1LL2,1LL0


Conserved Protein Domain Family
GT8_Glycogenin

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cd02537: GT8_Glycogenin 
Click on image for an interactive view with Cn3D
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen.
Glycogenin initiates the biosynthesis of glycogen by incorporating glucose residues through a self-glucosylation reaction at a Tyr residue, and then acts as substrate for chain elongation by glycogen synthase and branching enzyme. It contains a conserved DxD motif and an N-terminal beta-alpha-beta Rossmann-like fold that are common to the nucleotide-binding domains of most glycosyltransferases. The DxD motif is essential for coordination of the catalytic divalent cation, most commonly Mn2+. Glycogenin can be classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. It is placed in glycosyltransferase family 8 which includes lipopolysaccharide glucose and galactose transferases and galactinol synthases.
Statistics
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PSSM-Id: 133018
View PSSM: cd02537
Aligned: 38 rows
Threshold Bit Score: 195.173
Threshold Setting Gi: 134115829
Created: 28-Oct-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site
Evidence:
  • Structure:1ll2_a; Rabbit Muscle Glycogenin Complexed With Udp-Glucose And Manganese, defined by distance of 3.5A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1LL2_A        4 QAFVTLTTNd--AYAKGALVLGSSLKQHRt-----SRRLAVLTTpq-vSDTMRKALEIvf----dEVITVDILdsgdsah 71  rabbit
ABK22947     24 RAYVTFLAGc-gDYVKGVVGLAKGLRNVKs-----AYPLVVAVLad-vPEDHRLQLRRqg----cIVRQIQPIdppdnev 92  Sitka spruce
BAB10052     22 RAYVTFLAGn-kDYWMLVVGLAKGLRKVKs-----AYPLVVATLpd-vPEEHRQILVDqg----cIIRDIEPVyppentt 90  thale cress
EAA28479      9 MIWSTLVTKr--AYLGGALVLNHSLKKVGs-----RYQLKIMVTr---EAQADKEFMAvfaaagiPTIVIETIeparq-- 76  Neurospora crass...
XP_759926    25 CAWATLLTSe--HLLPGVVVFAHSLLVQHk----sRFPLVIMATst-lSARARTMLTNmlassriIVRDISPIyptstat 97  Ustilago maydis 521
XP_501001    12 RVWTTLITNt--KYLDGLLTLDYSLKRVGs-----QYRLIALYTds-fEKEGHDALAErg----iPSKHVEYLipakskd 79  Yarrowia lipolyt...
XP_637479    90 NVYVTFADNa--EYLKGIVALRMSMINTKc-----NYGLIVFVTkq-vEQQDREPLQLld----cDVREIEMVdipkevs 157 Dictyostelium di...
EAN84110    103 IAYLTFISNe--KFVDGALVLGTSLRKTSvflqhgVADLVITITsncvSAVSRKRLLEegg--ytHVFEVPSLagriha- 177 Trypanosoma cruzi
EAL18984     62 EAYVTFLSNedpYYFQSARLLVYALQHDPlta-dpSRPVIVLTTpg-vPASYSRKLEAeg----aIVIEKPFItslpmv- 134 Cryptococcus neo...
ZP_00379865 266 CAYVTMCDSq--DYLWGVRALANSLGRVS------DVPLILMVPp--gFDCGDITFEMgn----vRLYEVNSIrsphqpk 331 Brevibacterium l...
Feature 1                 ##  #             # ###                                #              
1LL2_A       72 ltlmkrpelGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFer------------eELSAAPDpgw----------- 128 rabbit
ABK22947     93 --qfsmpyyVLNYSKLRIWEFEEYSKMVYLDADIQVFDNIDHLFdlr----------dgYFYAVMDcfcektwshtpqyk 160 Sitka spruce
BAB10052     91 --gysmayyVINYSKLRIWEFVEYEKMIYLDGDIQVFKNIDHLFdtp----------rgYLYAVKDcfcevswsktpqyk 158 thale cress
EAA28479     77 -----gkvnKAFWQKLAPWAMTEYERIVLLDSDQVILQNIDHLMtlhl--------pegHIACSHActcnprklahypkd 143 Neurospora crass...
XP_759926    98 --glaytrfNEVWTKLRAFELTEYDRVGLVDSDMLVLENMDELFseehvfglgrnegeeWIGASWActcnpnriatypad 175 Ustilago maydis 521
XP_501001    80 --ysqdvrfYDCWSKLQPFSLFEYDKVVQLDSDMVVVQNMDELFdlpvges-ngngstwAFAASHActcnpynkphypkd 156 Yarrowia lipolyt...
XP_637479   158 ---vqidrwRPAFTKFRAWQLVEYERVIWLDSDMLLLKSLDHLFdlvdi------gnpkLLYAAIDadanscv------- 221 Dictyostelium di...
