1MLW


Conserved Protein Domain Family
eu_TrpOH

?
cd03346: eu_TrpOH 
Click on image for an interactive view with Cn3D
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.
Statistics
?
PSSM-Id: 239462
Aligned: 8 rows
Threshold Bit Score: 560.192
Created: 11-Jan-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
metal bindingcofactor
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1MLW; Human tryptophan hydroxylase with bound iron

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1MLW_A      5 PWFPKKISDLDHCANrVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 84  human
Q92142    143 PWFPKKISDLDKCANrVLMYGSDLDADHPGFKDNVYRKRRKYFADVAMSYKYGDPIPHIEFTEEEIQTWGTVFRELNKLY 222 African clawed frog
AAD01923  144 PWFPRHISDLDKVSNsVLMYGKELDADHPGFKDKEYRKRRMMFADIALNYKWGQQIPIVEYTEIEKTTWGRIYRELTRLY 223 Schistosoma mansoni
NP_990287 107 PWYPKKISDLDKCANrVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPEIEFTEEEIKTWGTVYRELNKLY 186 chicken
XP_707180 149 PWFPQKISELDQCSHrVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEEVKTWGVVYRELTKLY 228 zebrafish
XP_784134 141 PDFPRKISELDQSANrVLTYGEELDADHPKETLNETTKLRKIYVDVSHDVNSGNIIPRVEYTVQETKTWGQVFSELNRLY 220 purple urchin
AAF47444  176 VWFPRKISDLDKAQN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLY 254 fruit fly
AAD30115  186 EWFPKSIYDLDICAKrVIMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELH 265 nematode
Feature 1                                                                                     
1MLW_A     85 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 164 human
Q92142    223 PTHACREYLKNLPLLSKHCGYREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHDSDPLNT 302 African clawed frog
AAD01923  224 KTSACHEFQKNLGLLQDKAGYNEFDLPQLQVVSDFLKARTGFCLRPVAGYLSARDFLSGLAFRVFYCTQYIRHQADPFYT 303 Schistosoma mansoni
NP_990287 187 PTHACREYLKNLPLLTKYCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYT 266 chicken
XP_707180 229 PTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGYLSPRDFLAGLAYRVFNCTQYIRHSTDPLYT 308 zebrafish
XP_784134 221 PTHACEEYMRNFNILKRDGVYREDKIPQLEDVSRFLKDCTGFQIRPVAGYLSSRDFLAGLAFRLFHCTQYVRHSSDPLYT 300 purple urchin
AAF47444  255 VLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYT 334 fruit fly
AAD30115  266 KKHACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPFYT 345 nematode
Feature 1           #    #                                       #                            
1MLW_A    165 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQ-------------LRVFGA 231 human
Q92142    303 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGK-------------LKVYGA 369 African clawed frog
AAD01923  304 PEPDCCHELLGHVPMLADPKFARFSQEIGLASLGTSDEEIKKLATCYFFTIEFGLCRQDNQ-------------LKAYGA 370 Schistosoma mansoni
NP_990287 267 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGQ-------------LRVYGA 333 chicken
XP_707180 309 PEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQ-------------LRVYGA 375 zebrafish
XP_784134 301 PEPDCCHDLLGHVPLLADRSFAQFSQEIGLASLGASDEEINKLTTCYFFTVEFGLCKQDGQ-------------TRAYGA 367 purple urchin
AAF47444  335 PEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADSt------------FKVYGA 402 fruit fly
AAD30115  346 PEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFSIEFGLSSDDAAdspvkengsnherFKVYGA 425 nematode
Feature 1                                                                 
1MLW_A    232 GLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKT 291 human
Q92142    370 GLLSSISELKHSLSGNAKVKPFDPMVTCNQECIITSFQELYFVSESFEEAKEKMREFAKT 429 African clawed frog
AAD01923  371 GLLSSVAELQHALSDKAVIKPFIPMKVINEECLVTTFQNGYFETSSFEDATRQMREFVRT 430 Schistosoma mansoni
NP_990287 334 GLLSSISELKHSLSGSAKVKPFDPKVTCKQECLITTFQEVYFVSESFEEAKEKMREFAKT 393 chicken
XP_707180 376 GLLSSIGELRHALSDKATVKVFDPKTTCYQECLITTFQDVYFVSESFEEAKEKMREFAKS 435 zebrafish
XP_784134 368 GLLSSIGELKHALSEEAKVLPFNPAVTSKQECLITTYQEAYFISKSFEEAKQQMREFAAT 427 purple urchin
AAF47444  403 GLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAES 462 fruit fly
AAD30115  426 GLLSSAGELQHAVEGSATIIRFDPDRVVEQECLITTFQSAYFYTRNFEEAQQKLRMFTNN 485 nematode

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap