1KFQ,3PMG,1KFI


Conserved Protein Domain Family
PGM1
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cd03085: PGM1 
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Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, G-1-P produced from sucrose catabolism is converted to G-6-P, the first intermediate in glycolysis. In the other direction, conversion of G-6-P to G-1-P generates a substrate for synthesis of UDP-glucose which is required for synthesis of a variety of cellular constituents including cell wall polymers and glycoproteins. The PGM1 family also includes a non-enzymatic PGM-related protein (PGM-RP) thought to play a structural role in eukaryotes, as well as pp63/parafusin, a phosphoglycoprotein that plays an important role in calcium-regulated exocytosis in ciliated protozoans. PGM1 belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Links
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Statistics
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PSSM-Id: 100087
Aligned: 30 rows
Threshold Bit Score: 943.191
Created: 1-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1KFI_A; Paramecium tetraurelia parafusin (phosphoglucomutase) binds two sulfate ions and Zn in the active site cleft; defined at 4A contacts.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1KFQ_B      9 RVQVTQPYAGQKPGTSGLRKKVSEAtqpNYLENFVQSIFNTLRkde-lkPKNVLFVGGDGRYFNRQAIFSIIRLAYANDI 87  Paramecium tetraur...
1KFI_A      9 RVQVTQPYAGQKPGTSGLRKKVSEAtqpNYLENFVQSIFNTLRkde-lkPKNVLFVGGDGRYFNRQAIFSIIRLAYANDI 87  Paramecium tetraur...
YP_546033   4 HIISTQPFDDQRPGTSGLRKRVSVFqqpHYLENFVQSIFDAVQv----pAGATLVVGGDGRFYNLEAIQTILKMAAANGI 79  Methylobacillus fl...
AAW57035    4 RTVTTTPFDDQKPGTSGLRKAVPTFqkpHYLENFIQSIFDSLDg----cEGQTLVVGGDGRYYNRQAIQVILKMAAANNI 79  Cyanothece sp. ATC...
P39671      3 KTIKTTPYQDQKPGTSGLRKKVPVFaqeNYAENFIQSIFDALEg----fEGQTLVIGGDGRYYNREVIQKAIKMAAAAGF 78  Agrobacterium tume...
EDN35856    4 QTVSTKPFANQKPGTSGLRNKVIAFqqpGYLENFVQSIFNSLDd----iEGKTLVVGGDGRYYNDVAIQIIVRMAAANGF 79  Francisella tulare...
CAK02027   12 KTVLTTAFEGQKPGTSGLRKKVSVFqqpHYVENFIQSLFENIGp----lEGKMLILGGDGRTFNRTLLQIVLKMAAANGV 87  Bartonella triboco...
CAJ04153    1 MEVTTTAYKDQKPGTSGLRKKVTVFqqpNYTANFVQSTFNALHrq--gaVPDVLVVGGDGRYYTSEAVQVILKVSAANGV 78  Leishmania major
EDQ91492    4 QEVPTQAFDDQKPGTSGLRKKVTVFqqpNYTNNFIQATIDAVTelegslAGATLAVGGDGRFYLPEAIQIIIKMAAANKI 83  Monosiga brevicoll...
AAV49510    4 LQIATRPFADQRPGTSGLRKKVKVFqqpHYLENFVQSIFNAIPd----rAGKTLVLGGDGRFYNREAIQIILRMAAGNGW 79  Acidithiobacillus ...

Feature 1                                            ###                                      
1KFQ_B     88 SEVHVGQAGLMSTPASSHYIRKVNeev-gncIGGIILTASHNPGGKehGDFGIKFNVRTGAPAPEDFTDQIYTHTTKIKE 166 Paramecium tetraur...
1KFI_A     88 SEVHVGQAGLMSTPASSHYIRKVNeev-gncIGGIILTASHNPGGKehGDFGIKFNVRTGAPAPEDFTDQIYTHTTKIKE 166 Paramecium tetraur...
YP_546033  80 GRVLVGKNGILSTPAASCVIRKYKt------FGGIILSASHNPGGPt-GDFGIKFNSANGGPAPEKVTEEIFARSQEMTQ 152 Methylobacillus fl...
AAW57035   80 GRILVGCGGIFSTPAASAVIRKYNa------FGGIILSASHNPGGPn-GDFGVKYNVSNGGPAPEKVTNAIYECTKTINE 152 Cyanothece sp. ATC...
P39671     79 GKVLVGQGGILSTPAASNVIRKYKa------FGGIVLSASHNPGGPt-EDFGIKYNIGNGGPAPEKITDAIYARSKVIDS 151 Agrobacterium tume...
EDN35856   80 AKIIVGQNGIFSTPAVSCVIRKYEa------FGGIVLSASHNPGGPk-GDFGIKYNVSNGGPAPEKITDRIFSETKKINQ 152 Francisella tulare...
CAK02027   88 SRVKMGRGGILSTPAVSHLIRKYHa------HGGLILSASHNPGGPe-GDCGIKYNIANGGPAPNSLCDAIFATSQRLSF 160 Bartonella triboco...
CAJ04153   79 RCVWVGQHGLLSTPAVSTMVRRRRdadgrkaTGAFILTASHNPGGPd-ADFGIKYNSENGGPAPEKLTSQIYEETVKITH 157 Leishmania major
EDQ91492   84 GRLVIGQNGLFSTPAVSALIRQRQl------RGGIILTASHNPGGPt-EDFGIKYNIANGGPAPGSVTDTIFKKSQALTK 156 Monosiga brevicoll...
AAV49510   80 GKVVVGRGGLFSTPAVSTVIRARGa------HGGIILSASHNAGGPd-QDFGIKYNTANGGPAPEKLTDAIWTASRSIQG 152 Acidithiobacillus ...

