Conserved Protein Domain Family
PAZ_CAF_like
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cd02844: PAZ_CAF_like 
PAZ domain, CAF_like subfamily. CAF (for carpel factory) is a plant homolog of Dicer. CAF has been implicated in flower morphogenesis and in early Arabidopsis development and might function through posttranscriptional regulation of specific mRNA molecules. PAZ domains are named after the proteins Piwi, Argonaut, and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic-acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes.
Links
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Statistics
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PSSM-Id: 239210
Aligned: 7 rows
Threshold Bit Score: 180.695
Created: 28-Jul-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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nucleic
Feature 1:nucleic acid-binding interface [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                      
BAD34005   784 ANNKHMTHCHSCRdi-------------dLLQTKDGPFCRCILKNSIVCTPHn-NIFYVISGFL-DLDANSRLPQhdg-- 846  Japanese rice
AAF26098  1461 HEVLEKHENCSTNga------------srILHTKDGLFCTCVVQNALVYTPHn-GYVYCTKGVLnNLNGNSLLTKrns-- 1525 thale cress
CAB88120   775 QEVLLDDKMEETN----------------LIHFANASSDKNSLEELVVIAIHt-GRIYSIVEAVsDSSAMSPFEVdas-- 835  thale cress
NP_912466 1152 ASGLVPARDRGHFsdyq---------nqgKLFMADSCWNAKDLAGMVVTAAHsgKRFYVDCICY-NMNAENSFPRkegyl 1221 Japanese rice
AAF03534  1176 ASGLLPVRDAFEKeveed-------lskgKLMMADGCMVAEDLIGKIVTAAHsgKRFYVDSICY-DMSAETSFPRkegyl 1247 thale cress
XP_463595  674 TAVKLMRRIYSENkrellgifdsdqnvgdLIHLANKSCKANSLKDMVVLAVHt-GKIYTALDIT-ELSGDSAFDGasdkk 751  Japanese rice
XP_473129  801 PIDVSVHASYSSNe---------------SLRLLDGIFSKTDVVGSVVFSPHn-NIFFFVDGILdEINAWSEHSG----- 859  Japanese rice

Feature 1             #   #                 #                                     # #          
BAD34005   847 ---tvVTYKDYFKTRHGLTLTFENQPLLAGSKHVKVRNFLHnyyykke-----------kepgdrYSVELPPELCRIIMS 912  Japanese rice
AAF26098  1526 ---gdQTYIEYYEERHGIQLNFVDEPLLNGRHIFTLHSYLHmakkkk------------ekehdrEFVELPPELCHVILS 1590 thale cress
CAB88120   836 --sgyATYAEYFNKKYGIVLAHPNQPLMKLKQSHHAHNLLVdfneemvvktep-kagnvrkrkpnIHAHLPPELLARIDV 912  thale cress
NP_912466 1222 gpleySSYADYYKQKYGVELIYRKQPLIRARGVSYCKNLLSprfehsdare----gdfsenldktYYVYLPPELCLVHPL 1297 Japanese rice
AAF03534  1248 gpleyNTYADYYKQKYGVDLNCKQQPLIKGRGVSYCKNLLSprfeqsge--------setvldktYYVFLPPELCVVHPL 1319 thale cress
XP_463595  752 -eckfRTFAEYFKKKYGIVLRHPSQPLLVLKPSHNPHNLLSskfrdegnvvenmsngtpvvnktsNRVHMPPELLIPLDL 830  Japanese rice
XP_473129  860 -----ATYAEHFKERFRIELSHPEQPLLKAKQIFNLRNLLHnrlpette--------segrelleHFVELPPELCSLKVI 926  Japanese rice

Feature 1       
BAD34005   913 P 913  Japanese rice
AAF26098  1591 P 1591 thale cress
CAB88120   913 P 913  thale cress
NP_912466 1298 P 1298 Japanese rice
AAF03534  1320 S 1320 thale cress
XP_463595  831 P 831  Japanese rice
XP_473129  927 G 927  Japanese rice

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