1VH3,1VH1,1H6J


Conserved Protein Domain Family
CMP-KDO-Synthetase

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cd02517: CMP-KDO-Synthetase 
Click on image for an interactive view with Cn3D
CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide.
CMP-KDO Synthetase: 3-Deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) catalyzes the conversion of CTP and 3-deoxy-D-manno-octulosonate into CMP-3-deoxy-D-manno-octulosonate (CMP-KDO) and pyrophosphate. KDO is an essential component of the lipopolysaccharide found in the outer surface of gram-negative eubacteria. It is also a constituent of the capsular polysaccharides of some gram-negative eubacteria. Its presence in the cell wall polysaccharides of green algae and plant were also discovered. However, they have not been found in yeast and animals. The absence of the enzyme in mammalian cells makes it an attractive target molecule for drug design.
Statistics
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PSSM-Id: 133010
View PSSM: cd02517
Aligned: 104 rows
Threshold Bit Score: 245.076
Threshold Setting Gi: 145219488
Created: 28-Oct-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ligand bindingoligomer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ligand binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ###                                      #                          #     
1VH3_A         2 SFTVIIPARFASSRLPGKPLADIKGKPXIQHVFEKALqs-gASRVIIATDNeNVADVAKSfGAEVCXTSvnhnSGTERLA 80  Haemophilus inf...
AAP35723       6 KYAVVIPARHASTRLPGKPLLDLCGVPMIVRTYRQCIqavdAEHVLVATDDeRIRAVCEGeGIRTLMTSsrclTGTDRVA 85  Pseudomonas aer...
YP_563668      2 ECAVVIPARYQSSRFPGKPLVNILGKPMIQHVWERCSaavgAENVYVATDNdKIYEVCNAfGAKVIMTSseclTGTDRLA 81  Shewanella deni...
YP_866024      9 RVLAVIPARWASSRFPGKPLVEIAGKIMIQRVWEQASraacVDAVVIATDDaRIEQACHArGMPVVMTRddhpTGTDRLA 88  Magnetococcus s...
ZP_01437376    2 ATIAIIPCRYGASRFPGKPLSDIHGKPMLWHVYHQATkapsIDRVIIATDDdRIYQKCEIlGLEVMMTRgdhvSGTDRVA 81  Fulvimarina pel...
ZP_01885924    2 SYIVVIPARYKSTRFPGKPLTDINGKSMLLRTYEQCMkavdPSLVYVATEDqRIVDHCESfGIQVLLTSddclTGTDRIA 81  Pedobacter sp. ...
EAT03106       7 KTIALIPARLQSTRLPRKALADICGLPMIVHVYRRCMlakhVDEVYVATDNeEICETVESlGGRVIMTStaheTGTDRIA 86  delta proteobac...
ZP_01052746    2 KIVGVIPARYQSSRFPGKPLVDLNGVPMIIRVANIVEkclgKDNTYVATDDnRIKEVVEFhGFKAIMTSsdclTGTDRVY 81  Tenacibaculum s...
CAE06940       2 KVCVVIPARYSSSRFPGKPLVNLLYKPMIIWVADIAAravgIEHVYVATDDtRIADAVTSyGYKFIETSphalTGTDRVA 81  Synechococcus s...
YP_001130197  11 TVWGLIPARLGSSRLNGKALRLLHGLPMVIHVAKRAKlakhLDRVLICTDSeKILQASIKyGIEACVTSsdckNGTERII 90  Prosthecochlori...
Feature 1                         # #                                                            
1VH3_A        81 EVVEKLaipdneIIVNIQGDEPLIPPVIVRQVADNLakf---nvNXASLAVKIHdaeelfnPNAVKVLTDkdGYVLYFSR 157 Haemophilus inf...
AAP35723      86 EVAGQVsa---eIFINVQGDEPLFNPDDLRKLIDAAqas---peAIINGYCGIAdettfrnPSVPKVVFRpdGRLLYMSR 159 Pseudomonas aer...