Feature 1                                                                                     
1KFQ_B    167 YLTvdyefekhINLDQIGVYKFegtrlekshFEVKVVDTVQDYTQLMQKLFDFDLLKGlfsnkdFSFRFDGMHGVAGPYA 246 Paramecium tetraur...
1KFI_A    167 YLTvdyefekhINLDQIGVYKFegtrlekshFEVKVVDTVQDYTQLMQKLFDFDLLKGlfsnkdFSFRFDGMHGVAGPYA 246 Paramecium tetraur...
YP_546033 153 YKIvda---pdVALDIVGEIELa-------gMTVEIIDAVSDYVDLMAKLFDFEAIRQlla-sgFRLRFDAMHAVTGPYA 221 Methylobacillus fl...
AAW57035  153 YKIlda---adINLDRPGSFKLg-------tMDVEVIDSVTPYVELMQQLFDFDKIKSmvssdnFRMCMDSLHAVTGPYA 222 Cyanothece sp. ATC...
P39671    152 YKIsda---adIDLDKIGSFKVd-------eLTVDVIDPVADYAALMEELFDFGAIRSlia-ggFKVVVDSMSAVTGPYA 220 Agrobacterium tume...
EDN35856  153 YFIsdaa-kesVDLDKLGTYKIe-------nTAVEVINSVIDYAELMQQIFDFDKIRKlfa-kgFKVRFDSMCAVSGPYA 223 Francisella tulare...
CAK02027  161 YKIfea---sdVDLDRQGTTFMg-------aMQIDVIDPVVDYVALMQEIFDFDCIAKavt-rgLTFRFDAMHAVTGPYA 229 Bartonella triboco...
CAJ04153  158 IKMapt--lpeVDIHTLGTYTFdd-----ynFQVEVVDSLADYAAYMQEVFDFEAIRAlvqrldFKVHVDSLHGVSGPYV 230 Leishmania major
EDQ91492  157 YQIsda---adVDLSVLGEVRVe-------dMIVEIVDPVDNYATLMQELFDFDALKAyvs-sgIKLHIDCLSGIAGPYA 225 Monosiga brevicoll...
AAV49510  153 YQIldg---adVDIDHAATFWLg-------dMQIEVCDPVAEYAELMARIFDFDALKRlmq-gpFRMRFDALHAITGPYA 221 Acidithiobacillus ...

Feature 1                                                                         # # ##      
1KFQ_B    247 KHIFGTLLGcsKESLLNCDPSEDFGGGHPDPNLTYAHDLVELLdihkkk-------dvgtvpQFGAACDGDADRNMILGr 319 Paramecium tetraur...
1KFI_A    247 KHIFGTLLGcsKESLLNCDPSEDFGGGHPDPNLTYAHDLVELLdihkkk-------dvgtvpQFGAACDGDADRNMILGr 319 Paramecium tetraur...
YP_546033 222 RAILVDCLGadPDAVMNADPLPDFGGGHPDPNLTYAHDLVEIMygd-------------dapDFGAASDGDGDRNMILGk 288 Methylobacillus fl...
AAW57035  223 RALFEQYLGakEGTVQNGTPLEDFGGGHPDPNLVYAHDLVDIMfgd-------------napDFGAASDGDGDRNMILGk 289 Cyanothece sp. ATC...
P39671    221 VEILEKRLGapKGSVRNATPLPDFGGHHPDPNLVHAKELYDDVmsp-------------egpDFGAASDGDGDRNMVVGk 287 Agrobacterium tume...
EDN35856  224 KYIFETLLQapAGTVVNAQPLEDFGGFHPDPNPVNAEDLVKHMrsg--------------kyDFGAASDGDADRNMIVGk 289 Francisella tulare...
CAK02027  230 HEIFEKCLGfsEGTVVNGLPLPDFGGGHPDPNLVYAKALYDLLise-------------qgpDLGAASDGDGDRNLIIGr 296 Bartonella triboco...
CAJ04153  231 DRIFHEGLGvpKTSLFRTNVLPDFGGCHPDPNLTYAADLVHVMgllpdgnanpamkhistvpSFGVAFDGDADRNMILGc 310 Leishmania major
EDQ91492  226 KRIYVDLLGapEDAVVNASPKPDFGGGHPDPNLVYAHDLVAAMqtg--------------ayDFGAAFDGDADRNMILGk 291 Monosiga brevicoll...
AAV49510  222 HEIFEKQLGapAGTVVNGTPLTDFGGGHPDPNLVYAKPLADELfae-------------napDFGAASDGDGDRNMILGr 288 Acidithiobacillus ...

