1VIZ,2F6X


Conserved Protein Domain Family
PcrB_like
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cd02812: PcrB_like 
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PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-phosphate (G1P) and geranylgeranyl diphosphate (GGPP), the committed step in archaeal lipid biosynthesis. Therefore, it has been proposed that PcrB-like proteins are either prenyltransferases or are involved in lipoteichoic acid biosynthesis although the exact function is still unknown.
Links
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Statistics
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PSSM-Id: 239206
Aligned: 27 rows
Threshold Bit Score: 176.662
Created: 22-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:2F6X; Archaeoglobus fulgidus GGGPS with bound glycerol 1-phosphate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #                                                                           
1VIZ_B     10 KHVFKLDPnkd---lpDEQLEILCe--sGTDAVIIGGSdgv----tedNVLRMMSKvrrflvpCVLEVSaieai---vpg 77  Bacillus subtilis
2F6X_B     10 RHITKLDPdrt---ntDEIIKAVAd--sGTDAVMISGTqnv----tyeKARTLIEKvsqyglpIVVEPSdpsnv---vyd 77  Archaeoglobus fulg...
AAB85058   19 IHLTLIDPeeqt-peeAVEIARAAir-gGTDGIMLGGSttds--seldNTARALREnid--vpIILFPGnttgv---sry 89  Methanothermobacte...
NP_143028  22 LHFVLIDPddts-pevAGKLARVCee-lGVDAIMVGGStgaeg-evldNVVRSIKDnss--lpVILFPGshggi---sry 93  Pyrococcus horikos...
NP_248246  22 VYLTLLDPee----enIEEIAENVk--dYADAIMVGGSigiv---nldETVKKIKKitk--lpIILFPGnvdgl---sry 87  Methanocaldococcus...
NP_394455  17 VHMTLIDPgakp-pqeCARIAEEAem-aGTDFIMVGGStdids-ramdEAISAIKAktd--lkVIIFPGsslmi---spk 88  Thermoplasma acido...
AAM07319   17 VHLTLIDPasqt-perAAEIALAAve-gGTDAIMIGGStgasg-tlldETVIKIKEkvn--vpTILFPGssagl---ssy 88  Methanosarcina ace...
NP_613927  13 CHLTLLDPvdvgpeevPEVLESLVk--aGTDAVMVGGStaha---sqvEAVVEAIReva-dvpVILFPNgpegl---apn 83  Methanopyrus kandl...
NP_930584  13 SIIPILDPfkf---nyEININRLLtfqkYAPFCIIASTdcenfemkvsPFIAAASKikt-ipiITHFPPqkpngfpssph 88  Photorhabdus lumin...
YP_448311  16 LHFTLIDPdeqt-pqeAVEIAKQAkk-aRSDAILVGGSitdq--edlnITVKSIKEevd--lpVILFPGnisgv---sky 86  Methanosphaera sta...

Feature 1                                                                                     
1VIZ_B     78 fDLYFIPSVLNskNADWIVGMHQKAMKEygel-------msmeEIVAEGYCIAnp--dcKAAALTeada--dlnmDDIVA 146 Bacillus subtilis
2F6X_B     78 vDYLFVPTVLNsaDGDWITGKHAQWVRMhyenlqkfteiieseFIQIEGYIVLnp--dsAVARVTkalc--nidkELAAS 153 Archaeoglobus fulg...
AAB85058   90 aDAIFFMSLLNstNPYWIIGAQALGAATvkk---------mgiEALPMGYLVVep--ggTVGWVGdtkpvprnkpDIAAA 158 Methanothermobacte...
NP_143028  94 aDAIFFMSLLNsrNPFFITGAQALGAFTvkk---------fgiEPIPMAYIVVep--geTVGWVGdarpiprhkpKLAAA 162 Pyrococcus horikos...
NP_248246  88 aDAVFYMSLMNsaNTYWVVTAPTLGAITilk---------ynlEPIPMAYLCIepakktAVGYVGeireipqnkpKITAM 158 Methanocaldococcus...
NP_394455  89 aDAIFFMSLLNsgSLEYVVGHQVKAAIPlsa---------mkiEKIPMAYLVFdp--gmTVGRVGkahliprddeKTALS 157 Thermoplasma acido...
AAM07319   89 aDAVFFMSLLNsrDLGYVITNQVLGAPLvyk---------sqiEPISMAYLVVep--ggTVGWVGdakliprkkpDIAAV 157 Methanosarcina ace...
NP_613927  84 aDAVLFMSLLNsrNTYYLIEAQVKGAPLver---------fglESIPTGYLIVgew-gtTVSVVGdarvipfdrvEVIVA 153 Methanopyrus kandl...
NP_930584  89 aDAFFATSVINs-NVEYYSSLSLERESIkqsie-----kygdnCLISSAALVLgn--dkKSQKFVysk----tvdHSTES 156 Photorhabdus lumin...
YP_448311  87 aDALLFMSLLNstNPYWITGAQALSAPSikk---------mgiETIPMGYLIIep--ggTVGWVGdskpiprkksDLAVA 155 Methanosphaera sta...