YP_563668     82 EANLQLdc---dFIINVQGDEPLIEPDDIRTVIAKYkeq---pnTVVNAMCAIYsedefrsFTVPKVVVSktGNLLYMSR 155 Shewanella deni...
YP_866024     89 EVAQQQea---dIYLNVQGDEPLINPDTIDAVAQCLldalprgiGLATAYMDGAsqaqkasPSTVHLVPSmdGCVITFSR 165 Magnetococcus s...
ZP_01437376   82 ECASRLdg---eVFVNVQGDEPMIEPEAIERVAKAIlestdeniVASNGFNEMCdpsdvidTNVVKVVMRqdGRALAYSR 158 Fulvimarina pel...
ZP_01885924   82 EVADLVka---dYYINVQGDEPLFNPEDISKVISLLdty---sgDILNGYCAIDndhqyrsVSVPKVVFRpdGRLLYMSR 155 Pedobacter sp. ...
EAT03106      87 EAARKLdt---eIVVNVQGDEVLVNPEYIDRVVEALyfd--pslDVAILVNPFYkr---dsPSDIKAVLNeqNDVMYLSR 158 delta proteobac...
ZP_01052746   82 DFSKQIka---dIYVNVQGDEPLLNHKDIQKIINTKkin---mkSVINGMCSLTsdenphnVNIPKVVTNkfNDLLYMSR 155 Tenacibaculum s...
CAE06940      82 EASKQIdy---dIYINVQGDEPTIDHLEILKCIQLKken---fdCVVNGYCTIStnsnpssKNIPKVVKTekNRLVYMSR 155 Synechococcus s...
YP_001130197  91 HAKRLMqipdndIIIDIQGDEPLVSPDTIDDVVNTStnv--lgeFDIVLPHQLDale--nkKNVVKVVSSg-NRVIYLTR 165 Prosthecochlori...
Feature 1                                                                                        
1VH3_A       158 SVIPYdrdqfxnlqdvqkvqlsdAYLRHIGIYAYRAGFIKQYVQWAP-TQLENLEKLEQLRVLYNGERIHVELAKEvpAV 236 Haemophilus inf...
AAP35723     160 AAIPTtkqg-----------efsRAWRQVCAYAFPREALRAFAARPTkTSLEEVEDIEILRFLELGWEVKMIEMSDq-SI 227 Pseudomonas aer...
YP_563668    156 SPIPVtknn-----------eytFGYKQVCIYAFSKEHLVFFASHKEkTKIEQVEDIEILRFIENDIPVQMIEVPSs-SI 223 Shewanella deni...
YP_866024    166 LPVPLdfq------------asfDHKVHVGLYAFTRDALMEFVALER-GPVERAESIEPLRFIERGKRIACVKVPGg-SV 231 Magnetococcus s...
ZP_01437376  159 MPIPFpkg------------gkvQYFRQLGLYAFRKHGLERFVASKP-GPLEMAEGVEMFRFLEHGYDVNMVQVPNdrGI 225 Fulvimarina pel...
ZP_01885924  156 SAIPGnkav-----------afvKAWRQVCIYAFPFEALKAFAASNGkTPLEAEEDIEILRFLELGYEVRMLELSSe-SV 223 Pedobacter sp. ...
EAT03106     159 TDIPSdars-----------snpQLLKAYHIVPFRKEFLLRYAAWEK-GVLEQIEFNEYLRILEKGFRIRAVRVESd-AV 225 delta proteobac...
ZP_01052746  156 LAVPGiknfk--------nnvqpDYKKQVCIYAFSQEELQAYGSQKEkSVFEGFEDIEILRFFDLNIPIKMVETSGs-SL 226 Tenacibaculum s...
CAE06940     156 SLVPGfkdln---------impkEYLKQVCIYGFSFEELQLFSNYGRkSLLEQSEDIEILRFLDLGKQVLMYQCAKe-SL 225 Synechococcus s...
YP_001130197 166 SDAPYpfv------------edrLLKKHLSVIGFTGASLEKFACIEQ-GELEKTEGVELLRALEGGMSIFTFPQQVh-SF 231 Prosthecochlori...
Feature 1                      
1VH3_A       237 GVDtAEDLEKVRAI 250 Haemophilus influenzae
AAP35723     228 SVDnLEDVERVLDA 241 Pseudomonas aeruginosa
YP_563668    224 AVDtPGDVQRVIMR 237 Shewanella denitrificans OS217
YP_866024    232 GVDhPEDVTRVEAL 245 Magnetococcus sp. MC-1
ZP_01437376  226 PVDtPSDLERVRAM 239 Fulvimarina pelagi HTCC2506
ZP_01885924  224 AVDnPEDLGEVLAR 237 Pedobacter sp. BAL39
EAT03106     226 SVDtSEDLEYVRNK 239 delta proteobacterium MLMS-1
ZP_01052746  227 AVDiLEDVAKVEAV 240 Tenacibaculum sp. MED152
CAE06940     226 AVDvPSDIQIVEDY 239 Synechococcus sp. WH 8102
YP_001130197 232 SVDiQEDFERAERV 245 Prosthecochloris vibrioformis DSM 265

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