EAN84110    178 ----ksgifRDTFDKIYMFNLTMYEKIVFLDADMIAIRSMDKLFskpki------wgpdYVAAVGGn------------- 234 Trypanosoma cruzi
EAL18984    135 ---qtnprwKDVYTKLWIFNMTSYDRLVYYDADHLVLRPVDSIWeaens------wpesGLAALGSgdggy--------- 196 Cryptococcus neo...
ZP_00379865 332 ---qhqsrfSNTYTKLEAFGLTFLDRVAFIDADTVVLQSTDELFef------------eGFAAAPDfglr---------- 386 Brevibacterium l...
Feature 1                                           ###                                   ##    
1LL2_A      129 --------------------------------pdCFNSGVFVYQPSvETYNQLLHVASEQgs--------fdGGDQGLLN 168 rabbit
ABK22947    161 igycq-----------qcpekvswpielgqrpslYFNAGMFVFEPSqLTFDCLLETLMATvp--------tpFAEQDFLN 221 Sitka spruce
BAB10052    159 igycq----------qspekvtwpveslgapppvYFNAGMLVFGPNlVTYEDLLRVVQITtp--------tyFAEQDFLN 220 thale cress
EAA28479    144 wvpqncpf----tsadqhtgspapitpssprthhLLNSGTVVLTPSkPQFDALLDAINTHpdvp-----hmvFPDQDILA 214 Neurospora crass...
XP_759926   176 wtpsncgftrqslpeaasissvvqpsestarparLINSGLVMLTPSsSTMSEMIQRINTDaqia-----hyrFPDQDFLA 250 Ustilago maydis 521
XP_501001   157 wirencaf----tnisksddlknplfqscnlglgICNGGLQVVKPDpELYDKIIDAVSAPatg------eydFADQSLLS 226 Yarrowia lipolyt...
XP_637479   222 ---------------------------fnsdrlkLINSGIMLLSPSiDVYNLLIDGMVVVsklp----nqstVNDQDVIN 270 Dictyostelium di...
EAN84110    235 ---------------------------------dYFQTGMMIIIPTqEMFNCIYDRLIRGtppngfqftgssARDGVLLR 281 Trypanosoma cruzi
EAL18984    197 -----------------------------vedsdYFLAGFFLAIPKeEIMEGLLAERGYDp----------vFPEQNLMN 237 Cryptococcus neo...
ZP_00379865 387 ------------------------------leshRFNSGVFVCSPSsELYMSIIDAIPDTps--------ydGGDQGFLN 428 Brevibacterium l...
Feature 1                               ##                   # ##      #                        
1LL2_A      169 TFFNswattdirKHLPFI--YNLSSISiysylpafkafganAKVVHFLGq----TKPWNYtydtktksvrseghdptmth 242 rabbit
ABK22947    222 MFFEki-----yKPIPLA--YNLVLAMmwrhpq--nvdldtVKVVHYCAa---gSKPWRFsgkeenme--------redi 281 Sitka spruce
BAB10052    221 IYFRdi-----yKPIPST--YNLVMAMlwrhpe--hidldqISVVHYCAn---gSKPWKFdeaeehmd--------redi 280 thale cress
EAA28479    215 IVYRgk-----wKPLPYV--YNALKPMrdchas--lwrdedVKILHYIL-----NKPWESrdfden-----------dkv 269 Neurospora crass...
XP_759926   251 DFFTrsngnrhiRYLPYI--YNALKKLrsvhtn--iwsdthAKNVHYIL-----DKPWTLgrpatksnv-----dakdpd 316 Ustilago maydis 521
XP_501001   227 DVFKdr-----wIGLSYR--YNALKTLrvfhke--lwddsvIKNIHYIIt----PKPWEVeedeye------------dt 281 Yarrowia lipolyt...
XP_637479   271 TTLPh------wRSLSYPe-YGVQITHcectseprlwnftnTYFLHFTAglkelPKPWSLlkksqneakdi-fkqmptci 342 Dictyostelium di...
EAN84110    282 DVFQtr-----fHAINPKysRNLNPRHrldmkl---pgkqsIVAVHLRGi----IKPWHDrrlpnphte-----lgkkef 344 Trypanosoma cruzi
EAL18984    238 KYFSrdgl-rpwAPLNPI--HERISPKye----------hvEQGAHTIH-----EKCWQGwverrlae--------lfye 291 Cryptococcus neo...
ZP_00379865 429 VIMDe------iTWLPHQ--FNTLRRAlgrypd--virgdeARIVHFVG-----PKPWSLngepewsdl-----dglwfa 488 Brevibacterium l...
Feature 1                     
1LL2_A      243 pqfLNVWWDIFTTS 256 rabbit
ABK22947    282 ktlVQKWWDIYNDP 295 Sitka spruce
BAB10052    281 kmlVKKWWEIYEDS 294 thale cress
EAA28479    270 estHRLWWGVWEEV 283 Neurospora crassa OR74A
XP_759926   317 aeiHAWWWNVFDQL 330 Ustilago maydis 521
XP_501001   282 tgtFKWWWDINKER 295 Yarrowia lipolytica CLIB122
XP_637479   343 eqiYLNWINTYKEA 356 Dictyostelium discoideum AX4
EAN84110    345 gftYLHWWTLYEEE 358 Trypanosoma cruzi
EAL18984    292 rlgRMEGYWLAKES 305 Cryptococcus neoformans var. neoformans B-3501A
ZP_00379865 489 qlsEREKIQFIIEL 502 Brevibacterium linens BL2

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