Feature 1                     # #   #                         ###                     #       
1VIZ_B    147 YARVSELlq---lPIFYLE-YSGVl--GDIEAVKKTKAvle-tsTLFYGGGIkDAETAKQYAe-hADVIVVGNAVYEd-- 216 Bacillus subtilis
2F6X_B    154 YALVGEKlf--nlPIIYIE-YSGTy--GNPELVAEVKKvld-kaRLFYGGGIdSREKAREMLr-yADTIIVGNVIYEkg- 225 Archaeoglobus fulg...
AAB85058  159 YAMAAEFlg---mRLFYLEaGSGApehVPEEMIALVKRct--dqILIVGGGIrSGEDAARVAgagADVVVTGTVVENs-- 231 Methanothermobacte...
NP_143028 163 YALAGQYlg---mRLVYLEaGSGApepVPEEMVRVVKSvi--dvPLIVGGGIkSGEQAKKLIksgADIIVTGTAIEKa-- 235 Pyrococcus horikos...
NP_248246 159 YCLSAKFfg---mRWAYLEaGSGAsypVNNETIALSKKls--giNIIVGGGIrKPEIAYEKVlagADAIVTGNLLEEn-- 231 Methanocaldococcus...
NP_394455 158 YALAAQYfg---fRLVYFEaGSGSpyhVGENVVRRVKQel--diPVIVGGGIrTPEAAKALAqagADMIVTGTIAERs-- 230 Thermoplasma acido...
AAM07319  158 YALAGKYlg---mHYTYLEaGSGAdapIPPEMIGAVKKvlg-enKLIVGGGVrDAKTAKLCAsagADMIVTGTIVEEv-- 231 Methanosarcina ace...
NP_613927 154 YALAAKHlg---mKAVYLEaGSGApepVPPEVVRRVSGig---vFTIVGGGIrSPETARELAeagADAIVTGTAVERd-- 225 Methanopyrus kandl...
NP_930584 157 IARALEGidfnllKVFYLY-SRNSv--ISNEICSFVKFivgdntLLFVSGGIsNTEQVNNLLysgADFISIGTTFEEvnw 233 Photorhabdus lumin...
YP_448311 156 YALAAEFlg---mRVIYLEaGSGAdshIPVDFIMKVKKlt--nlMVIVGGGIkTAQDALEVKeagADIIITGTVVEEt-- 228 Methanosphaera sta...

Feature 1              
1VIZ_B    217 fDRALKTVA 225 Bacillus subtilis
2F6X_B    226 iDAFLETLP 234 Archaeoglobus fulgidus
AAB85058  232 dNVEDKIRE 240 Methanothermobacter thermautotrophicus str. Delta H
NP_143028 236 kSLEEARKR 244 Pyrococcus horikoshii OT3
NP_248246 232 pKAVEMMYD 240 Methanocaldococcus jannaschii DSM 2661
NP_394455 231 vNVYEALHP 239 Thermoplasma acidophilum DSM 1728
AAM07319  232 kDVAAKVAE 240 Methanosarcina acetivorans C2A
NP_613927 226 pDLAAEIVE 234 Methanopyrus kandleri AV19
NP_930584 234 nNNAINILN 242 Photorhabdus luminescens subsp. laumondii TTO1
YP_448311 229 dDTYKKIKE 237 Methanosphaera stadtmanae DSM 3091

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