIQLVYKNrsp--------lrAREYVWapghcpc------ 417 human
1UEA_B     10 TAFCNs--DLVIRAKFVGTPEVaqt-------tlYQRYEIKMTKMYKGfqalg----daadIRFVYTpamesvcgy---- 72  human
1BQQ_T     10 QAFCNa--DIVIRAKAVNKKEVdsgndiygnpikRIQYEIKQIKMFKGpd---------qdIEFIYTapaaavcg----- 73  cow
14194748  188 KTYFRnnyNYVIRAKVKEIKTKc----------hDVTAVVEVKEILKSslvn-----iprdTVNLYTssgclc------- 245 human

1XWE_A     84 ----aelvkgRQYLIMGKEalqikynasfryiYPLDSlTWIEYWPrdttcsscqaflaNLDEFAE 144 human
NP_003003 259 ---hqldnlsHHFLIMGRKv------------KSQYLlTAIHKWDkknke----fknfMKKMKNH 304 human
XP_693394 282 cpcpnitraeGQMIIMGDVhn---------gmAVLQPdSFVATSSv-----------rRVRKLRE 326 zebrafish
1UAP_A    103 -----pmkkgVSYLLMGQVeen--------rgPVLPPeSFVVLHRp-----------nQDQILTN 143 human
AAD09221  546 ---cpkikplKKYLLLGNAedsp-----dqsgIVADKsSLVIQWRd-----------tWARRLRK 591 human
NP_067052 577 --tcpilnpgLEYLVAGHEdir-------tgkLIVNMkSFVQHWKpslg------rkvMDILKRE 626 human
BAD18703  418 ----pmlaphRDYLMAVQRlvspd---gtqdqLLLPHaGYARPWSpa---------edSRIRLTA 466 human
1UEA_B     73 --fhrsharsEEFLIAGKLqd---------glLHITTcSFVAPWNsls--------laQRRGFTK 118 human
1BQQ_T     74 --vsldiggkKEYLIAGKAegn--------gnMHITLcDFIVPWDtls--------atQKKSLNH 120 cow
14194748  246 ----pplnvnEEYIIMGYEdee-------rsrLLLVEgSIAEKWKdrlgk----kvkrWDMKLRH 295 human
NP_003003 259 ---hqldnlsHHFLIMGRKv------------KSQYLlTAIHKWDkknke----fknfMKKMKNH 304 human
XP_693394 282 cpcpnitraeGQMIIMGDVhn---------gmAVLQPdSFVATSSv-----------rRVRKLRE 326 zebrafish
1UAP_A    103 -----pmkkgVSYLLMGQVeen--------rgPVLPPeSFVVLHRp-----------nQDQILTN 143 human
AAD09221  546 ---cpkikplKKYLLLGNAedsp-----dqsgIVADKsSLVIQWRd-----------tWARRLRK 591 human
NP_067052 577 --tcpilnpgLEYLVAGHEdir-------tgkLIVNMkSFVQHWKpslg------rkvMDILKRE 626 human
BAD18703  418 ----pmlaphRDYLMAVQRlvspd---gtqdqLLLPHaGYARPWSpa---------edSRIRLTA 466 human
1UEA_B     73 --fhrsharsEEFLIAGKLqd---------glLHITTcSFVAPWNsls--------laQRRGFTK 118 human
1BQQ_T     74 --vsldiggkKEYLIAGKAegn--------gnMHITLcDFIVPWDtls--------atQKKSLNH 120 cow
14194748  246 ----pplnvnEEYIIMGYEdee-------rsrLLLVEgSIAEKWKdrlgk----kvkrWDMKLRH 295 human
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