Feature 1                                                                   #                 
1KFQ_B    320 -qFFVTPSDSLAVIAANANLif------knGLLGAARSMPTSGALDKVAAKNgIKLFETPTGWKFFGNLMDAg------- 385 Paramecium tetraur...
1KFI_A    320 -qFFVTPSDSLAVIAANANLif------knGLLGAARSMPTSGALDKVAAKNgIKLFETPTGWKFFGNLMDAg------- 385 Paramecium tetraur...
YP_546033 289 -rFFVTPSDSLALIAANARLvpg----yaqGIAGVARSMPTSAAVDRVAQELdIPCFETPTGWKFFGNLMDAg------- 356 Methylobacillus fl...
AAW57035  290 -nFFVTPSDSLAVLTANATLvpg----yegGIAGVARSMPTSAAADRVAAKLgIDCYETPTGWKFFGNLLDAg------- 357 Cyanothece sp. ATC...
P39671    288 -gMFVTPSDSLAIIAANAKLapg----yaaGISGIARSMPTSAAADRVAEKLgLGMYETPTGWKFFGNLMDAg------- 355 Agrobacterium tume...
EDN35856  290 -qIDVSPSDSLAIMAANAHLipa----yskGIKGVARSMPTSTAVDRVAESLrLPCFETPTGWKFFGNLLDAe------- 357 Francisella tulare...
CAK02027  297 -qQFVSPSDSLAIMVEHAHLikg----yrkGIVGVARSMPTTPAADLVAEKHgLNFFETPTGWKFFGTLLDAg------- 364 Bartonella triboco...
CAJ04153  311 -rFFVNPSDSLAVLAANADCvpfftqssssGLKAVARSMPTSGAVDRVAAAHdFALFEVPTGWKFFGNLMDSkdlyggkd 389 Leishmania major
EDQ91492  292 ngFFVTPSDSVAVLAAQYEHipyl---kknGLQGVSRSMPTGAALDLVAKKLdIEFFEVPTGWKFFGNLMDAg------- 361 Monosiga brevicoll...
AAV49510  289 -hFFVTPSDSLAVLAAHATAipa----yrhGLKGIARSMPTSQAADVVAEALgIAHYETPTGWKFFGNLLDAg------- 356 Acidithiobacillus ...

Feature 1                         #                                                           
1KFQ_B    386 -LINLCGEESFGTGSNHIREKDGIWAVLAWLTILAHknkntdhfvTVEEIVTQYWQQFGRNYYSRYDYEQVDSAGANKMM 464 Paramecium tetraur...
1KFI_A    386 -LINLCGEESFGTGSNHIREKDGIWAVLAWLTILAHknkntdhfvTVEEIVTQYWQQFGRNYYSRYDYEQVDSAGANKMM 464 Paramecium tetraur...
YP_546033 357 -KVTLCGEESFGTGSDHVREKDGLWAVLFWLNILAIkr------qPVETIVKRHWARFGRNVYSRHDYEELPSDAANGLI 429 Methylobacillus fl...
AAW57035  358 -KATLCGEESFGTGSNHIREKDGLWAVLFWLNILAVkg------eSVEKIVRDHWQEYGRNFYSRHDYEEVESGPANELM 430 Cyanothece sp. ATC...
P39671    356 -KVTICGEESFGTGSNHVREKDGLWAVLYWLNIVAArk------eSVKDIVTKHWAEYGRNYYSRHDYEEVDSDAANTLV 428 Agrobacterium tume...
EDN35856  358 -KITLCGEESYGTGSNHIREKDGVWAVLFWLNLVAVtg------kQVDQLIEEHWQKFGRNFYSRHDYEAIDTAIANSIM 430 Francisella tulare...
CAK02027  365 -KVTFCGEESFGTGSHHIREKDGLWAVLFWLNLLAVtg------kTVAQIVQQHWHSYGRFYALRHDYEEVEEDKALAVL 437 Bartonella triboco...
CAJ04153  390 fNPLLCGEESFGTGSNHIREKDGIWASLFWLSVIAKrnapgtplvGVQQIVEEHWATYGRNYYSRYDYEDVSAEAAKAVM 469 Leishmania major
EDQ91492  362 -RLSLCGEESFGTGSNHIREKDGVWASLCWLSVMAGtg------qSIEQILLKHWQDFGRNFFTRYDYENVSSEAGDAVM 434 Monosiga brevicoll...
AAV49510  357 -KITFCGEESFGTGSDHIREKDGLWAVLAWLSVIAHtg------qPVAEIVTRHWQRFGRHYYTRHDYENLPAEIGEQIM 429 Acidithiobacillus ...

Feature 1                                                              # ###       #          
1KFQ_B    465 EHLKTKFqyfeql-------kqgnkADIYDYVDpVDQSVSKNQGVRFVFGDGSRIIFRLSGTGSVGATIRIYFEQFEQQq 537 Paramecium tetraur...
1KFI_A    465 EHLKTKFqyfeql-------kqgnkADIYDYVDpVDQSVSKNQGVRFVFGDGSRIIFRLSGTGSVGATIRIYFEQFEQQq 537 Paramecium tetraur...
YP_546033 430 EHVRAQFaslpgrdf---grytvktCDDFSYTDpVDGSVSQKQGIRILFEDGSRIVFRLSGTGTAGATLRIYLESFEPDi 506 Methylobacillus fl...
AAW57035  431 NRLRSMVgdmkgkty---gnyevaySDDFAYTDpVDGSVSEKQGIRIGFTDGSRIVFRLSGTGTKGATLRVYLESYEPDg 507 Cyanothece sp. ATC...
P39671    429 AILREKLatlpgtsy---gnlkvaaADDFAYHDpVDQSVSKNQGIRILFEGGSRIVLRLSGTGTAGATLRLYVERYEPDa 505 Agrobacterium tume...
EDN35856  431 DSLRERLsslvgaql---ndekvakADDFSYIDpIDGSVSNHQGIRIIFEDGSRIVFRLSGTGTQGATLRIYLEKYESDs 507 Francisella tulare...
CAK02027  438 DHLREHLpqagtei----agflvkkADDFTYHDpVDQSVSTRQGIRIFFENGARLVVRLSGTGTCGATLRLYFEQYEGDp 513 Bartonella triboco...
CAJ04153  470 DTVENTVvddvpnl----ngvacktIDNFSYTDpIDGSVSTKQGVRVLFEDGSRFVLRLSGTGSSGATIRLYLEQYMDSa 545 Leishmania major
EDQ91492  435 TKVRSLIgnqaswptdapsghkiasVDDFEYTDpTNGEVTSKQGLRIIFTDGSRIIFRLSGTGSSGATIRMYIDSYIKDd 514 Monosiga brevicoll...
AAV49510  430 HSIAAQLpvlpgqtl---agreiliADDFAYADpIDGSVSAHQGLRLLFADGARLIFRLSGTGTEGATLRIYHEHLEKDp 506 Acidithiobacillus ...

Feature 1                                                 
1KFQ_B    538 iq---------hetATALANIIKLGLEISDIAQFTGRNEPTVIT 572 Paramecium tetraurelia
1KFI_A    538 iq---------hetATALANIIKLGLEISDIAQFTGRNEPTVIT 572 Paramecium tetraurelia
YP_546033 507 skh-------dqdaQDALADLIAIAHQISELKQRTGRDQPTVIT 543 Methylobacillus flagellatus KT
AAW57035  508 skh-------dvdtQEALSSLIELAEEIAQIKKFTGRDKPTVIT 544 Cyanothece sp. ATCC 51142
P39671    506 arh-------gietQSALADLISVADTIAGIKAHTADSEPTVIT 542 Agrobacterium tumefaciens
EDN35856  508 skf-------siptQQALASLIEIAEDLTNIKSLTGMTEPTVVT 544 Francisella tularensis subsp. novicida GA99-3549
CAK02027  514 rky-------nlnpQEVLQPLQQVALKLLNIQQELGRNRPDIIT 550 Bartonella tribocorum CIP 105476
CAJ04153  546 tvkshlaektlptaSTALKALIGVALQVSKMESLTGRKTPTVIT 589 Leishmania major
EDQ91492  515 aay-------tqdaAVALKPLVELALQLSNLADLTGRTEPSVIT 551 Monosiga brevicollis MX1
AAV49510  507 lrq-------hqdpQRTLRDLIQVGRNLSRLETLTGRKTPTVIT 543 Acidithiobacillus ferrooxidans

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