Conserved Protein Domain Family
TPP_IolD

?
cd02003: TPP_IolD 
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.
Statistics
?
PSSM-Id: 238961
Aligned: 15 rows
Threshold Bit Score: 315.399
Created: 4-Nov-2004
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
TPP-binding
Feature 1:TPP-binding site
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #                        ####  
AAQ87375  397 QGTIVRIVNESTRAGDVVIAAAGTPPGEIHKAWDNSNGSKAFLEFGFSTMGHEIPAAIGARLANRsDEEIFVIIGDGTYL 476 Rhizobium sp. NGR234
P42415    362 QTTALLTINETIPEDSVIICSAGSLPGDLQRLWHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHP-DREVYSIVGDGSFL 440 Bacillus subtilis
NP_992504 441 QTRVLGLINQHIEDDAIVVGAAGSLPGDLQRLWQVKTADTYHLEYGYSCMGYEIAAAIGAKIAMP-HQPVYAMVGDGSYM 519 Yersinia pestis bi...
YP_102640 426 VIGAVQRSAPDSAARDIAVCAAGTLPAELHKLWRAAAPGGYHVEYGYSCMGYEIAGGLGAKLAKP-EREVIVMVGDGSYL 504 Burkholderia malle...
YP_115663 430 QSRALYLIRKYIDPKASITAAAGSLPGDLQRLWETDEFGSYNVEYGYSCMGHEIQAAIGSSIALG-FRPTYALVGDGSFL 508 Mycoplasma hyopneu...
YP_132135 400 YAEVIGKLNTQMEKGDTVLTAAGGLPAELSMNWQNYQIGKFDIDFGFSCMGYEIAGGWGAKIANP-DNDVVVLVGDGSYL 478 Photobacterium pro...
YP_132149 397 DAEVIGAVNRAADEKDIVVCAAGGLPGELHKLWRTKYDKGYHLEYGFSCMGYEIAGGLGVKMAKP-DSDVIVMIGDGSYL 475 Photobacterium pro...
NP_733719 399 QTQVLGALDAVVGDEDVVINAAGSLPGDLHKLWRARSPRQYHLEYGYSCMGYEIPAALGVQQAAP-GTPVWALVGDGTYL 477 Streptomyces coeli...
BAB79795  415 QTAALGVIRETIDDDAIVVGAAGSLPGDLQRMWETDARDSYHMEYGYSCMGYEIAATLGAKLAEP-EREVYSMVGDGSYL 493 Clostridium perfri...
BAB51513  419 DAQVIGGVQRAMGSGVTLLHAAGGLPGELHKLWQAGTPGSYHAEYGFSTMGYEIAGGLGTKMAKP-GEEVVVMIGDGSYL 497 Mesorhizobium loti...
Feature 1                           # #                                                       
AAQ87375  477 MGPTEIVTAVQENAKITVVVIENYGYQCIRDLQEnSTGIDNLGNEFRArdndvlrpngsyLEVDYAANARSMGAAVLSAs 556 Rhizobium sp. NGR234
P42415    441 MLHSELITAIQYNKKINVLLFDNSGFGCINNLQM-DHGSGSYYCEFRTddn-------qiLNVDYAKVAEGYGAKTYRAn 512 Bacillus subtilis
NP_992504 520 MLHSELHTAVQEGLKITVLLFDNAGFGCINNLQM-GHGMGSFCTESRHrnhesgqlngplICVDFAQNAESYGCRAWRVh 598 Yersinia pestis bi...
YP_102640 505 MMNSEIATSVMLGAKLIVVVLDNRGYGCINRLQQ-ACGGAPFNNLFDDcvqg----plgaPRIDFAAHARALGARAEHVa 579 Burkholderia malle...
YP_115663 509 MLHSEMLTAIQEQVPVVIILFDNSGFGCINNLQV-GSNIRSFETEFYTrsqknlneygslVITEFATIAKGYGFRSVFAr 587 Mycoplasma hyopneu...
YP_132135 479 IQNSDIYSSVLTGQKMILVVCDNGGFAVINKLQN-NTGNESFNNLLEDcrrp----dgelARVDFAKHAESQGAISEKLt 553 Photobacterium pro...
YP_132149 476 MLNSEIATSVMLDQKLILVVLDNRGYGCISRLQH-ACGGAGFNNLLKDckti----dggaPKTDFAAHAKALGANSEKVg 550 Photobacterium pro...
NP_733719 478 MNPTEIVTAVQENLPVKLVLVQNHGYASIGGLSE-SVGAERFGTDYRHrvadgs-ftgapLPVDLAANAASLGMDVLRAk 555 Streptomyces coeli...
BAB79795  494 MLHSEMVTAMQEQKKINILLFDNCGFGCINNLQM-SNGIGSLATEFRYrdengk-legglIPIDFAKVASGYGLKTYSVk 571 Clostridium perfri...
BAB51513  498 MLNSEIATSVMLGLKLIIVLLDNRGYGCINRLQM-ATGGANFNNLLKDsrh------eilPDIDFAAHAASMGAIAEKVp 570 Mesorhizobium loti...
Feature 1                                                    
AAQ87375  557 deeQFKDALAKARDVRGPTVIVVKAEKRGRSIGSGVWWDVGASEVTN 603 Rhizobium sp. NGR234
P42415    513 tveELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSE 559 Bacillus subtilis
NP_992504 599 depSLLAALAASRDHPGPVLLDIKVLPKSMTHDYASWWRTGDAQIAR 645 Yersinia pestis biovar Medievalis str. 91001
YP_102640 580 diaALEAAMARARASDRTYVICIDTDPARTTPDGGWWWEVAVPEVSP 626 Burkholderia mallei ATCC 23344
YP_115663 588 seqEFIMALKQSKRTKKPMLIEIKVYPKSMTPGFESFWQTGLSLVSK 634 Mycoplasma hyopneumoniae 232
YP_132135 554 sidQFDAAFIRAKEADRTYVIVVDIDPVSPAAWSKCDCWWEVGLPEV 600 Photobacterium profundum SS9
YP_132149 551 citELEQALIRAKQSDKTYVITLDTDPLSTTESGGSWWEVAVPEVSE 597 Photobacterium profundum SS9
NP_733719 556 tvrELREALSTARAASRPTCVYVETAPPSAALPAQAWWDVPVAEVSA 602 Streptomyces coelicolor A3(2)
BAB79795  572 tlaQLKEALEDAKKQKVSTLIDIKVLPKTMTDGYDAWWHVGIAGESE 618 Clostridium perfringens str. 13
BAB51513  571 siaGLENALQKAKTNDRTTVLVIDTDPLVSTDAGGHWWDVAVPEVSA 617 Mesorhizobium loti MAFF303099

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap