Conserved Protein Domain Family
ArsC_like
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cd03036: ArsC_like 
Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.
Links
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Statistics
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PSSM-Id: 239334
Aligned: 21 rows
Threshold Bit Score: 147.003
Created: 8-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putativeputative
Feature 1:putative ArsC-like catalytic residues
Evidence:
  • Comment:Based on the known function of arsenate reductase, ArsC.
  • Comment:The catalytic cysteine and the second arginine of the triad is conserved in this subfamily. The first arginine is replaced by an asparagine while the third arginine is replaced by a phenylalanine, similar to Yffb proteins.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                  #                    
NP_345916     2 LEFIEYPKCSTCKKAKQELNQLGVDYKAVHIVEETPSQEVILNWLETSgf---elKQFFNTSGIKYRELGLKDkvgSLSN 78  Streptococcus pn...
YP_000022     5 LKVYEYKNCSTCRNALKFLSGKKVKLEILPIRETPPKKSELKTMLQYLgn---esKKLFNTSGNDYKELGLKDklsSLSL 81  Leptospira inter...
NP_967353     2 LKVYEYAKCSTCVKALKFLDGKKVKYDKLPIVDKAPSQKELKDMLSALkerggsiRNLFNTSGVMYKEMKLSEklpSMTE 81  Bdellovibrio bac...
YP_014986     2 INFYWYPKCSTCKKAKAWLENEHVDFNEVDIKTETPTAEEIQKWHEVSgl---piRRFFNTSGIKYRELGLKDkldTLSP 78  Listeria monocyt...
NP_892630     8 VIFYSYPKCSTCRKASKWLDQNNINYQLIDIVKEQPSKKFLEMALIQFsl---diKKIFNTRGKSYKSIGIDIl--DLTQ 82  Prochlorococcus ...
BAB56994      2 IKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTgv---eiNKLFNTHGAKYRELDLKNklqTLSD 78  Staphylococcus a...
O32175        3 LTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELKALYEKSgl---dlKKFFNTSGMKYRELNLKEklyHMSE 79  Bacillus subtilis
AAP99556      5 LKIFSYARCSTCRKALAWLNLQNIKYKLFDIIDSPPSKEMISDAINQLgd----rKYLFNTSGKIYRSIGASAi-kIMND 79  Prochlorococcus ...
NP_897858     2 LQVYSYSRCSTCRRALSWLKESGLEHTVIDITVDPPSRPTLAKAKEQFgd----rRPLFNTSGQSYRALGAAVv-kAMTD 76  Synechococcus sp...
ZP_00540301   2 VTMYGYPKCSTCVKAKKALETNGVEVDYKHIVDETPSAETIRELHQKSge---plKKFFNTSGQSYRSQGIKDrlpELSE 78  Exiguobacterium ...

Feature 1                      #             #     
NP_345916    79 QEAAELLASDGMLLKRPILVENgtVKQIGYRKSYE 113 Streptococcus pneumoniae TIGR4
YP_000022    82 EEQLDLLSKNGNLVKRPFVLGEg-FGFVGFKEEEW 115 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
NP_967353    82 SEAIKLLSENGKLVKRPFVIGDd-THLVGFKEDEW 115 Bdellovibrio bacteriovorus HD100
YP_014986    79 EEAYKLLASDGMLIKRPLTTNGk-EVTLGFKEEEF 112 Listeria monocytogenes str. 4b F2365
NP_892630    83 KKIIELLSNDGKLIKRPFLIINesKLILGFNESEY 117 Prochlorococcus marinus subsp. pastoris str. CCMP1986
BAB56994     79 DEKLELLSSDGMLVKRPLAVMGd-KITLGFKEDQY 112 Staphylococcus aureus subsp. aureus Mu50
O32175       80 DEQLELLASDGMLIKRPLTTDGe-KVTVGFKEDQF 113 Bacillus subtilis
AAP99556     80 ENVVDLLNSEGGLIKRPFVMHPngRFLIGFNQSIW 114 Prochlorococcus marinus subsp. marinus str. CCMP1375
NP_897858    77 DEALDALVADGRLIKRPFVVAPdgQVLVGFKEEVW 111 Synechococcus sp. WH 8102
ZP_00540301  79 QEQYELLASDGMLLKRPIVTDGq-DVTIGFKEELY 112 Exiguobacterium sp. 255-15

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